A Multi-Membership Catalogue for 1876 Open Clusters using UCAC4 data

The main objective of this work is to determine the cluster members of 1876 open clusters, using positions and proper motions of the astrometric catalogue UCAC4. For this purpose we apply three different methods, all them based on a Bayesian approach, but with different formulations: a purely parametric method, another completely non-parametric algorithm, and a third, recently developed by Sampedro & Alfaro, using both formulations at different steps of the whole process. The first and second statistical moments of the members phase-space subspace, obtained after applying the three methods, are compared for every cluster. Although, on average, the three methods yield similar results, specific differences between them, as well as for some particular clusters, are also present. The comparison with other published catalogues shows good agreement. We have also estimated for the first time the mean proper motion for a sample of 18 clusters. The results are organized in a single catalogue formed by two main files, one with the most relevant information for each cluster, partially including that in UCAC4, and the other showing the individual membership probabilities for each star in the cluster area. The final catalogue, with an interface design that enables an easy interaction with the user, is available in electronic format at SSG-IAA (http://ssg.iaa.es/en/content/sampedro-cluster-catalog) website.Comment: Accepted for publication in MNRAS. 9 pages, 3 figures, 6 table

Environmental enrichment results in both brain connectivity efficiency and selective improvement in different behavioral tasks

Exposure to environmental enrichment (EE) has been a useful model for studying the effects of experience on brain plasticity, but to date, few is known about the impact of this condition on the brain functional networks that probably underlies the multiple behavioral improvements. Hence, we assessed the effect of an EE protocol in adult Wistar rats on the performance in several behavioral tasks testing different domains (Open field (OP): locomotor activity; Elevated-zero maze (EZM): anxiety-related behaviors; 5-choice serial reaction time task (5-CSRTT): attentional processes; 4-arm radial water maze (4-RAWM): spatial memory) in order to check its effectiveness in a wide range of functions. After this, we analyzed the functional brain connectivity underlying each experimental condition through cytochrome C oxidase (COx) histochemistry. Our EE protocol reduced both locomotor activity in the OP and anxiety-related behaviors in the EZM. On the other hand, enriched rats showed more accuracy in the 4-RAWM, whereas 5-CSRTT performance was not significantly ameliorated by EE condition. In relation to COx functional connectivity, we found that EE reduced the number of strong positive correlations both in basal and training conditions, suggesting a modulating effect on specific brain connections. Our results suggest that EE seems to have a selective effect on specific brain regions, such as prefrontal cortex and hippocampus, leading to a more efficient brain connectivity.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. PPIT.UMA.B1.2017/3

Device for data-acquisition from transient signals: kinetic considerations

This paper reports on the evaluation and testing of a home-made device. Data-acquisition, treatment of transient signals and the hardware and software involved are discussed. Some practical aspects are developed in order to power the autonomy of procedures using the device. Kinetic and multi-signal calculations are considered in order to cover the actual tendencies in continuous-flow analysis. Somepractical advantages versus the use of classical chart recorders or commercial computerized-instrument devices are pointed out

The State-of-the-Art of Phase II/III Clinical Trials for Targeted Pancreatic Cancer Therapies

Pancreatic cancer is a devastating disease with very poor prognosis. Currently, surgery followed by adjuvant chemotherapy represents the only curative option which, unfortunately, is only available for a small group of patients. The majority of pancreatic cancer cases are diagnosed at advanced or metastatic stage when surgical resection is not possible and treatment options are limited. Thus, novel and more effective therapeutic strategies are urgently needed. Molecular profiling together with targeted therapies against key hallmarks of pancreatic cancer appear as a promising approach that could overcome the limitations of conventional chemo- and radio-therapy. In this review, we focus on the latest personalised and multimodal targeted therapies currently undergoing phase II or III clinical trials. We discuss the most promising findings of agents targeting surface receptors, angiogenesis, DNA damage and cell cycle arrest, key signalling pathways, immunotherapies, and the tumour microenvironment

Physical versus economic depletion of a nonrenewable natural resource

The present paper explores the relationship between physical and economic depletion of a nonrenewable natural resource using a decomposition of mining costs akin to the one used in the literature on productivity and technical change. We argue that this decomposition can provide key insights on future availability of nonrenewable natural resources. Using data on slate mining in Galicia (Northern Spain), we provide quantitative evidence of the role played by physical depletion in economic exhaustion but also of the offsetting effects of technical change. Additionally, we provide a measure of the effects on economic depletion of input prices, output, fixed inputs and production scale. Input prices and fixed input misallocation contributes far more to economic depletion than physical depletion while technical change has a remarkable negative contribution to economic depletion. Policy implications are discussed, particularly, the importance of promoting technical change. Keywords: Non-renewable natural resources, Physical depletion, Economic depletion, Mining cost, Slate mining, Technical change, Total Cost Growth decompositio

Biliary Strictures and Cholangiocarcinoma - Untangling a Diagnostic Conundrum

Cholangiocarcinoma is an uncommon and highly aggressive biliary tract malignancy with few manifestations until late disease stages. Diagnosis is currently achieved through a combination of clinical, biochemical, radiological and histological techniques. A number of reported cancer biomarkers have the potential to be incorporated into diagnostic pathways, but all lack sufficient sensitivity and specificity limiting their possible use in screening and early diagnosis. The limitations of standard serum markers such as CA19-9, CA125 and CEA have driven researchers to identify multiple novel biomarkers, yet their clinical translation has been slow with a general requirement for further validation in larger patient cohorts. We review recent advances in the diagnostic pathway for suspected CCA as well as emerging diagnostic biomarkers for early detection, with a particular focus on non-invasive approaches

Cabergoline treatment in acromegaly: pros

Cabergoline is an ergot-derived dopamine D2 receptor agonist which may be effective for the medical management of acromegaly. Its efficacy in reducing growth hormone and IGF-I levels, as well as its antiproliferative and pro-apoptotic effects on pituitary tumor cells, has been observed in several studies. Cabergoline may be used alone or as an add-on therapy to patients who are partially resistant to somatostatin analogs (SSA), or who do not achieve complete control with maximum doses of pegvisomant (PEG). Additionally, the convenience of its oral administration, allowing better compliance, and its lower economic cost, in comparison with SSA and PEG, favor cabergoline as an attractive option for acromegalic patients, who frequently require long-life medical treatment to achieve disease control. The few adverse events observed with prolonged DA therapy, mainly regarding cardiac valve disease, are not frequent at the doses generally used in acromegaly

Poly-l/dl-lactic acid films functionalized with collagen IV as carrier substrata for corneal epithelial stem cells

Limbal epithelial stem cells (LESCs) are responsible for the renewal of corneal epithelium. Cultivated limbal epithelial transplantation is the current treatment of choice for restoring the loss or dysfunction of LESCs. To perform this procedure, a substratum is necessary for in vitro culturing of limbal epithelial cells and their subsequent transplantation onto the ocular surface. In this work, we evaluated poly-L/DL-lactic acid 70:30 (PLA) films functionalized with type IV collagen (col IV) as potential in vitro carrier substrata for LESCs. We first demonstrated that PLA-col IV films were biocompatible and suitable for the proliferation of human corneal epithelial cells. Subsequently, limbal epithelial cell suspensions, isolated from human limbal rings, were cultivated using culture medium that did not contain animal components. The cells adhered significantly faster to PLA-col IV films than to tissue culture plastic (TCP). The mRNA expression levels for the LESC specific markers, K15, P63α and ABCG2 were similar or greater (significantly in the case of K15) in limbal epithelial cells cultured on PLA-col IV films than limbal epithelial cells cultured on TCP. The percentage of cells expressing the corneal (K3, K12) and the LESC (P63α, ABCG2) specific markers was similar for both substrata. These results suggest that the PLA-col IV films promoted LESC attachment and helped to maintain their undifferentiated stem cell phenotype. Consequently, these substrata offer an alternative for the transplantation of limbal cells onto the ocular surface.This work was supported by the Carlos III National Institute of Health, Spain (CIBER-BBN and Spanish Network on Cell Therapy, (TerCel RD12/0019/0036), MINECO/FEDER, EU), and the Castilla y León Regional Government, Spain (Regional Center for Regenerative Medicine and Cell Therapy, SAN673/VA/28/08 and SAN126/VA11/09)

Does ict resources improve the sport teaching processes in handball?

La motivación (M) y la capacidad de percepción-análisis (PA) del juego, variables del proceso de enseñanza-aprendizaje, fueron evaluadas tras utilizar diferentes recursos durante las explicaciones del entrenador. 71 jugadores(Sub-18) fueron divididos en dos grupos: G1 (n=35): recursos tradicionales; G2 (n=36): recursos multimedia. Se evaluó el nivel inicial (i) y final (f), tras 10 sesiones de entrenamiento. Ambas variables mejoraron significativamente en ambos grupos. Fueron mayores las mejoras del G2 en ambas variables (p<.001). Se hallaron únicamente diferencias intergrupales en la evaluación final en M y PA (p<.001), mostrando el Grupo 2 mejores resultados. Se concluye que la utilización de recursos multimedia posee un efecto positivo mayor que los recursos tradicionales sobre M y PA en jugadores de balonmano (Sub-18).Motivation (M) and game perception-analysis ability (PA), variables in the teaching-learning process, were evaluated after using different resources during the coach’s explanations. Seventy-one players (Under-18) were divided into 2 groups: G1 (n = 35) traditional resources; G2 (n = 36) multimedia resources. Initial (i) and final (f) levels of both variables were evaluated after 10 training sessions. Both variables showed a significant improvement in both groups. The improvements shown in G2 were greater in both variables (p<0.001). Intergroup differences were only found in the final evaluation in M and PA (p<0,001), where G2 obtained better results. It was concluded that using multimedia resources has a greater positive effect than traditional resources on M and PA in under-18 handball players