61 research outputs found
An expression analysis of markers of radiation-induced skin fibrosis and angiogenesis in wound healing disorders of the head and neck
Full text linkQuantitative proteomics reveals altered expression of extracellular matrix related proteins of human primary dermal fibroblasts in response to sulfated hyaluronan and collagen applied as artificial extracellular matrix
Full text linkA CCAAT DNA binding factor consisting of two different components that are both required for DNA binding.
No full textA CCAAT-binding activity present in nuclear extracts of rat liver and NIH 3T3 fibroblasts was purified using, as assay, DNA binding to a segment of the mouse alpha 2(I) collagen promoter. The activity consists of two components, designated factors A and B, which are separated by ion exchange chromatography on either Mono Q or Mono S columns. Factor A is heat-sensitive, whereas factor B is heat-resistant. Both factors are required for DNA binding and both are present in the DNA protein complex. The A + B complex was extensively purified by heparin-agarose and sequence-specific affinity chromatography. The Mr of factor A is 39,000, whereas the Mr of factor B is 41,000 as determined by renaturation of a highly purified preparation after sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Competition experiments indicate that this CCAAT-binding complex has a DNA sequence specificity that is different from those of other CCAAT-binding proteins
The transcription of human α1(I) procollagen gene (COL1A1) is suppressed by tumour necrosis factor-α through proximal short promoter elements: evidence for suppression mechanisms mediated by two nuclear-factorbinding sites
No full textNovel compound heterozygous nonsense and missense ABCA12 mutations lead to non-bullous congenital ichthyosiform erythroderma.
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AUTOSOMAL DOMINANT PALMOPLANTAR HYPERKERATOSIS AND SENSORINEURAL DEAFNESS IN 3 GENERATIONS
No full textA family is presented with autosomal dominant progressive palmoplantar hyperkeratosis, which is invariably associated with a slowly progressive, bilateral, high frequency, sensorineural hearing loss. The family show no other ectodermal abnormality. The differential diagnosis and possible mechanisms are discussed. This family appears to represent a unique variant in the hyperkeratosis-deafness association
A 45-year-old Woman with Ehlers-Danlos Syndrome Caused by Dermatan 4-O-sulfotransferase-1 Deficiency: Implications for Early Ageing
No full textRegulation of matrix metalloproteinase (MMP) expression in cutis laxa fibroblasts: upregulation of MMP‐1, MMP‐3 and MMP‐9 genes but not of the MMP‐2 gene
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