The Investigation of Intermediate Stage of Template Etching with Metal Droplets by Wetting Angle Analysis on (001) GaAs Surface

In this work, we study metal droplets on a semiconductor surface that are the initial stage for both droplet epitaxy and local droplet etching. The distributions of droplet geometrical parameters such as height, radius and volume help to understand the droplet formation that strongly influences subsequent nanohole etching. To investigate the etching and intermixing processes, we offer a new method of wetting angle analysis. The aspect ratio that is defined as the ratio of the height to radius was used as an estimation of wetting angle which depends on the droplet material. The investigation of the wetting angle and the estimation of indium content revealed significant materials intermixing during the deposition time. AFM measurements reveal the presence of two droplet groups that is in agreement with nanohole investigations. To explain this observation, we consider arsenic evaporation and consequent change in the initial substrate. On the basis of our analysis, we suggest the model of droplet evolution and the formation of two droplet groups

CHRONIC MYELOID LEUKEMIA: EPIDEMIOLOGY AND FIFTEENTH YEARS OF THERAPY IN THE NOVOSIBIRSK REGION

The incidence of chronic myeloid leukemia from 2004 to 2018 amounted to 0.63 per 100 000 people per year. The prevalence of chronic myeloid leukemia over the past 15 years has increased from 1.88 to 7.02 case per 100 000 people. We have analyzed the therapy outcomes of chronic myeloid leukemia of patients, received imatinib treatment for more than 12 month (165 patients). Complete hematologic response is attained in 88.5 % cases (146 patients), complete cytogenetic response (CCR) (ph+<0 %) – in 72.1 % cases (119 patients), major molecular response (MMR) – in 50.3 % cases (83 patients). The primary resistance to imatinib is observed in 21.8 % cases (36 patients), secondary – in 6.1 % cases (10 patients – 7 patients have lost the complete hematologic response and CCR and 3 patients have lost the CCR and MMR). The thirteen patients of those, who have primary or secondary resistance to imatinib have been treated with second-generation tyrosine kinase inhibitors (nilotinib, dasatinib) and in 93,3 % cases (14 patients) CCR have been obtained, 10 patients (66.7 %) have attained the CCR and 9 patients (60 %) have achieved MMR. Among all those patients treated with I and II generations tyrosine kinase inhibitors, we have carried out the overall survival (OS) analysis and obtained following results: the median of OS have not been achieved, 5-year OS rate is estimated as 90 %, 10-year OS rate – more than 77 %, calculated 15-year OS – more than 60 %

Механизмы развития, значение и современные возможности коррекции анемии при неходжкинских лимфомах

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Апоптоз и механизмы опухолевой прогрессии неходжкинских злокачественных лимфом

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TELOMERES AND TELOMERASE ACTIVITY IN CHRONIC MYELOID LEUKEMIA (REVIEW)

A review of literature data on the change in telomere length and telomerase activity at various stages of chronic myeloid leukemia (CML) has been performed. It has been shown that telomere length is reduced faster in the BCR-ABL-positive cells due to their rapid division. It has been reported that telomere length correlates with the remaining time until the disease progresses. Thus, the accelerated reduction of telomeres can be regarded as a sign of a poor prognosis of the disease. It was found that the rate of contraction of telomere length during the progression of the disease was 10–20 times higher than that observed in normal granulocytes and blast cells (tumor samples underwent at least 30–60 additional divisions from the base length of Ph-telomeres). More than 50 % of patients with CML (blast crisis) had a 50-fold increase in telomerase activity. The length of telomeres gradually increased when the cytogenetic response was achieved in the treatment of CML by imatinib or interferon-alpha. Inhibition of telomerase is a new possible therapeutic approach to the treatment of myeloproliferative and solid tumors. Various therapeutic approaches to the inhibition of telomerase have been developed

СТАТИСТИЧЕСКОЕ РАССМОТРЕНИЕ АНСАМБЛЯ КВАНТОВЫХ ТОЧЕК INAS НА ПОВЕРХНОСТИ (001)GAAS STATISTICAL APPROACH TO THE STRAIN-DRIVEN FORMATION OF InAs QUANTUM DOTS ON GaAs(001)

http://elibrary.ru/item.asp?id=18059795It is shown that the change of the growth mode from 2D to 3D in the formation of InAs quantum dots on (001) GaAs i.e. Stranski-Krastanov transition is actually a two-dimensional phase transition in the lattice-gas model. Three-parameter isotherms are used to describe the phase transition and the parameters of lateral interaction leading to the condensation of quantum dots are defined