5 research outputs found
Numerical Schemes for Multivalued Backward Stochastic Differential Systems
We define some approximation schemes for different kinds of generalized
backward stochastic differential systems, considered in the Markovian
framework. We propose a mixed approximation scheme for a decoupled system of
forward reflected SDE and backward stochastic variational inequality. We use an
Euler scheme type, combined with Yosida approximation techniques.Comment: 13 page
Condition UT et stabilité en loi des solutions d’équations différentielles stochastiques
Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitization in Melanoma Radiotherapy—From Animal Models to Clinical Trials
The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption as mechanisms of melanin radioprotection. Experimental models of melanoma in hamsters and in gerbils are described as well as their use in biochemical and radiobiological studies, including a spontaneously metastasizing ocular model. Some results from in vitro studies on the inhibition of melanogenesis are presented as well as radio-chelation therapy in experimental and clinical settings. In contrast to cutaneous melanoma, uveal melanoma is very successfully treated with radiation, both using photon and proton beams. We point out that the presence or lack of melanin pigmentation should be considered, when choosing therapeutic options, and that both the experimental and clinical data suggest that melanin could be a target for radiosensitizing melanoma cells to increase efficacy of radiotherapy against melanoma