Management of the Energy Business in the Countries with Developing Economies in the Conditions of the Integration Processes

The present article describes the problems, which are connected with consequences of the ever-increasing influence of the world integration processes upon the national economies in the sphere of energy business. At the global level, this influence is evident as the dependency of governmental budgets of the oil and gas sector from commercial interests of the international corporations, which are owners of the production enterprises in the countries with developing economies. Moreover, it creates new vectors and trends of development both for entire industry and for power markets particularly. Goal of this article is to test this hypothesis on the basis of the corporate structured approach with the help of statistical and financial methods and instruments. Another goal of this article is to determine degree of influence of corporations upon national economies of developing countries in the power-generating sector. As the result, we have succeeded in improvement of the LRD (Limited Risk Distributor), which is the model of the corporate business management. This model is topical one and it is applicable for any energy companies within corporate entities (holdings and groups of companies) in the countries with developing economies. Keywords: energy business; emerging markets; corporations; LRD management business model. JEL Classifications: F23; F36; G34; O13 DOI: https://doi.org/10.32479/ijeep.778

In Vitro Cell Models for Ophthalmic Drug Development Applications

© Sara Shafaie et al. 2016; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.Tissue engineering is a rapidly expanding field that aims to establish feasible techniques to fabricate biologically equivalent replacements for diseased and damaged tissues/organs. Emerging from this prospect is the development of in vitro representations of organs for drug toxicity assessment. Due to the ever-increasing interest in ocular drug delivery as a route for administration as well as the rise of new ophthalmic therapeutics, there is a demand for physiologically accurate in vitro models of the eye to assess drug delivery and safety of new ocular medicines. This review summarizes current existing ocular models and highlights the important factors and limitations that need to be considered during their use.Peer reviewe

Genome-wide analysis identifies novel susceptibility loci for myocardial infarction

AIMS: While most patients with myocardial infarction (MI) have underlying coronary atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought to address the hypothesis that some of the genetic factors which establish atherosclerosis may be distinct from those that predispose to vulnerable plaques and thrombus formation. METHODS AND RESULTS: We carried out a genome-wide association study for MI in the UK Biobank (n∼472 000), followed by a meta-analysis with summary statistics from the CARDIoGRAMplusC4D Consortium (n∼167 000). Multiple independent replication analyses and functional approaches were used to prioritize loci and evaluate positional candidate genes. Eight novel regions were identified for MI at the genome wide significance level, of which effect sizes at six loci were more robust for MI than for CAD without the presence of MI. Confirmatory evidence for association of a locus on chromosome 1p21.3 harbouring choline-like transporter 3 (SLC44A3) with MI in the context of CAD, but not with coronary atherosclerosis itself, was obtained in Biobank Japan (n∼165 000) and 16 independent angiography-based cohorts (n∼27 000). Follow-up analyses did not reveal association of the SLC44A3 locus with CAD risk factors, biomarkers of coagulation, other thrombotic diseases, or plasma levels of a broad array of metabolites, including choline, trimethylamine N-oxide, and betaine. However, aortic expression of SLC44A3 was increased in carriers of the MI risk allele at chromosome 1p21.3, increased in ischaemic (vs. non-diseased) coronary arteries, up-regulated in human aortic endothelial cells treated with interleukin-1β (vs. vehicle), and associated with smooth muscle cell migration in vitro. CONCLUSIONS: A large-scale analysis comprising ∼831 000 subjects revealed novel genetic determinants of MI and implicated SLC44A3 in the pathophysiology of vulnerable plaques

Study of correlation between bone mineral density and clinical and laboratory indices of rheumatoid arthritis activity

Objective. To study association between bone mineral density (BMD) and clinical and laboratory indices of rheumatoid arthritis (RA) activity Material and methods. 60 women with RA who had not received glucocorticoid and anti-osteoporotic therapy were included. 30 had unchanged menstrual cycle and 30 were postmenopausal. Lumbar spine BMD and proximal femur was studied with double radiological absorptiometry (QDR 1000 Hologic apparatus). W.Wilke indices were used to characterize activity and severity of RA. CRP level was evaluated with quantitative immunoenzyme method. Results. Significant negative association was revealed between spine and femoral neck BMD and RA severity so as between femoral neck BMD and CRP level in pts with unchanged menstrual cycle and in postmenopausal pts

PALMAR-AND-PLANTAR ERYTHRODYSESTHESIA IS A SERIOUS COMPLICATION AFTER CAPECYTABIN: OUR OWN EXPERIENCE

Some drugs used in chemotherapy of patients with malignant tumors, together with the definite efficiency, is capable of inducing some side effects. In particular, while using capecytabin, development of severe complication – palmar-plantar erythrodysesthesia – is quite possible. Our own observation of this complication is presented in the article

Gas Flowmeter Based on Vibrating Wires

The paper proposes a new type of gas flowmeters based on measurements of the deformations of the thermal field of the heater in the presence of a flow using vibrating wires. The advantage of such flowmeters as compared with the known ones using a similar thermal principle of operation is the improved accuracy of temperature measurements compared to resistance thermometers or thermocouples. The use of thin wires can also increase the speed of flowmeters. The use of wires 20-30 mm long allows the creation of wide-aperture inlet holes for gas streams. A natural property of the developed flowmeters is also in their bidirectionality. A sample of a flowmeter based on vibrating wires was made and the calibration experiments were carried out. An experiment was carried out in which a flowmeter was used to measure the acceleration