Marginal resection and adjuvant strontium plesiotherapy in the management of feline eyelid malignant peripheral nerve sheath tumours: two cases

Case series summary Two cats with a marginally resected eyelid malignant peripheral nerve sheath tumour were treated with adjuvant strontium plesiotherapy a few weeks after surgery. The dose applied in both cases was 200 Gy to the surface, in five fractions, on a Monday–Wednesday–Friday basis. The treatment aimed to achieve a clinical margin of approximately 1 cm around the surgical scar and multiple application fields were required to cover such an area. Local recurrence was not seen in either case after 1330 and 645 days, respectively. Relevance and novel information The majority of periocular malignant peripheral nerve sheath tumours reported in the literature recur after surgery. In the two cases described in this report the combination of surgery and adjuvant plesiotherapy has been able to provide good local control with minimal toxicity. This multimodal approach could be considered as an alternative to aggressive surgery such as enucleation or exenteration

From the balcony looking difference: examining the cultural dimension of immigration in Castilla y Leon

Este artículo pretende exponer una serie de aspectos culturales considerados básicos para la integración de los inmigrantes. Debemos ser conscientes que la cultura es uno de los elementos más importantes de las sociedades, y sobre ellas nos socializan. El artículo analiza los diferentes aspectos que suelen ser un inconveniente para la integración de los inmigrantes en un país de acogida. Como son el desconocimiento del idioma, la conservación de los valores culturales de origen por no corresponderse con los de destino o la religión. Este artículo es producto de una investigación que hemos realizado en Castilla y León. This paper sets out a number of issues essential to the cultural integration of immigrants. We must be aware that culture is one of the most important elements of society, and we socialize them. This paper discusses the different aspects which are often considered inconvenient for the integration of immigrants in a host country. For instance ignorance of the language, the preservation of original cultural values because of lack of correspondence to the target culture and religion. This paper is an outcome of research we have done in Castilla and Leon

Frequentist versus Bayesian analyses: Cross-correlation as an approximate sufficient statistic for LIGO-Virgo stochastic background searches

Sufficient statistics are combinations of data in terms of which the likelihood function can be rewritten without loss of information. Depending on the data volume reduction, the use of sufficient statistics as a preliminary step in a Bayesian analysis can lead to significant increases in efficiency when sampling from posterior distributions of model parameters. Here we show that the frequency integrand of the cross-correlation statistic and its variance are approximate sufficient statistics for ground-based searches for stochastic gravitational-wave backgrounds. The sufficient statistics are approximate because one works in the weak-signal approximation and uses measured estimates of the auto-correlated power in each detector. Using analytic and numerical calculations, we prove that LIGO-Virgo's hybrid frequentist-Bayesian parameter estimation analysis is equivalent to a fully Bayesian analysis. This work closes a gap in the LIGO-Virgo literature, and suggests directions for additional searches

Modelo de informe de análisis cinemático en una carrera de 110m vallas

El objetivo de este estudio es mostrar un tipo de informe técnico - biomecánico con una metodología sencilla, para analizar la técnica individual de un corredor de 110 m vallas (extensible a otras especialidades atléticas). Este informe esta orientado al entrenador, y pretendemos que en él, se destaquen los aspectos más importantes de cada actuación. Los resultados del informe, se muestran en forma de fotoseriación de los eventos más importantes, y en tablas donde se pueden ver los tiempos de apoyo, los tiempos de vuelo, las longitudes de ataque, y de aterrizaje, y las velocidades medias entre zancadas, entre vallas

Fruit cell culture as a model system to study cell wall changes during strawberry fruit ripening

Strawberry (Fragaria x ananassa, Duch.) fruit is characterized by its fast ripening and soft texture at the ripen stage, resulting in a short postharvest shelf life and high economic losses. It is generally believed that the disassembly of cell walls, the dissolution of the middle lamella and the reduction of cell turgor are the main factors determining the softening of fleshy fruits. In strawberry, several studies indicate that the solubilisation and depolymerisation of pectins, as well as the depolymerisation of xyloglucans, are the main processes occurring during ripening. Functional analyses of genes encoding pectinases such as polygalacturonase and pectate lyase also point out to the pectin fraction as a key factor involved in textural changes. All these studies have been performed with whole fruits, a complex organ containing different tissues that differ in their cell wall composition and undergo ripening at different rates. Cell cultures derived from fruits have been proposed as model systems for the study of several processes occurring during fruit ripening, such as the production of anthocyanin and its regulation by plant hormones. The main objective of this research was to obtain and characterize strawberry cell cultures to evaluate their potential use as a model for the study of the cell wall disassembly process associate with fruit ripening. Cell cultures were obtained from cortical tissue of strawberry fruits, cv. Chandler, at the stages of unripe-green, white and mature-red. Additionally, a cell culture line derived from strawberry leaves was obtained. All cultures were maintained in solid medium supplemented with 2.5 mg.l-1 2,4-D and incubated in the dark. Cell walls from the different callus lines were extracted and fractionated to obtain CDTA and sodium carbonate soluble pectin fractions, which represent polyuronides located in the middle lamella or the primary cell wall, respectively. The amounts of homogalacturonan in both fractions were estimated by ELISA using LM19 and LM20 antibodies, specific against demethylated and methyl-esterified homogalacturonan, respectively. In the CDTA fraction, the cell line from ripe fruit showed a significant lower amount of demethylated pectins than the rest of lines. By contrast, the content of methylated pectins was similar in green- and red-fruit lines, and lower than in white-fruit and leaf lines. In the sodium carbonate pectin fraction, the line from red fruit also showed the lowest amount of pectins. These preliminary results indicate that cell cultures obtained from fruits at different developmental stages differ in their cell wall composition and these differences resemble to some extent the changes that occur during strawberry softening. Experiments are in progress to further characterize cell wall extracts with monoclonal antibodies against other cell wall epitopes.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Magnetic structure and phase diagram of TmB4

Magnetic structure of single crystalline TmB4 has been studied by magnetization, magnetoresistivity and specific heat measurements. A complex phase diagram with different antiferromagnetic (AF) phases was observed below TN1 = 11.7 K. Besides the plateau at half-saturated magnetization (1/2 MS), also plateaus at 1/9, 1/8 and 1/7 of MS were observed as function of applied magnetic field B//c. From additional neutron scattering experiments on TmB4, we suppose that those plateaus arise from a stripe structure which appears to be coherent domain boundaries between AF ordered blocks of 7 or 9 lattice constants. The received results suggest that the frustration among the Tm3+ magnetic ions, which maps to a geometrically frustrated Shastry-Sutherland lattice lead to strong competition between AF and ferromagnetic (FM) order. Thus, stripe structures in intermediate field appear to be the best way to minimize the magnetostatic energy against other magnetic interactions between the Tm ions combined with very strong Ising anisotropy.Comment: 4 pages, 4 figures, conference contribution - CSMAG 0

Sim-to-real reinforcement learning for deformable object manipulation

We have seen much recent progress in rigid object manipulation, but in- teraction with deformable objects has notably lagged behind. Due to the large con- figuration space of deformable objects, solutions using traditional modelling ap- proaches require significant engineering work. Perhaps then, bypassing the need for explicit modelling and instead learning the control in an end-to-end manner serves as a better approach? Despite the growing interest in the use of end-to-end robot learning approaches, only a small amount of work has focused on their ap- plicability to deformable object manipulation. Moreover, due to the large amount of data needed to learn these end-to-end solutions, an emerging trend is to learn control policies in simulation and then transfer them over to the real world. To- date, no work has explored whether it is possible to learn and transfer deformable object policies. We believe that if sim-to-real methods are to be employed fur- ther, then it should be possible to learn to interact with a wide variety of objects, and not only rigid objects. In this work, we use a combination of state-of-the-art deep reinforcement learning algorithms to solve the problem of manipulating de- formable objects (specifically cloth). We evaluate our approach on three tasks — folding a towel up to a mark, folding a face towel diagonally, and draping a piece of cloth over a hanger. Our agents are fully trained in simulation with domain randomisation, and then successfully deployed in the real world without having seen any real deformable objects

Nanostructural changes in cell wall pectins during strawberry fruit ripening assessed by atomic force microscopy

Rapid loss of firmness occurs during strawberry (Fragaria × ananassa Duch) ripening, resulting in a short shelf life and high economic losses. The disassembly of cell walls is considered the main responsible for fruit softening, being pectins extensively modified during strawberry ripening (Paniagua et al. 2014). Atomic force microscopy allows the analysis of individual polymer chains at nanostructural level with a minimal sample preparation (Morris et al., 2001). The main objective of this research was to compare pectins of green and red ripe strawberry fruits at the nanostructural level to shed light on structural changes that could be related to softening. Cell walls from strawberry fruits were extracted and fractionated with different solvents to obtain fractions enriched in a specific component. The yield of cell wall material, as well as the amount of the different fractions, decreased in ripe fruits. CDTA and Na2CO3 fractions underwent the largest decrements, being these fractions enriched in pectins supposedly located in the middle lamella and primary cell wall, respectively. Uronic acid content also decreased significantly during ripening in both pectin fractions, but the amount of soluble pectins, those extracted with phenol:acetic acid:water (PAW) and water increased in ripe fruits. Monosaccharide composition in CDTA and Na2CO3 fractions was determined by gas chromatography. In both pectin fractions, the amount of Ara and Gal, the two most abundant carbohydrates, decreased in ripe fruits. The nanostructural characteristics of CDTA and Na2CO3 pectins were analyzed by AFM. Isolated pectic chains present in the CDTA fraction were significantly longer and more branched in samples from green fruits than those present in samples obtained from red fruit. In spite of slight differences in length distributions, Na2CO3 samples from unripe fruits displayed some longer chains at low frequency that were not detected in ripe fruits. Pectin aggregates were more frequently observed in green fruit samples from both fractions. These results support that pectic chain length and the nanostructural complexity of the pectins present in CDTA and Na2CO3 fractions diminish during strawberry fruit development, and these changes, jointly with the loss of neutral sugars, could contribute to the solubilization of pectins and fruit softening. Paniagua et al. (2014). Ann Bot, 114: 1375-1383 Morris et al. (2001). Food Sci Tech 34: 3-10 This research was supported by FEDER EU Funds and the Ministerio de Educación y Ciencia of Spain (grant reference AGL2011-24814)Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech