Scaling of the electron dissipation range of solar wind turbulence

Electron scale solar wind turbulence has attracted great interest in recent years. Clear evidences have been given from the Cluster data that turbulence is not fully dissipated near the proton scale but continues cascading down to the electron scales. However, the scaling of the energy spectra as well as the nature of the plasma modes involved at those small scales are still not fully determined. Here we survey 10 years of the Cluster search-coil magnetometer (SCM) waveforms measured in the solar wind and perform a statistical study of the magnetic energy spectra in the frequency range [$1, 180$]Hz. We show that a large fraction of the spectra exhibit clear breakpoints near the electon gyroscale $\rho_e$, followed by steeper power-law like spectra. We show that the scaling below the electron breakpoint cannot be determined unambiguously due to instrumental limitations that will be discussed in detail. We compare our results to recent ones reported in other studies and discuss their implication on the physical mechanisms and the theoretical modeling of energy dissipation in the SW.Comment: 10 pages, submitte

A Hot Helium Plasma in the Galactic Center Region

Recent X-ray observations by the space mission Chandra confirmed the astonishing evidence for a diffuse, hot, thermal plasma at a temperature of 9. $10^7$ K (8 keV) found by previous surveys to extend over a few hundred parsecs in the Galactic Centre region. This plasma coexists with the usual components of the interstellar medium such as cold molecular clouds and a soft (~0.8 keV) component produced by supernova remnants, and its origin remains uncertain. First, simple calculations using a mean sound speed for a hydrogen-dominated plasma have suggested that it should not be gravitationally bound, and thus requires a huge energy source to heat it in less than the escape time. Second, an astrophysical mechanism must be found to generate such a high temperature. No known source has been identified to fulfill both requirements. Here we address the energetics problem and show that the hot component could actually be a gravitationally confined helium plasma. We illustrate the new prospects this opens by discussing the origin of this gas, and by suggesting possible heating mechanisms.Comment: 9 pages, accepted for publication in APJ

Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease

Effective treatment options for advanced colorectal cancer (CRC) are limited, survival rates are poor and this disease continues to be a leading cause of cancer-related deaths worldwide. Despite being a highly heterogeneous disease, a large subset of individuals with sporadic CRC typically harbor relatively few established ‘driver’ lesions. Here, we describe a collection of genetically engineered mouse models (GEMMs) of sporadic CRC that combine lesions frequently altered in human patients, including well-characterized tumor suppressors and activators of MAPK signaling. Primary tumors from these models were profiled, and individual GEMM tumors segregated into groups based on their genotypes. Unique allelic and genotypic expression signatures were generated from these GEMMs and applied to clinically annotated human CRC patient samples. We provide evidence that a Kras signature derived from these GEMMs is capable of distinguishing human tumors harboring KRAS mutation, and tracks with poor prognosis in two independent human patient cohorts. Furthermore, the analysis of a panel of human CRC cell lines suggests that high expression of the GEMM Kras signature correlates with sensitivity to targeted pathway inhibitors. Together, these findings implicate GEMMs as powerful preclinical tools with the capacity to recapitulate relevant human disease biology, and support the use of genetic signatures generated in these models to facilitate future drug discovery and validation efforts

Searching for TeV DM evidence from Dwarf Irregular Galaxies with the HAWC Observatory

The dynamics of dwarf irregular (dIrr) galaxies are observed to be dominated by dark matter (DM). Recently, the DM density distribution has been studied for 31 dIrrs. Their extended DM halo (Burket type profile) makes these objects good candidates for DM searches. Located in Puebla (Mexico), the High Altitude Water Cherenkov (HAWC) Observatory is an optimal instrument to perform such DM searches, because of its large sky coverage (8.4 sr per day). We analyzed a set of two years of HAWC data and we found no significant DM signal from dIrr galaxies. We present the upper limits for DM annihilation cross-section with dIrr galaxies

A unified accretion-ejection paradigm for black hole X-ray binaries. III. Spectral signatures of hybrid disk configurations

It has been suggested that the cycles of activity of X-ray Binaries (XrB) are triggered by a switch in the dominant disk torque responsible for accretion (paper I). As the disk accretion rate increases, the disk innermost regions would change from a jet-emitting disk (JED) to a standard accretion disk (SAD). While JEDs have been proven to successfully reproduce hard states (paper II), the existence of an outer cold SAD introduces an extra non local cooling term. We investigate the thermal structure and associated spectra of such a hybrid disk configuration. We use the 2T plasma code elaborated in paper II, allowing to compute outside-in the disk local thermal equilibrium with self-consistent advection and optically thin-to-thick transitions, in both radiation and gas supported regimes. The non-local inverse Compton cooling introduced by the external soft photons is computed by the BELM code. This additional term has a profound influence on JED solutions, allowing a smooth temperature transition from the outer SAD to the inner JED. We explore the full parameter space in disk accretion rate and transition radius, and show that the whole domain in X-ray fluxes and hardness ratios covered by standard XrB cycles is well reproduced by such hybrid configurations. Precisely, a reasonable combination of these parameters allows to reproduce the 3-200 keV spectra of five canonical XrB states. Along with X-ray signatures, JED-SAD configurations also naturally account for the radio emission whenever it is observed. By varying only the transition radius and the accretion rate, hybrid disk configurations combining an inner JED and an outer SAD are able to reproduce simultaneously the X-ray spectral states and radio emission of X-ray binaries during their outburst. Adjusting these two parameters, it is then possible to reproduce a full cycle. This will be shown in a forthcoming paper (paper IV).Comment: Accepted for publication in A&

“Savages Who Speak French”: Folklore, Primitivism and Morals in Robert Hertz

Hertz's analysis of the Alpine cult of Saint Besse apparently marks a break from his studies of death, sin and the left to folkloric studies. This analysis helps one to understand the personality of Robert Hertz. His sociological curiosity about folklore reveals his ambiguous position in social sciences at the beginning of the twentieth century. His text appears to be a variation from the Durkheimian norm, but another reading could suggest that Hertz continued and went beyond Durkheimian thought to something between sociology of the modern world and engaged socialism. Through this study, Hertz linked his political ideals, his work in ethnology and his desire for social involvement. The cult of Saint Besse perpetuated as much religious tradition as local identity. The Alpine people were presented in the text as wilful perpetuators of an ideal social order, whose loss for his contemporary city dwellers Hertz feared. The alpine Other, marked by a material and moral backwardness, represented for activist and socialist Hertz one of the paths of balanced social organization that stabilized the identity of a group across time if it fit rather well into the folkloric stereotypes of the beginning of the twentieth century. Finally, by linking events in Herz's life (e.g., the accidental Alpine death of his father), this article suggests that the legend of Saint Besse embodied several recurring motifs in Hertz' career: the accidental deaths of saint and father by falls, the military role of the saint and of Hertz himself

A comparison of wave mode identification techniques

The four point measurements available from the Cluster mission enable spatiotemporal effects in data sets to be resolved. One application of these multipoint measurements is the determination of the wave vectors and hence the identification of wave modes that exist within the plasma. Prior to multi-satellite missions, wave identification techniques were based upon the interpretation of observational data using theoretically defined relations. However, such techniques are limited by the quality of the data and the type of plasma model employed. With multipoint measurements, wave modes can be identified and their wave directions determined purely from the available observations. This paper takes two such methods, a phase differencing technique and k-filtering and compares their results. It is shown that both methods can resolve the k vector for the dominant mirror mode present in the data. The phase differencing method shows that the nature of the wave environment is constantly changing and as such both methods result in an average picture of the wave environment in the period analysed. The k-filtering method is able to identify other modes that are present

Chromatin: a tunable spring at work inside chromosomes

This paper focuses on mechanical aspects of chromatin biological functioning. Within a basic geometric modeling of the chromatin assembly, we give for the first time the complete set of elastic constants (twist and bend persistence lengths, stretch modulus and twist-stretch coupling constant) of the so-called 30-nm chromatin fiber, in terms of DNA elastic properties and geometric properties of the fiber assembly. The computation naturally embeds the fiber within a current analytical model known as the ``extensible worm-like rope'', allowing a straightforward prediction of the force-extension curves. We show that these elastic constants are strongly sensitive to the linker length, up to 1 bp, or equivalently to its twist, and might locally reach very low values, yielding a highly flexible and extensible domain in the fiber. In particular, the twist-stretch coupling constant, reflecting the chirality of the chromatin fiber, exhibits steep variations and sign changes when the linker length is varied. We argue that this tunable elasticity might be a key feature for chromatin function, for instance in the initiation and regulation of transcription.Comment: 38 pages 15 figure