РАСПРОСТРАНЕНИЕ И ПРОФИЛАКТИКА ПИРОПЛАЗМИДОЗОВ КРУПНОГО РОГАТОГО СКОТА В РЕСПУБЛИКЕ ДАГЕСТАН

Objective of research: Determination of the efficiency of 5% concentration Diminazene aceturate at the dose of 0.25 mg/kg body in combination with polyethylene glycol solution applied against piroplasmidosis in cattle.Materials and methods: Trial of the new method of prolonged chemoprevention was carried out in one of the farms of Dagestan, which is unfavorable for piroplasmidosis. Aceturate contained in this drug rapidly inhibits DNA in cells of blood parasites, which leads to their death within several hours. Diminazene aceturate proved to be effective against piroplasmidosis, babesiosis, taleriosis, hemosporidosis of animals. The experiment was conducted on 30 head of cattle divided into 3 groups 10 head in each. Animals of two groups received the preparation and prolongator at the dose of 0,25 mg/kg in the 15% aqueous solutions of polyethylene glycols (PEG), and at the dose of 0,25 mg/kg in the 20% aqueous solutions; the third group served as a control (received the preparation without prolongator). Efficacy of the method was estimated by periodic examination of blood smears from experimental animals for plasmodia in erythrocytes and synchronous measurement of body temperature of animals.Results and discussion: It was found that the method of prolonged chemoprophylaxis applied against piroplasmidosis in animals (at the dose of 5 ml per 100 kg body weight, 6 times every 25 days) enables disease prevention during the whole disease season. Such method allows reducing the number of treatments from 24 to 12-13 times in a season. In addition, data on the distribution of hemosporidia infections among the cattle in the Republic of Dagestan were clarified.Цель исследования — изучение эффективности препарата ДАЦ (диминацена ацетурат) в сочетании с 20%-ным раствором полиэтиленгликоля при пироплазмидозах крупного рогатого скота.Материалы и методы. Для испытания нового метода пролонгированной химиопрофилактики был проведен производственный опыт в одном из хозяйств Дагестана, неблагополучном по пироплазмидозу.Входящий в состав препарата ДАЦ диминацена ацетурат быстро ингибирует ДНК клеток паразитов крови, что приводит к их гибели в течение нескольких часов. Препарат ДАЦ является эффективным средством для животных при заболевании пироплазмозом, бабезиозом, тейлериозом, гемоспоридиозом.Опыт проведен на 30 головах крупного рогатого скота, которых разделили на 3 группы по 10 голов в каждой. Животным двух групп вводили препарат и пролонгатор в дозах: 0,25 мг/кг в 15%-ном водном растворе ПЭГ и в дозе 0,25 мг/кг в 20%-ном водном растворе, третья группа служила контролем (препарат без пролонгатора).Эффективность метода определяли путем периодического исследования мазков периферической крови опытных животных на наличие плазмидий в эритроцитах, для мониторинга, синхронно с исследованиями, измеряли температуру тела животных.Результаты и обсуждение. Установлено, что применение метода пролонгированной химиопрофилактики пироплазмоза у крупного рогатого скота в объеме 5 мл на 100 кг массы тела через каждые 25 дней (шестикратно) позволяет предотвратить болезнь в течение всего сезона заболеваний. Такой метод обработки позволяет в последующем сократить количество обработок животных за сезон с 24 до 12-13 раз. Также были уточнены данные по распространению пироплазмидозов крупного рогатого скота в девяти районах Республики Дагестан

DISTRIBUTION AND PREVENTION OF HAEMOSPORIDIA INFECTIONS AMONG THE CATTLE IN THE REPUBLIC OF DAGESTAN

Objective of research: Determination of the efficiency of 5% concentration Diminazene aceturate at the dose of 0.25 mg/kg body in combination with polyethylene glycol solution applied against piroplasmidosis in cattle.Materials and methods: Trial of the new method of prolonged chemoprevention was carried out in one of the farms of Dagestan, which is unfavorable for piroplasmidosis. Aceturate contained in this drug rapidly inhibits DNA in cells of blood parasites, which leads to their death within several hours. Diminazene aceturate proved to be effective against piroplasmidosis, babesiosis, taleriosis, hemosporidosis of animals. The experiment was conducted on 30 head of cattle divided into 3 groups 10 head in each. Animals of two groups received the preparation and prolongator at the dose of 0,25 mg/kg in the 15% aqueous solutions of polyethylene glycols (PEG), and at the dose of 0,25 mg/kg in the 20% aqueous solutions; the third group served as a control (received the preparation without prolongator). Efficacy of the method was estimated by periodic examination of blood smears from experimental animals for plasmodia in erythrocytes and synchronous measurement of body temperature of animals.Results and discussion: It was found that the method of prolonged chemoprophylaxis applied against piroplasmidosis in animals (at the dose of 5 ml per 100 kg body weight, 6 times every 25 days) enables disease prevention during the whole disease season. Such method allows reducing the number of treatments from 24 to 12-13 times in a season. In addition, data on the distribution of hemosporidia infections among the cattle in the Republic of Dagestan were clarified