100 research outputs found
Calibration of Troitsk nu-mass detector readout electronics by signal digital filters
We present the results of tuning and calibration of the detector electronics
in the signal digitization mode. The goal of the experiment is to search for a
possible sterile neutrino signature in tritium beta-decay. The read-out
electronics work in direct oscilloscope mode, which requires to optimize time
frame the with the goal to minimize noise and energy resolution. We use a
7-pixel silicon drift detector (SDD) and a CMOS charge sensitive preamplifier
with very low integration capacitor. Amplifier forms a slowly rising output
shape and operates in pulse-reset mode. The 125 MHz ADC digitizes the signals.
Using calibration data from Fe55 and Am241 gamma sources we check triangular
and trapezoid digital filters to obtain the best noise and energy resolution
performance. We are also examining the option to differentiate the output
signal.Comment: 9 pages, 8 figure
LAPAROSCOPIC SURGERY IN TREATMENT OF ENDOMETRIAL CANCER (RESULTS OF 7-YEAR CLINICAL EXPERIENCE AT THE N.N. PETROV NATIONAL MEDICAL RESEARCH ONCOLOGY CENTER)
Introduction. The main method of treatment of endometrial cancer, the most common oncological disease, is surgery. Introduction of high-tech operations into gynecological practice promoted active use of laparoscopy in treatment of malignant tumors of the endometrium.Objective. To evaluate effectiveness of video endoscopic surgery in treatment of endometrial cancer.Materials and methods. In the period from 2010 to 2016, 1127 patients with endometrial cancer underwent surgery using video endoscopic complex with high resolution cameras at the N.N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia.Results.Β Using video endoscopic technology, excision of the uterus with appendages was performed in 588 (52.3 %) patients, excision of the uterus with appendages and pelvic lymph node dissection was performed in 523 (46.4 %) patients including 16 (1.4 %) patients with serous and papillary serous forms of endometrial cancer who also underwent omentectomy. No intraoperative complications were observed. In the majority of patients, postoperative period was characterized by early activization, satisfactory intestinal peristalsis on day 1, minimal complications, absence of contraindications for adjuvant beam therapy.Conclusion. Video endoscopic technology is a modern method of surgical treatment allowing to perform the full scope of planned radical surgical intervention in patients with endometrial cancer irrespectively of age and concomitant disorders with minimal traumatization, risk of intraand postoperative complications as well as favorable and fast rehabilitation period
ΠΡΠΊΡΡΡΡΠ²Π΅Π½Π½Π°Ρ Π²Π΅Π½ΡΠΈΠ»ΡΡΠΈΡ Π»Π΅Π³ΠΊΠΈΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΌΠΎΡΠ±ΠΈΠ΄Π½ΡΠΌ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠΈ Π»Π°ΠΏΠ°ΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΡ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΡΡ Π² ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ Π’ΡΠ΅Π½Π΄Π΅Π»Π΅Π½Π±ΡΡΠ³Π° (ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ)
Β Β The literature review is devoted to the peculiarities of artificial lung ventilation (ALV) in patients with morbid obesity during laparoscopic oncosurgical interventions in the Trendelenburg position. At present, there are no consensus recommendations on the choice of the optimal ALV mode during anesthesia in this area of oncosurgery. When analyzing data obtained from other types of operations, there was no impression that there were significant advantages of any ALV modes, both with volume and pressure control. However, high values of positive end-expiratory pressure (PEEP) have the most evidence of benefit in this category of patients, and the inversion of the duration of the respiratory cycle phases without creating a high PEEP can help reduce the risk of lung damage when all other ALV techniques do not allow for adequate oxygenation.Β Β ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π²Π΅Π½ΡΠΈΠ»ΡΡΠΈΠΈ Π»Π΅Π³ΠΊΠΈΡ
(ΠΠΠ) Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΌΠΎΡΠ±ΠΈΠ΄Π½ΡΠΌ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠΈ Π»Π°ΠΏΠ°ΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΠ½ΠΊΠΎΡ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π°Ρ
Π² ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ Π’ΡΠ΅Π½Π΄Π΅Π»Π΅Π½Π±ΡΡΠ³Π°. Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΡΠΎΠ³Π»Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ Π²ΡΠ±ΠΎΡΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΠΆΠΈΠΌΠ° ΠΠΠ ΠΏΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ Π°Π½Π΅ΡΡΠ΅Π·ΠΈΠΈ Π² ΡΡΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ ΠΎΠ½ΠΊΠΎΡ
ΠΈΡΡΡΠ³ΠΈΠΈ ΠΎΡΡΡΡΡΡΠ²ΡΡΡ. ΠΡΠΈ Π°Π½Π°Π»ΠΈΠ·Π΅ Π΄Π°Π½Π½ΡΡ
, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΏΡΠΈ Π΄ΡΡΠ³ΠΈΡ
Π²ΠΈΠ΄Π°Ρ
ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΉ, Π½Π΅ ΡΠ»ΠΎΠΆΠΈΠ»ΠΎΡΡ Π²ΠΏΠ΅ΡΠ°ΡΠ»Π΅Π½ΠΈΡ ΠΎ Π½Π°Π»ΠΈΡΠΈΠΈ Π·Π½Π°ΡΠΈΠΌΡΡ
ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ² ΠΊΠ°ΠΊΠΈΡ
-Π»ΠΈΠ±ΠΎ ΡΠ΅ΠΆΠΈΠΌΠΎΠ² ΠΠΠ β ΠΊΠ°ΠΊ Ρ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΏΠΎ ΠΎΠ±ΡΠ΅ΠΌΡ, ΡΠ°ΠΊ ΠΈ ΠΏΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΡ. Π’Π΅ΠΌ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ Π±ΠΎΠ»ΡΡΠ΅ Π²ΡΠ΅Π³ΠΎ Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΡΡΠ² Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΠΏΠΎΠ»ΡΠ·Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Ρ ΡΠ°ΠΊΠΎΠΉ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΠΌΠ΅ΡΡ Π²ΡΡΠΎΠΊΠΈΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΡ Π² ΠΊΠΎΠ½ΡΠ΅ Π²ΡΠ΄ΠΎΡ
Π° (ΠΠΠΠ), ΠΈΠ½Π²Π΅ΡΡΠΈΡ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΠ°Π· Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Π° Π±Π΅Π· ΡΠΎΠ·Π΄Π°Π½ΠΈΡ Π²ΡΡΠΎΠΊΠΎΠ³ΠΎ ΠΠΠΠ ΠΌΠΎΠΆΠ΅Ρ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΠΈΡΠΊΠ° ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ Π»Π΅Π³ΠΊΠΈΡ
Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
, ΠΊΠΎΠ³Π΄Π° Π²ΡΠ΅ ΠΎΡΡΠ°Π»ΡΠ½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΠΠΠ Π½Π΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ Π΄ΠΎΠ±ΠΈΡΡΡΡ Π°Π΄ΠΊΠ΅Π²Π°ΡΠ½ΠΎΠΉ ΠΎΠΊΡΠΈΠ³Π΅Π½Π°ΡΠΈΠΈ
EVALUATION OF EXPRESSION OF 4 MIRNAS IN CYTOLOGICAL SAMPLES AS AN ADDITIONAL METHOD OF CERVICAL CANCER DIAGNOSIS
Introduction. Cervical cancer is the 4th most common cancer among women. The main screening method for cervical cancer is cytological examination of the cervical epithelium. This method allows to evaluate the level of cervical dysplasia (malignant potential) but it has several limitations and flaws. Development and implementation of new methods of molecular and genetic analysis in clinical practice can increase informational value of the traditional cytological examination and therefore objectivity in choosing treatment options.Objective is to develop and verify a new method of differential diagnosis of severe intraepithelial dysplasia and invasive cervical cancer.Materials and methods. The method is based on analysis of small non-coding RNA molecules (miRNAs) extracted from the material of traditional Pap smears. Based on literature search, 18 βmarkerβ microRNA molecules were chosen and their expression levels were estimated in 166 samples of Pap smears from cervical canals with different cytological diagnoses. The analysis was performed using reverse transcription polymerase chain reaction.Results. Estimation of ratios between expression levels of miRNA pairs: 126/375; 20Π°/375; 126/145 allows to differentiate with high confidence borderline states of severe intraepithelial dysplasia and invasive cervical carcinoma (coefficients of quantitative interpretation of the error curve were 0.8, 0.75, 0.72, respectively).Conclusions. Analysis of miRNAs in Pap smear samples is a promising additional method of cervical cancer diagnosis. The method is objective and can be proposed as a supporting technique in cases when cytological examination doesnβt allow to differentiate between borderline pathological states of the cervical epithelium. Implementation of the method in clinical practice requires methodological optimization and additional validation using more clinical material
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