L'ictère est-il une cause d'erreur dans l'interprétation du CA 19-9 sérique?

Serum CA 19-9 has been proposed as a tumour marker for pancreatic cancer (PC). However, false positive results are seen in sera of patients with benign jaundice. The CA 19-9 assay was performed by a solid state radioimmunoassay in 86 icteric patients (total bilirubin greater than 2 mg/dl). 24/86 had PC (12 men, 12 women, mean age 74 years) and 62/86 had benign jaundice (29 men, 33 women, mean age 56 years; cirrhosis: n = 20, angiocholitis: n = 21, hepatitis: n = 21). At a cut-off level of 60 U./ml, for detecting icteric PC, sensitivity was 83%, and specificity was 79%. At 120 U./ml, sensitivity was 79%, but specificity was increased to 92%. We conclude that 21% of patients with benign jaundice had a CA 19-9 level greater than 60 U./ml, and using a CA 19-9 level of 120 U./ml, the specificity of the test to detect icteric PC was increased, with little decrease in the sensitivity

The utility of publicly-available satellite imagery for investigating looting of archaeological sites in Jordan

International response to the problem of looting of archaeological sites has been hampered by the difficulty of quantifying the damage done. The scarcity of reliable information negatively impacts professional and public policy making, rendering consensus about the scale of the problem and the effectiveness of policy responses difficult to achieve. We report here on the use of publicly-available satellite imagery for quantifying the damage caused by looting of archaeological sites in Jordan. The ease of use and affordability of imagery such as that provided by Google Earth make the identification, quantification, and monitoring of archaeological site looting possible at a level previously unimagined. Our findings about looting at archaeological sites in Jordan shed light on the potential for a broader application of the method