COGNITIVE IMPAIRMENTS AFTER STROKE

Thirty-two patients (mean age 53.912.4 years) with prior stroke were examined to clarify the pattern and degree of cognitive impairments depending on the site of a lesion. A control group comprised 32 subjects (mean age 52.112.9 years) without nervous system pathology. The authors made a complete clinical study to evaluate the neurological and mental status, a standardized interview, and A.R. Luria's neuropsychological tests. The patients with prior stroke were found to have lower values of auditory-verbal short-term and long-term memory, impaired concentration and voluntary attention scope. Mild cognitive disorders were established in middle-aged patients and moderate cognitive disorders of amnestic multifunctional type were in elderly patients. Auditory-verbal memory, visual gnosis, and some speech-related thought functions were impaired when in the involvement of the temporal and posterior frontal lobes in patients with prior stroke in the middle cerebral artery bed. Impaired visual image recognition and lower visual voluntary attention were detected in patients with prior stroke in the anterior and posterior cerebral arteries

THE RATE OF METABOLIC SYNDROME AND COMORBIDITIES IN PATIENTS WITH GOUT: DATA OF A MULTICENTER TRIAL

Objective: to study the rate of metabolic syndrome (MS) and its components among gout patients in different regions of the Russian Federation. Subjects and methods. This cross-sectional multicenter study enrolled 2277 gout patients, including 1963 (86.2%) men and 314 (13.8%) women, from 12 independent medical centers in different regions of the Russian Federation. The patients over 18 years of age who met the classification criteria for gout, elaborated by S. Wallace et al., were included. The diagnosis of MS was established on the basis of Adult Treatment Panel III (ATP III) criteria. The presence of MS, its individual components and comorbidities were recorded. Results. The total rate of MS in the patients with gout was 57%; however, it varied substantially (from 15 to 77%) in different centers. Among the comorbidities, arterial hypertension was most common (in three fourths of the patients), coronary heart disease (CHD) and type 2 diabetes mellitus were less common (43 and 25%, respectively); 15% of the patients had sustained myocardial infarction, renal and cardiac failure was also observed in 15%. In the gout patients, MS was associated with the presence of CHD. Conclusion. The patients with gout were observed to have a high rate of MS (57%), its components, and cardiovascular diseases. The findings suggest that there is a relationship between the presence of MS and the development of CHD