Alone in a Crowd of Sheep: Asymmetric Perceptions of Conformity and Their Roots in an Introspection Illusion

The results of 5 studies showed that people see others as more conforming than themselves. This asymmetry was found to occur in domains ranging from consumer purchases to political views. Participants claimed to be less susceptible than their average peers to broad descriptions of social influences, and they also claimed to be less susceptible than specific peers to specific instances of conformity. These studies further demonstrated that this asymmetry is not simply the result of social desirability, but it is also rooted in people\u27s attention to introspective versus behavioral information when making conformity assessments. The participants displayed an introspection illusion, placing more weight on introspective evidence of conformity (relative to behavioral evidence) when judging their own susceptibility to social influence as opposed to someone else\u27s. Implications for self–other asymmetries, implicit social influence, and interpersonal conflict are discussed

NDV-induced apoptosis in absence of Bax; evidence of involvement of apoptotic proteins upstream of mitochondria

<p>Abstract</p> <p>Background</p> <p>Recently it was shown that following infection of HeLa cells with Newcastle disease virus (NDV), the matrix (M) protein binds to Bax and subsequently the intrinsic pathway of apoptosis is activated. Moreover, there was very little alteration on mRNA and protein levels of Bax and Bcl-2 after infection with NDV.</p> <p>Finding</p> <p>In order to further investigate the role of members of the Bcl-2 family, Bax-knockout and wild-type HCT116 cells were infected with NDV strain AF2240. Although both cells underwent apoptosis through the activation of the intrinsic pathway and the release of cytochrome c from mitochondria, the percentage of dead Bax-knockout cells was significantly lower than wt cells (more than 10% at 48 h post-infection). In a parallel experiment, the effect of NDV on HT29 cells, that are originally Bcl-2-free, was studied. Apoptosis in HT29 cells was associated with Bax redistribution from cytoplasm to mitochondria, similar to that of HeLa and wt HCT116 cells.</p> <p>Conclusion</p> <p>Although the presence of Bax during NDV-induced apoptosis contributes to a faster cell death, it was concluded that other apoptotic protein(s) upstream of mitochondria are also involved since cancer cells die whether in the presence or absence of Bax. Therefore, the classic Bax/Bcl-2 ratio may not be a major determinant in NDV-induced apoptosis.</p