A systematic review and meta-analysis of neurological soft signs in relatives of people with schizophrenia

<p>Abstract</p> <p>Background</p> <p>Neurological soft signs are subtle but observable impairments in motor and sensory functions that are not localized to a specific area of the brain. Neurological soft signs are common in schizophrenia. It has been established that soft signs meet two of five criteria for an endophenotype, namely: association with the illness, and state independence. This review investigated whether soft signs met a further criterion for an endophenotype, namely familial association. It was hypothesized that if familial association were present then neurological soft signs would be: (a) more common in first-degree relatives of people with schizophrenia than in controls; and (b) more common in people with schizophrenia than in their first-degree relatives.</p> <p>Method</p> <p>A systematic search identified potentially eligible studies in the EMBASE (1980-2011), OVID - MEDLINE (1950-2011) and PsycINFO (1806-2011) databases. Studies were included if they carried out a three-way comparison of levels of soft signs between people with schizophrenia, their first-degree relatives, and normal controls. Data were extracted independently by two reviewers and cross-checked by double entry.</p> <p>Results</p> <p>After screening 8678 abstracts, seven studies with 1553 participants were identified. Neurological soft signs were significantly more common in first-degree relatives of people with schizophrenia than in controls (pooled standardised mean difference (SMD) 1.24, 95% confidence interval (c.i) 0.59-1.89). Neurological soft signs were also significantly more common in people with schizophrenia than in their first-degree relatives (SMD 0.92, 95% c.i 0.64-1.20). Sensitivity analyses examining the effects of age and group blinding did not significantly alter the main findings.</p> <p>Conclusions</p> <p>Both hypotheses were confirmed, suggesting that the distribution of neurological soft signs in people with schizophrenia and their first-degree relatives is consistent with the endophenotype criterion of familial association.</p

Population, resources, and environment: Implications of human behavioral ecology for conservation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43481/1/11111_2005_Article_BF02207996.pd

Uso e diversidade de plantas medicinais em Santo Antonio do Leverger, MT, Brasil

O presente trabalho tem como objetivo fazer o levantamento etnobotânico de plantas com usos terapêuticos no município de Santo Antonio do Leverger, MT, e estimar a diversidade de espécies usadas. Foram entrevistados residentes adultos de ambos os sexos, junto com os quais foram coletadas as plantas, depositadas no Herbarium Rioclarense (HRCB). Identificaram-se 228 espécies, pertencentes a 73 famílias; 56% delas crescem espontaneamente em ambientes naturais ou antropicamente modificados, 41% são cultivadas e 3% são compradas. Os índices de diversidade encontrados comparam-se aos mais altos registrados na literatura para plantas medicinais em outras áreas tropicais. A riqueza e diversidade das plantas espontâneas podem espelhar até certo ponto a riqueza e diversidade de espécies no ambiente, enquanto tais parâmetros para as espécies cultivadas estariam mais ligados a fatores sócio-culturais que promovam a introdução de novas plantas e informações de uso a partir de fontes externas. Sugere-se que quando comunidades tradicionais se tornam mais expostas à sociedade nacional, o número de espécies e o conhecimento acerca de seu uso podem sofrer inicialmente um acréscimo, por aportes externos; mas, com o aprofundamento do contato, e as mudanças sócio-econômicas decorrentes, a tendência será que as plantas usadas com fins terapêuticos restrinjam-se às espécies cultivadas e invasoras cosmopolitas.<br>This work describes an ethnobotanical survey of medicinal plants in Santo Antonio do Leverger Municipality, Mato Grosso State, Brazil and estimates the diversity of species with therapeutic use. Adult dwellers, male and female, were interviewed and plant gathering undertaken with their assistance. Voucher specimens were deposited at the Herbarium Rioclarense (HRCB). 228 species were identified, belonging to 73 families; 56% of the species grow spontaneously in natural and anthropically modified habitats, 41% are cultivated and 3% are purchased. Diversity indexes are among the highest ones reported in literature for medicinal plants in other tropical areas. Richness and diversity of spontaneous species may mirror to certain extent environmental richness and diversity, whereas for cultivated species, these measures could be linked to socio-cultural factors enhancing introduction of new plants and use information from outside the area. It is suggested that when traditional communities become more exposed to society at large, species number and knowledge about their use may at first increase, by foreign input; but, with the socio-economic changes that come about over time, plants used for therapeutic aims will be limited to the cultivated species and cosmopolite weeds