1 research outputs found
Π€ΠΎΡΠΎ ΠΈ ΡΠΏΠ΅ΠΊΡΡΠ°Π»ΡΠ½ΡΠΉ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΎΠ±Π»Π°ΡΡΠΈ ΡΡΠ°Π²ΠΌΡ ΡΠΏΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° Π½Π° ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΠΌΠΎΠ΄Π΅Π»ΡΡ
The purpose of the work is to follow the dynamics of changes in fluorescent signals in the near-surface layers of tissue of injured areas of the back of laboratory animals, which will allow, by indirect evidence, to evaluate the information content of fluorescence diagnosis for subsequent possible diagnostic monitoring of photodynamic therapy of the spinal cord. The model animals were Wistar rats. Two types of contusions were modeled: pneumo-contusion and contusion by a falling load. Methylene blue and indocyanine green were used as photosensitizers. Fluorescence measurements were carried out by imaging and spectrometric methods. A stroboscopic fluorescence imager with an excitation wavelength of 630 nm was used to acquire fluorescence images. The LESA-01-BIOSPECΒ spectrometer with a He-Ne laser excitation allowed to obtain spectra. It was shown that both methods make it possible to estimate the fluorescence value of methylene blue and indocyanine green in the tissues under study. Moreover, the photographic method also allows to obtain the spatial distribution of fluorescence. The general trend found in the data is a more intense and uniform fluorescence of the dorsal region of rats with methylene blue and a less intense, but more contrasting distribution of indocyanine green. The presented methods are non-invasive, which makes them attractive for diagnostic use. However, due to the shallow depth of signal reception, the condition of the spine can be determined only indirectly, by the condition of the near-surface layers of tissue that accumulate the photosensitizer.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΠΏΡΠΎΡΠ»Π΅Π΄ΠΈΡΡΒ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΡΡ
Β ΡΠΈΠ³Π½Π°Π»ΠΎΠ²Β Π² ΠΏΡΠΈΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΡ
ΡΠ»ΠΎΡΡ
Β ΡΠΊΠ°Π½Π΅ΠΉΒ ΡΡΠ°Π²ΠΌΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΡΠ°ΡΡΠΊΠΎΠ² ΡΠΏΠΈΠ½Ρ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ, ΠΏΠΎ ΠΊΠΎΡΠ²Π΅Π½Π½ΡΠΌ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌ, ΠΎΡΠ΅Π½ΠΈΡΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π΄Π»Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅Π³ΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠ³ΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠΏΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°. ΠΠΎΠ΄Π΅Π»ΡΠ½ΡΠΌΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΠΌΠΈ Π±ΡΠ»ΠΈ ΠΊΡΡΡΡ ΠΠΈΡΡΠ°Ρ. ΠΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π»ΠΎΡΡ Π΄Π²Π° ΡΠΈΠΏΠ° ΠΊΠΎΠ½ΡΡΠ·ΠΈΠΉ: ΠΏΠ½Π΅Π²ΠΌΠΎΠΊΠΎΠ½ΡΡΠ·ΠΈΡ ΠΈ ΠΊΠΎΠ½ΡΡΠ·ΠΈΡ ΠΏΠ°Π΄Π°ΡΡΠΈΠΌ Π³ΡΡΠ·ΠΎΠΌ. Π€Π»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΡΠ΅ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡΒ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡΒ ΡΠΎΡΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌΒ Β ΠΈΒ ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌΒ Β ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΒ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌΠΈΒ ΠΌΠ΅ΡΠΈΠ»Π΅Π½ΠΎΠ²ΡΠΉΒ ΡΠΈΠ½ΠΈΠΉΒ ΠΈΒ ΠΈΠ½Π΄ΠΎΡΠΈΠ°Π½ΠΈΠ½ Π·Π΅Π»Π΅Π½ΡΠΉ. ΠΠ»Ρ ΡΠΎΡΠΎΡΠ΅Π³ΠΈΡΡΡΠ°ΡΠΈΠΈΒ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΠΎΠ³ΠΎΒ ΠΎΡΠ²Π΅ΡΠ°Β ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΡΡΒ ΡΡΡΠΎΠ±ΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΡΠΉΒ ΠΈΠΌΠΈΠ΄ΠΆΠ΅Ρ Ρ Π΄Π»ΠΈΠ½ΠΎΠΉ Π²ΠΎΠ»Π½Ρ Π²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΡ 630 Π½ΠΌ. Π‘ΠΏΠ΅ΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅Β ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡΒ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠ°Β ΠΠΠ‘Π-01-ΠΠΠΠ‘ΠΠΠ, Ρ Π²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΠ΅ΠΌ He-NeΒ Π»Π°Π·Π΅ΡΠΎΠΌΒ (632,8 Π½ΠΌ). ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ,Β ΡΡΠΎΒ ΠΎΠ±Π°Β ΠΌΠ΅ΡΠΎΠ΄Π°Β ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΒ ΠΎΡΠ΅Π½ΠΈΠ²Π°ΡΡΒ Π²Π΅Π»ΠΈΡΠΈΠ½ΡΒ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈΒ ΠΌΠ΅ΡΠΈΠ»Π΅Π½ΠΎΠ²ΠΎΠ³ΠΎΒ ΡΠΈΠ½Π΅Π³ΠΎΒ ΠΈ ΠΈΠ½Π΄ΠΎΡΠΈΠ°Π½ΠΈΠ½Π° Π·Π΅Π»ΡΠ½ΠΎΠ³ΠΎ Π² ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
ΡΠΊΠ°Π½ΡΡ
, Π° ΡΠΎΡΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠ°ΠΊΠΆΠ΅ ΠΏΠΎΠ»ΡΡΠΈΡΡ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ. ΠΠ±ΡΠ°Ρ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΡ, ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½Π°Ρ Π² ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
Π΄Π°Π½Π½ΡΡ
β Π±ΠΎΠ»Π΅Π΅ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½Π°Ρ ΠΈ ΡΠ°Π²Π½ΠΎΠΌΠ΅ΡΠ½Π°Ρ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ Π΄ΠΎΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ ΠΊΡΡΡ ΠΌΠ΅ΡΠΈΠ»Π΅Π½ΠΎΠ²ΡΠΌ ΡΠΈΠ½ΠΈΠΌ, ΠΈ ΠΌΠ΅Π½Π΅Π΅ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠ΅, Π½ΠΎ Π±ΠΎΠ»Π΅Π΅ ΠΊΠΎΠ½ΡΡΠ°ΡΡΠ½ΠΎΠ΅ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈΠ½Π΄ΠΎΡΠΈΠ°Π½ΠΈΠ½Π° Π·Π΅Π»ΡΠ½ΠΎΠ³ΠΎ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½Ρ, ΡΡΠΎ Π΄Π΅Π»Π°Π΅Ρ ΠΈΡ
ΠΏΡΠΈΠ²Π»Π΅ΠΊΠ°ΡΠ΅Π»ΡΠ½ΡΠΌΠΈ Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ. ΠΠ΄Π½Π°ΠΊΠΎ ΠΈΠ·-Π·Π° ΠΌΠ°Π»ΠΎΠΉ Π³Π»ΡΠ±ΠΈΠ½Ρ ΠΏΡΠΈΠ΅ΠΌΠ° ΡΠΈΠ³Π½Π°Π»Π° ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ½ΠΎΡΠ½ΠΈΠΊΠ° ΠΌΠΎΠΆΠ½ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π»ΠΈΡΡ ΠΊΠΎΡΠ²Π΅Π½Π½ΠΎ, ΠΏΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΏΡΠΈΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΡ
ΡΠ»ΠΎΠ΅Π² ΡΠΊΠ°Π½Π΅ΠΉ, Π½Π°ΠΊΠ°ΠΏΠ»ΠΈΠ²Π°ΡΡΠΈΡ
ΡΠΎΡΠΎΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡ