RNA secondary structure formation: a solvable model of heteropolymer folding

The statistical mechanics of heteropolymer structure formation is studied in the context of RNA secondary structures. A designed RNA sequence biased energetically towards a particular native structure (a hairpin) is used to study the transition between the native and molten phase of the RNA as a function of temperature. The transition is driven by a competition between the energy gained from the polymer's overlap with the native structure and the entropic gain of forming random contacts. A simplified Go-like model is proposed and solved exactly. The predicted critical behavior is verified via exact numerical enumeration of a large ensemble of similarly designed sequences.Comment: 4 pages including 2 figure

Folding in two-dimenensional off-lattice models of proteins

Model off-lattice sequences in two dimensions are constructed so that their native states are close to an on-lattice target. The Hamiltonian involves the Lennard-Jones and harmonic interactions. The native states of these sequences are determined with a high degree of certainty through Monte Carlo processes. The sequences are characterized thermodynamically and kinetically. It is shown that the rank-ordering-based scheme of the assignment of contact energies typically fails in off-lattice models even though it generates high stability of on-lattice sequences. Similar to the on-lattice case, Go-like modeling, in which the interaction potentials are restricted to the native contacts in a target shape, gives rise to good folding properties. Involving other contacts deteriorates these properties.Comment: REVTeX, 9 pages, 8 EPS figure

On the stability of renormalizable expansions in three-dimensional gravity

Preliminary investigations are made for the stability of the $1/N$ expansion in three-dimensional gravity coupled to various matter fields, which are power-counting renormalizable. For unitary matters, a tachyonic pole appears in the spin-2 part of the leading graviton propagator, which implies the unstable flat space-time, unless the higher-derivative terms are introduced. As another possibility to avoid this spin-2 tachyon, we propose Einstein gravity coupled to non-unitary matters. It turns out that a tachyon appears in the spin-0 or -1 part for any linear gauges in this case, but it can be removed if non-minimally coupled scalars are included. We suggest an interesting model which may be stable and possess an ultraviolet fixed point.Comment: 32 pages. (A further discussion to avoid tachyons is included. To be Published in Physical Review D.

Evidence for CP Violation in B0 -> D+D- Decays

We report measurements of the branching fraction and CP violation parameters in B0 -> D+D- decays. The results are based on a data sample that contains 535 x 10^6 BBbar pairs collected at the Upsilon(4S) resonance, with the Belle detector at the KEKB asymmetric-energy e+e- collider. We obtain [1.97 +- 0.20 (stat) +- 0.20 (syst)] x 10^(-4) for the branching fraction of B0 -> D+D-. The measured values of the CP violation parameters are: S = -1.13 +- 0.37 +- 0.09, A = 0.91 +- 0.23 +- 0.06, where the first error is statistical and the second is systematic. We find evidence of CP violation in B0 -> D+D- at the 4.1 sigma confidence level. While the value of S is consistent with expectations from other measurements, the value of the parameter A favors large direct CP violation at the 3.2 sigma confidence level, in contradiction to Standard Model expectations.Comment: 12 pages, 3 figures, submitted to PR

Search for the h_c meson in B^+- ->h_c K^+-

We report a search for the $h_c$ meson via the decay chain $B^{\pm}\to h_c K^{\pm}$, \etac \gamma with $\eta_c \to K_S^0 K^{\pm} \pi^{\mp}$ and $p\bar{p}$. No significant signals are observed. We obtain upper limits on the branching fractions for $B^{\pm} \to \eta_c\gamma K^{\pm}$ in bins of the $\eta_c\gamma$ invariant mass. The results are based on an analysis of 253 fb$^{-1}$ of data collected by the Belle detector at the KEKB $e^+e^-$ collider.Comment: 12 pages, 6 figures, submitted to Phys. Rev.

Evidence of the Purely Leptonic Decay B- --> tau- nu_tau-bar

We present the first evidence of the decay B- --> tau- nu_tau-bar using 414 fb^-1 of data collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. Events are tagged by fully reconstructing one of the B mesons in hadronic modes. We detect the signal with a significance of 3.5 standard deviations including systematics, and measure the branching fraction to be Br(B- --> tau- nu_tau-bar) = (1.79 +0.56-0.49(stat) +0.46-0.51(syst))*10^-4. This implies that f_B = 0.229 +0.036-0.031(stat) +0.034-0.037(syst) GeV and is the first direct measurement of this quantity.Comment: 6 pages, 3 figures, to appear in Physical Review Letter

Experiences of refugees and asylum seekers in general practice: a qualitative study

Background: There has been much debate regarding the refugee health situation in the UK. However most of the existing literature fails to take account of the opinions of refugees themselves. This study was established to determine the views of asylum seekers and refugees on their overall experiences in primary care and to suggest improvements to their care. Methods: Qualitative study of adult asylum seekers and refugees who had entered the UK in the last 10 years. The study was set in Barnet Refugee Walk in Service, London. 11 Semi structured interviews were conducted and analysed using framework analysis. Results: Access to GPs may be more difficult for failed asylum seekers and those without support from refugee agencies or family. There may be concerns amongst some in the refugee community regarding the access to and confidentiality of professional interpreters. Most participants stated their preference for GPs who offered advice rather than prescriptions. The stigma associated with refugee status in the UK may have led to some refugees altering their help seeking behaviour. Conclusion: The problem of poor access for those with inadequate support may be improved by better education and support for GPs in how to provide for refugees. Primary Care Trusts could also supply information to newly arrived refugees on how to access services. GPs should be aware that, in some situations, professional interpreters may not always be desired and that instead, it may be advisable to reach a consensus as to who should be used as an interpreter. A better doctor-patient experience resulting from improvements in access and communication may help to reduce the stigma associated with refugee status and lead to more appropriate help seeking behaviour. Given the small nature of our investigation, larger studies need to be conducted to confirm and to quantify these results

Fusion Operators in the Generalized τ(2)\tau^{(2)}-model and Root-of-unity Symmetry of the XXZ Spin Chain of Higher Spin

We construct the fusion operators in the generalized $\tau^{(2)}$-model using the fused $L$-operators, and verify the fusion relations with the truncation identity. The algebraic Bethe ansatz discussion is conducted on two special classes of $\tau^{(2)}$ which include the superintegrable chiral Potts model. We then perform the parallel discussion on the XXZ spin chain at roots of unity, and demonstrate that the $sl_2$-loop-algebra symmetry exists for the root-of-unity XXZ spin chain with a higher spin, where the evaluation parameters for the symmetry algebra are identified by the explicit Fabricius-McCoy current for the Bethe states. Parallels are also drawn to the comparison with the superintegrable chiral Potts model.Comment: Latex 33 Pages; Typos and errors corrected, New improved version by adding explanations for better presentation. Terminology in the content and the title refined. References added and updated-Journal versio

Study of time-dependent CP violation in B0 -> J/Psi pi0 decays

We report a measurement of CP asymmetry parameters in the decay B0(B0bar) -> J/Psi pi0, which is governed by the b->c cbar d transition. The analysis is based on a 140/fb data sample accumulated at the Upsilon(4S) resonance by the belle detector at the KEKB asymmetric-energy e+e- collider. We fully reconstruct one neutral B meson in the J/Psi pi0 final state. The accompanying B meson flavor is identified by its decay products. From the distribution of proper time intervals between the two B decays, we obtain the following CP-violating parameters: S_{J/Psi pi0}=-0.72+-0.42+-0.09 and A_{J/Psi pi0}=-0.01 +-0.29+-0.03.Comment: 5 pages, 2 figures, submitted to PR