19 research outputs found
Increased expression of endothelial lipase in symptomatic and unstable carotid plaques
The aim of this study was to evaluate endothelial lipase (EL) protein expression in advanced human carotid artery plaques (HCAP) with regard to plaque (in)stability and the incidence of symptoms. HCAP were collected from 66 patients undergoing carotid endarterectomy (CEA). The degree of plaque (in)stability was estimated by ultrasound and histology. In HCAP sections, EL expression was determined by immunostaining and the intensity was assessed on a semi-quantitative scale (low: <25%, high: >25% positive cells). Monocytes and macrophages in adjacent HCAP sections were stained with a CD163 specific antibody. High EL staining was more prevalent in histologically unstable plaques (in 33.3% of fibrous plaques, 50% of ulcerated non-complicated plaques and 79.2% of ulcerated complicated plaques; χ2 test, p = 0.004) and in the symptomatic group (70.8 vs. 42.9% in the asymptomatic group; χ2 test, p = 0.028). The majority of EL immunostaining was found in those HCAP regions exhibiting a strong CD163 immunostaining. EL in HCAP might be a marker and/or promoter of plaque instability and HCAP-related symptomatology
Cerebral Infarct in Patients with Bilateral High-Grade Internal Carotid Artery Stenosis: Analysis by Diffusion-Weighted Imaging
Transatlantic Differences in Management of Carotid Stenosis: BRIDGing the Gap in StrokE Management (BRIDGE) Project
978 Cognitive impairment and vascular changes in patients receiving antiandrogen therapy for locally advanced prostatic cancer
Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment
Polymorphism of Apoprotein E (APOE), Methylenetetrahydrofolate Reductase (MTHFR) and Paraoxonase (PON1) Genes in Patients with Cerebrovascular Disease
Examples of dramatic failures and their effectiveness in modern surgical disciplines: can we learn from our mistakes?
Fetal carotid-vertebrobasilar anastomoses: persistent hypoglossal artery associated with further variations of the circle of Willis
SiPP (Stroke in Pregnancy and Postpartum): A prospective,observational, international, multicentre study on pathophysiological mechanisms, clinical profile, management and outcome of cerebrovascular diseases in pregnant and postpartum women
Abstract
Rationale: Cerebrovascular diseases associated with pregnancy and postpartum period are uncommon; however, they can have an important impact on health of both women and foetus or newborn. Aims: To evaluate the frequency, characteristics and management of cerebrovascular events in pregnant/postpartum women, to clarify pathophysiological mechanisms underlying the occurrence of these events including biomolecular
aspects, and to assess the short- and long-term cerebrovascular and global cardiovascular outcome of these patients,their predictors and infant outcome.
Methods and design: This is an observational, prospective, multicentre, international case–control study. The study will include patients with cerebrovascular events during pregnancy and/or within six months after delivery. For each included case, two controls will be prospectively recruited: one pregnant or puerperal subject without any history of cerebrovascular event and one non-pregnant or non-puerperal subject with a recent cerebrovascular event. All controls
will be matched by age, ethnicity and type of cerebrovascular event with their assigned cases. The pregnant controls
will be matched also by pregnancy weeks/trimester. Follow-up will last 24 months for the mother and 12 months for the infant.
Summary: To better understand causes and outcomes of uncommon conditions like pregnancy/postpartum-related
cerebrovascular events, the development of multisite, multidisciplinary registry-based studies, such as the Stroke in Pregnancy and Postpartum study, is needed in order to collect an adequate number of patients, draw reliable conclusions
and give definite recommendations on their management.
© European Stroke Organisation 2019