The market of vocational professional education in Russia in the new economic conditions

Since the end of 2014, the Russian economy has undergone major changes. The crisis continued until 2018, followed by stabilization and short-term growth in 2018-2019. The emerging positive trends were interrupted by the pandemic. All this has had a signifcant impact on the vocational professional eduation market, both in quantitative and structural terms. The modern world is changing too fast, it is necessary to form the creative potential of a person. The article states that specialists’ adaptation mechanisms to new conditions should change with the help of advanced training, obtaining new knowledge and skills in all forms of education, including the system of vocational professional education. This means that the market of educational services formed by state, departmental and corporate educational institutions must respond to the demands of the economy and consumers of these services. Such advanced technologies and methods as online studying should be used along with and in combination with ofine classes. The conducted research has shown that large corporations allocate signifcant funds for the training and retraining of specialists corresponding to the level of technological development, capable of making effective management decisions. The authors of the article note that in the system of vocational professional education consumers of educational services are most interested in training programs related to management, marketing, information and computer technologies, which is quite consistent with the digital economy and the knowledge econom

Studying the pharmacokinetic parameters of new normothymic drug based on the complex of lithium citrate, aluminum oxide and polymethylsiloxane

For the treatment of bipolar affective disorders, lithium preparations are the most famous and effective. But the main problem with the use of lithium preparations is the narrow «therapeutic corridor». An urgent task is the creation of dosage forms of lithium with a slow release and a wide therapeutic range. The study object was a new normotymic drug based on lithium, aluminum oxide and polymethylsiloxane. Due to the new carrier matrix lithium is released from its porous structure gradually providing a prolonged effect and maintaining an optimal concentration in the blood which also helps to minimize side effects. The purpose of the study was to explore the pharmacokinetic parameters of a normotymic drug based on a complex lithium citrate, aluminum oxide and polymethylsiloxane (LOAP).Material and methods: for the assessment of pharmacokinetic parameters the method of atomic emission spectrometry with inductively coupled plasma and two-chamber modeling were used.Results and discussion. The pharmacokinetic data showed a linear nature of pharmacokinetics of the drug based on LOAP as the foundation of data of the lithium’s amount in the blood plasma of rabbits after intragastric administration at doses of 200, 400 and 800 mg/kg. The drug with intragastric administration at a dose of 800 mg/kg is well absorbed from the gastrointestinal tract, with bioavailability (F) 74 %. This dose shows the maximum increase of the area under the pharmacokinetic curve (AUC - 32787.1 (ng x h)/ ml), and indicators of elimination constant (Kel - 0.062 h-1), clearance (Cl - 0.09 l/(kg x h)), elimination half-life (T1/2p - 11.436 h) in comparison with other doses remain unchanged

STRATEGIES OF DEVELOPMENT FOR THE BANKING SECTOR IN THE SPHERE OF SMALL BUSINESS USING THE EXAMPLE OF VTB GROUP

In today’s world, small business is important element of market economy and the perspective direction of development of the banking sector. In the next years a number of quantitative and high-quality changes of development of small business which are connected with introduction of new platforms, formation of individual offers for clients, growth of the importance of digital channels in advance of a brand and involvement of new clients is expected. Small business of VTB Group has the potential for further growth. In article the actions within the development strategy considering current trends in the banking sector are offered

Safety front shock damper (shock absorber) to protect containers in emergency falling

The article presents a front shock damper (shock absorber) for protecting containers with flying machines against fractures in case of emergency falling in the process of transportation and operation. Two numerical methods are proposed to calculate the stress-strain state and acceleration braking of a shock absorber in case of a vertical fall and impact with a stationary concrete surface. The methods are based on the use of ANSYS Workbench 16.1. The first technique consists in determining the stress-strain state on the assumption of quasi-static loads. The second, dynamical, method makes it possible to determine the reaction of a shock absorber to its impact with the concrete surface depending on time. What makes our technique special is that we take into account plastic properties of a material and actual contacts between the damper components. The methods proposed are validated by the analytical solution of the differential equation of container motion with the shock absorber in the elastic strain range. The methods are illustrated by an example of calculating a given damper. The results obtained by three methods show quite good agreement taking into account the calculation error. It is established that the energy of the shock absorber plastic-elastic strain upon an impact is more than half of the kinetic energy of the shock absorber in motion. The dependence of the shock-absorber braking acceleration both on the size of the crumpled area and on the time is determined