154 research outputs found
Medication errors associated with carbapenems
Purpose. The purpose of this study was to discover the prevalence and types of medication errors associated with the use of carbapenems. Materials and methods. We analyzed 161 spontaneous reports concerning adverse drug reactions associated with the carbapenems. All the reports were submitted to the Russian pharmacovigilance database between 01.01.2012 and 01.08.2014. Approved prescribing drug information, standards of medical care and practical guidelines for certain conditions were used to identify medication errors associated with specific products. Results. The prevalence of medication errors associated with the use of carbapenems was 24,8%. The reporters indicated medication error-related term only in 5,0% of these cases. The most common types of identified medication errors (44,0%) were deviations from the recommended dosing scheme, in most cases (20,0%) medication errors resulted from wrong frequency of administration of the antibiotic. Conclusions. The results of this study show that the reporters rarely recognize and identify medication errors. We suggest emphasizing the importance of compliance with the dosage regimen of antibiotics; the frequency of administration of carbapenems is critical
EPIDEMIOLOGY OF PRIMARY HIP ARTHROPLASTY: REPORT FROM REGISTER OF VREDEN RUSSIAN RESEARCH INSTITUTE OF TRAUMATOLOGY AND ORTHOPEDICS
The  paper  presents  data  analysis  of the  Hip  Arthroplasty Register  of Vreden  Russian  Research  Institute of Traumatology and Orthopedics, namely information on 37373 primary THA performed at the Vreden Institute and at several other orthopedic centers and 1200 hip replacements at other hospitals of St. Petersburg.There were 1.5 times more women in the studied cohort than men. A significant predominance of women with dysplastic osteoarthritis (72.4%) and rheumatoid arthritis (82.1%) was reported. A male predominance was noted in patients with secondary osteoarthritis (53.1%), post-traumatic changes of hip (61.0%) and osteonecrosis of the femoral head (68.6 %). The mean age of patients was 58.0±12.9 years (95% CI from 57.9 to 58.1, median 59 years). Age data of the study revealed that patients were 10-12 years younger than reported in the national arthroplasty registers of other countries.Total hip arthroplasty was performed in the absolute majority of patients – 37295 cases (99,8%). Uncemented implants were used in 59.3% of cases, hybrid – in 29.6%, cemented – in 10.2%, reverse-hybrid – in 0.9% of all patients. The most common bearing used was metal on crosslink polyethylene, which was applied in 50.1% of all cases of arthroplasty. The type of fixation of the implant, and the use of different bearings varied in different age groups. The paper presents not only the absolute numbers of the data, but also demonstrated the dynamics of the changes in time starting from 2007.The present epidemiological study does not claim the absolute completeness of the presented data, but contains the analysis of the large number of cases, comparable with follow-ups of patients in some national registers of certain European countries. The authors analyzed about 10% of all cases of hip replacements performed on the territory of the Russian Federation in ten-year period
Mesomorphism of Dichotomous Compounds; X-Ray Diffraction Analysis of 4-Chlorophenyl Hexadecyl Ether
X-Ray Diffraction and Thermographic Study of Mesomorphic 4-Acylphenyl 4'-Nonyloxybenzoate CH3C(O)C6H4–OC(O)–C6H4–OC9H19
Crystal Packing of Potentially Mesomorphic Azobenezene Derivatives R1–C6H4–N=N–C6H4–R2 (R1, R2 = CH3COO, C2H5O; CH2=C(CH3)COO, C2H5; C6H13COO, C2H5O)
X-ray diffraction study of p-(alkoxybenzylidene)-p′-toluidines: Crystal and molecular structure of C10H21O-C6H4-CH=N-C6H4-CH3
Photo- and electroluminescent properties of zinc(II) complexes with tetradentate Schiff bases, derivatives of salicylic aldehyde
International audienceIt is studied how the introduction of various substituents into the composition of organic ligands affects the photoluminescence spectra of new zinc(II) complexes with tetradentate Schiff bases H2L (derivatives of salicylic aldehyde (H2SAL1, H2SAL2) and o-vanillin (H2MO1, H2MO2) with ethylenediamine and o-phenylenediamine) in the form of bulk solids and thin films. It is demonstrated that the emission spectra of bulk solid complexes without o-phenylenediamine bridges (ZnSAL1 and ZnMO1) contain additional long-wavelength bands compared to the spectra of corresponding thin films. In the case of films obtained from [ZnSAL1]2 dimer complexes, the long-wavelength band is dominant. At the same time, the photoluminescence spectra of ZnSAL2 and ZnMO2 complexes with o-phenylenediamine bridges are similar in the case of solid samples and thin films. The electroluminescent properties of organic light-emitting diodes (OLEDs) with the ITO/α-NPD/ZnL/Ca:Al structure are studied. The bathochromic shift of the electroluminescence peaks of OLEDs with respect to the photoluminescence spectra of bulk solid samples and thin films is probably related to the formation of exciplexes at the α-NPD/ZnL interface. The electroluminescence spectra of OLEDs based on [ZnSAL1]2 show a hypsochromic shift of the emission maximum, which can be caused by a shift of the recombination region into the α-NPD layer
Effect of the composition of an acetonitrile-dimethyl sulfoxide solvent on stability of the silver(I) complexes with 18-crown-6 ether
Crystal and molecular structure of 4(3-acryloyloxy)octyloxy- and 4(3-acryloyloxy)hexyloxy-4′-cyanobiphenyls
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