High resolution satellite imagery orientation accuracy assessment by leave-one-out method: accuracy index selection and accuracy uncertainty

The Leave-one-out cross-validation (LOOCV) was recently applied to the evaluation of High Resolution Satellite Imagery orientation accuracy and it has proven to be an effective method alternative with respect to the most common Hold-out-validation (HOV), in which ground points are split into two sets, Ground Control Points used for the orientation model estimation and Check Points used for the model accuracy assessment. On the contrary, the LOOCV applied to HRSI implies the iterative application of the orientationmodel using all the known ground points as GCPs except one, different in each iteration, used as a CP. In every iteration the residual between imagery derived coordinates with respect to CP coordinates (prediction error of the model on CP coordinates) is calculated; the overall spatial accuracy achievable from the oriented image may be estimated by computing the usual RMSE or, better, a robust accuracy index like the mAD (median Absolute Deviation) of prediction errors on all the iterations. In this way it is possible to overcome some drawbacks of the HOV: LOOCVis a reliable and robustmethod, not dependent on a particular set of CPs and on possible outliers, and it allows us to use each known ground point both as a GCP and as a CP, capitalising all the available ground information. This is a crucial problem in current situations, when the number of GCPs to be collected must be reduced as much as possible for obvious budget problems. The fundamentalmatter to deal with was to assess howwell LOOCVindexes (mADand RMSE) are able to represent the overall accuracy, that is howmuch they are stable and close to the corresponding HOV RMSE assumed as reference. Anyway, in the first tests the indexes comparison was performed in a qualitative way, neglecting their uncertainty. In this work the analysis has been refined on the basis of Monte Carlo simulations, starting from the actual accuracy of ground points and images coordinates, estimating the desired accuracy indexes (e.g. mAD and RMSE) in several trials, computing their uncertainty (standard deviation) and accounting for them in the comparison. Tests were performed on a QuickBird Basic image implementing an ad hoc procedure within the SISAR software developed by the Geodesy and Geomatics Team at the Sapienza University of Rome. The LOOCV method with accuracy evaluated by mAD seemed promising and useful for practical case

TTF-1/p63-positive poorly differentiated NSCLC: A histogenetic hypothesis from the basal reserve cell of the terminal respiratory unit

TTF-1 is expressed in the alveolar epithelium and in the basal cells of distal terminal bronchioles. It is considered the most sensitive and specific marker to define the adenocarcinoma arising from the terminal respiratory unit (TRU). TTF-1, CK7, CK5/6, p63 and p40 are useful for typifying the majority of non-small-cell lung cancers, with TTF and CK7 being typically expressed in adenocarcinomas and the latter three being expressed in squamous cell carcinoma. As tumors with coexpression of both TTF-1 and p63 in the same cells are rare, we describe different cases that coexpress them, suggesting a histogenetic hypothesis of their origin. We report 10 cases of poorly differentiated non-small-cell lung carcinoma (PD-NSCLC). Immunohistochemistry was performed by using TTF-1, p63, p40 (∆Np63), CK5/6 and CK7. EGFR and BRAF gene mutational analysis was performed by using real-time PCR. All the cases showed coexpression of p63 and TTF-1. Six of them showing CK7+ and CK5/6− immunostaining were diagnosed as “TTF-1+ p63+ adenocarcinoma”. The other cases of PD-NSCLC, despite the positivity for CK5/6, were diagnosed as “adenocarcinoma, solid variant”, in keeping with the presence of TTF-1 expression and p40 negativity. A “wild type” genotype of EGFR was evidenced in all cases. TTF1 stained positively the alveolar epithelium and the basal reserve cells of TRU, with the latter also being positive for p63. The coexpression of p63 and TTF-1 could suggest the origin from the basal reserve cells of TRU and represent the capability to differentiate towards different histogenetic lines. More aggressive clinical and morphological features could characterize these “basal-type tumors” like those in the better known “basal-like” cancer of the breast

Control of near-infrared supercontinuum bandwidth by adjusting pump pulse duration

We experimentally and numerically investigated the impact of input pump pulse duration on the near-infrared bandwidth of supercontinuum generation in a photonic crystal fiber. We continuously stretched the temporal duration of the input pump laser (centered at 1030 nm) pulses from 500 fs up to 10 ps, while keeping fixed the pump peak power. We observed that the long-wavelength edge of the supercontinuum spectrum is increased by 200 nm as the pump pulse duration grows from 500 fs to 10 ps. We provide a quantitative fit of the experimental results by means of numerical simulations. Moreover, we have explained the observed spectral broadening enhancement induced by pump pulse energy by developing an approximate yet fully analytical model for soliton energy exchange through a series of collisions in the presence of stimulated Raman scattering

First considerations on post processing kinematic GNSS data during a geophysical oceanographic cruise

Differential GNSS positioning on vessels is of considerable interest in various fields of application as navigation aids, precision positioning for geophysical surveys or sampling purposes especially when high resolution bathymetric surveys are conducted. However ship positioning must be considered a kinematic survey with all the associated problems. The possibility of using high-precision differential GNSS receivers in navigation is of increasing interest, also due to the very recent availability of low-cost differential receivers that may soon replace classic navigation ones based on the less accurate point positioning technique. The availability of greater plano-altimetric accuracy, however, requires an increasingly better understanding of planimetric and altimetric reference systems. In particular, the results allow preliminary considerations on the congruence between terrestrial reference systems (which the GNSS survey can easily refer to) and marine reference systems (connected to National Tidegauge Network). In spite of the fluctuations due to the physiological continuous variation of the ship's attitude, GNSS plot faithfully followed the trend of the tidal variations and highlighted the shifts between GNSS plot and the tide gauges due to the different materialization of the relative reference systems

Common faith or parting ways? A time varying parameters factor analysis of euro-area inflation

We analyze the interaction among the common and country specific components for the inflation rates in twelve euro area countries through a factor model with time varying parameters. The variation of the model parameters is driven by the score of the predictive likelihood, so that, conditionally on past data, the model is Gaussian and the likelihood function can be evaluated using the Kalman filter. The empirical analysis uncovers significant variation over time in the model parameters. We find that, over an extended time period, inflation persistence has fallen over time and the importance of common shocks has increased relatively to the idiosyncratic disturbances. According to the model, the fall in inflation observed since the sovereign debt crisis, is broadly a common phenomenon, since no significant cross country inflation differentials have emerged. Stressed countries, however, have been hit by unusually large shocks

Quality Characteristics of Wholemeal Flour and Bread from Durum Wheat (Triticum turgidum L subsp. durum Desf.) after Field Treatment with Plant Water Extracts

The use of selected plant water extracts to control pests and weeds is gaining growing attention in organic and sustainable agriculture, but the effects that such extracts may exert on the quality aspects of durum wheat are still unexplored. In 2014, 5 plant water extracts (Artemisia arborescens, Euphorbia characias, Rhus coriaria, Thymus vulgaris, Lantana camara) were prepared and distributed on durum wheat cv Valbelice to evaluate their potential herbicidal effects. After crop harvesting, the major physicochemical and technological parameters of wholemeal flours obtained from each treatment were measured and compared with those from chemical weeding and untreated controls. A baking test was also performed to evaluate the breadmaking quality. In wholemeal flours obtained after the treatment with plant extracts protein and dry gluten content were higher than in control and chemical weeding. Wholemeal flours obtained after chemical weeding reached the highest Mixograph parameters, and that from durum wheat treated with R. coriaria extract demonstrated a very high α-amylase activity. We concluded that the treatments with plant water extracts may influence many quality traits of durum wheat. This occurrence must be taken into account in overall decisions concerning the use of plant extracts in pest and weed management practice

Neurological Consequences of Systemic Inflammation in the Premature Neonate

Despite substantial progress in neonatal care over the past two decades leading to improved survival of extremely premature infants, extreme prematurity continues to be associated with long term neurodevelopmental impairments. Cerebral white matter injury is the predominant form of insult in preterm brain leading to adverse neurological consequences. Such brain injury pattern and unfavorable neurologic sequelae is commonly encountered in premature infants exposed to systemic inflammatory states such as clinical or culture proven sepsis with or without evidence of meningitis, prolonged mechanical ventilation, bronchopulmonary dysplasia, necrotizing enterocolitis and chorioamnionitis. Underlying mechanisms may include cytokine mediated processes without direct entry of pathogens into the brain, developmental differences in immune response and complex neurovascular barrier system that play a critical role in regulating the cerebral response to various systemic inflammatory insults in premature infants. Understanding of these pathologic mechanisms and clinical correlates of such injury based on serum biomarkers or brain imaging findings on magnetic resonance imaging will pave way for future research and translational therapeutic opportunities for the developing brain