Complex biochemical characteristics of <i>Coriandrum sativum</i> L.

Background.  Coriandrum sativum L. is a valuable vegetable crop with early maturity and high nutritional benefits. Green biomass of coriander is rich in vitamins, especially ascorbic acid and carotene. The feasibility of using coriander as a natural food additive is due to its high antioxidant activity. The aim of this research was to study the biochemical composition of the green biomass in the accessions of C. sativum from the VIR global collection and identify promising accessions for use in breeding for quality.Materials and methods. The green biomass of  67 coriander accessions from different countries maintained in the VIR collection served as the research material. The study was carried out according to the guidelines developed by VIR.Results. As a result of the study, the feasibility of using C. sativum as a source of bioactive compounds was theoretically justified and experimentally confirmed, thus attesting to the prospects of coriander accessions from the VIR collection for quality-targeted breeding programs. New data were obtained on the biochemical composition of coriander green biomass. A factor determining such biochemical composition is the genotypic features of coriander associated with its origin. Biochemical parameters in coriander varied significantly depending on the origin of an accession. The highest variability was observed in the content of carotenes (CV 41%). The effect of an accession’s precocity was not confirmed. Sources for individual quality indicators were highlighted.Conclusion. Accessions with an optimal component composition for a balanced human diet were identified and recommended for quality-oriented breeding, including the development of cultivars for health-friendly, curative and preventive nutrition. The selected accessions are of interest as source material for breeding programs and practical utilization

NEW POSSIBILITIES OF STATIN THERAPY IN ARTERIAL HYPERTENSION

Background. Effects of statins on cardiovascular end points are well-known. To study the impact of statins on structural and functional heart remodeling in patients with arterial hypertension (HT) seemsto be topical.Aim. To study the effect of statins on cardiac remodeling in patients with HT.Materials and methods. 120 patients with HT of 1 degree were included into the study: 56 men, 64 women, aged 52.4±10.23. Patients were randomized into 4 treatment groups: Group A1 (angiotensin converting enzyme (ACE) inhibitors + diet), group A2 (ACE inhibitor + fluvastatin), group B1 (angiotensin II receptor antagonist (ARA II) + diet), group B2 (ARAII + fluvastatin). Transthoracic echocardiography with calculation of standard left ventricle (LV) remodeling indices was performed.Results. The most important prognostic markers of LV remodeling were revealed. They were a basis for definition of 3 types of early LV remodeling: type 1 — compensated, type 2 — adaptive, 3 type — maladaptive. After 6 months of treatment a number of patients in group A1 with type 2 and type 3 of LV remodeling reduced less (2%, p=0.02 and 4%, p=0.04, respectively) than this in group A2 (14%, p=0.04) and 4%, p=0.04, respectively). A number of patients with type 1 (compensated) of LV remodeling increased by 18% (p&lt;0.001) in group A2, and by 6%, (p=0.03) in group A1. After the treatment a number of patients with type 3 and type 2 of LV remodeling decreased (p&lt;0.001 and p=0.04, respectively) in groups B1 and B2 while a number of patients with type 1 of LV remodeling increased (p&lt;0,001). A number of patients with type 1 of LV remodeling increased and this with type 3 of LV remodeling decreased in group B2 more prominently in comparison with group A2 (p=0.03; p=0.01, respectively).Conclusion. Statins in patients with HT have cardioprotective effect that does not depend on basic antihypertensive therapy and total cholesterol level. In these patients combination of statins with ARA II has better cardioprotective effect than this with ACE inhibitors

Clinical results of the long-term use of ticagrelor in patients with 2 type diabetes for primary prevention of acute cardiovascular events

The article compares the clinical effects of prolonged use of Ticagrelor in patients with type 2 diabetes mellitus for the primary prevention of acute cardiovascular events in comparison with patients receiving placebo.В статье сравниваются клинические эффекты длительного применения препарата Тикагрелор у больных сахарным диабетом 2 типа для первичной профилактики острых сердечно-сосудистых событий в сравнении с пациентами, получающими плацебо

ВИЗУАЛЬНОЕ ТЕСТ-ОПРЕДЕЛЕНИЕ Pb(II) С ИСПОЛЬЗОВАНИЕМ ИНДИКАТОРНОЙ ЖЕЛАТИНОВОЙ ПЛЕНКИ

A hardened gelatin gel deposited on a transparent polymeric matrix is of interest for the development of highly sensitive methods which combine concentration and subsequent determination of the analyte in the solid phase.For visual test for determination of lead (II) commercial photographic film with immobilized indikator bromopyrogallol red is proposed to use. The optimal conditions for the immobilization of the reagent and the metal complex in the film are determined. The composition and stability of the indicator reaction products are evaluated in solution and heterogeneous water / gelatin film. On the basis of  these studies the technique of visual test determination of lead, based on the formation of complex compounds of Pb (II) c bromopyrogallol red in the medium hardened gelatin gel are found. Metrological characteristics of the proposed method of visual test determination of Pb (II) with the use of the indicator film are developed. Correctness of the methodology for determination of lead was tested on model solutions and real objects.Keywords: bromopyrogallol red, lead (II), the indicator gelatin film, immobilization, visual colorimetry.(Russian)DOI: http://dx.doi.org/10.15826/analitika.2014.18.3.009 P.V Anisimovich1,  Z.A Temerdashev1,  T.B Pochinok1, E.A. Reshetniak2, T.S. Smolenskaya1,  O.Iu. Lomakina1  1Federal state budget educational institution of higher professional education "Kuban State University", Krasnodar, Russian Federation2V.N. Karazin Kharkiv National University, Kharkiv, UkraineСреди прозрачных полимерных сорбентов, используемых  для концентрирования и последующего определения аналита непосредственно в твердой фазе, особый интерес представляет желатиновый отвержденный гель, нанесенный на прозрачную полимерную матрицу.Для визуально-тестового определения свинца(II) предложено использовать коммерческую фотопленку с иммобилизованным металлоиндикатором бромпирогаллоловым красным. Найдены оптимальные условия иммобилизации реагента и металлокомплекса в пленке. Установлен состав и оценена устойчивость продуктов индикаторной реакции в растворе и в гетерогенной системе вода/желатиновая пленка. На основе проведенных исследований разработана методика визуального тест-определения свинца, основанная на образовании комплексного соединения Pb(II) c  бромпирогаллоловым красным в среде  отвержденного желатинового геля. Оценены метрологические характеристики предложенной методики визуального тест-определения Pb(II) с использованием индикаторной пленки: интервал ненадежности обнаружения Pb(II) (1.9-3.7 мкМ), предел обнаружения (3.2 мкМ) и предел определения (3.9 мкМ) металла по цветовой шкале. Правильность определения в модельных растворах и реальных объектах доказана методом «введено-найдено» и независимым методом.Ключевые слова: бромпирогаллоловый красный, свинец(II), индикаторная желатиновая пленка, иммобилизация, визуальная колориметрия.DOI: http://dx.doi.org/10.15826/analitika.2014.18.3.009

Nodular polyarteritis

Polyarteritis nodosa is a disease with a long history, but there are still many gaps in its study. The work is devoted to the comparison of the classic variant of polyarteritis nodosa and modern ideas about this disease, also to the generalization of literary data from Russian-speaking and foreign sources about pathogenesis, clinical picture, diagnosis and treatment of polyarteritis nodosa.Узелковый полиартериит-это заболевание с длинной историей, однако в его изучении всё ещё много пробелов. Работа посвящена сравнению классического варианта узелкового полиартериита и современных представлений о данном заболевании, а также обобщению литературных данных из русскоязычных и иностранных источников о патогенезе, клинике, диагностике и лечении узелкового полиартериит

Influence of a new fiber (pema fibrate) on the indicators of lipid spectrum and carbohydrate metabolism in patients with type 2 type and coronary atherosclerosis

The article deals with the diagnosis of atherosclerosis in patients with type 2 diabetes. The pharmacodynamic effect of the new fibrate (pemafibrate) is described. A study was made of the effect of pemafibrate on lipid profile (total cholesterol, TG, HDL, non HDL) and carbohydrate metabolism (glucose) in patients on the placebo-controlled study PROMINENT.В статье рассмотрены вопросы диагноза атеросклероз у больных СД 2 типа. Описан фармакодинамический эффект нового фибрата (пемафибрат). Проведено исследование влияния пемафибрата на показатели липидного спектра (ОХС, ТГ, HDL, неHDL) и углеводного обмена (глюкоза) у пациентов, находящихся на плацебо-контролируемом исследовании PROMINENT

Metabolomic profiles of <i>Ribes nigrum</i> L. and <i>Lonicera caerulea</i> L. from the collection of the N.I. Vavilov Institute in the setting of Northwest Russia

Recently, the trend of using fruit and berry crops as ingredients for functional and dietary nutrition, the development and implementation of flavors, pigments, new medicines and dietary supplements has been actualized. Because the direction of use depends on the biochemical properties of fruits, which are determined not only by species and varietal characteristics, but also by reproduction conditions, the study of the biochemical composition of fruits grown in various regions of the world continues to be relevant. In this regard, the collection of N.I. Vavilov Institute (VIR), which has a wide diversity of fruit and berry crops, is of great interest for study. Ribes nigrum fruits have a balanced set of sugars, organic acids, essential oils, microelements, a high content of vitamins, anthocyanins, pectins. Lonicera caerulea fruits are characterized by high values of phenolic substances: bioflavonoids, hydroxycinnamic acids, flavonols, polyphenols, anthocyanins, as well as vitamins, carotenoids, iridoid glycosides and other natural antioxidants. The investigation of L. caerulea and R. nigrum fruit’s accessions from the VIR collection using gas-liquid chromatography with mass spectrometry allows us to obtain new information about the biochemical characteristics of fruits, to identify L. caerulea and R. nigrum varieties with optimal economically valuable characteristics, to determine the specificity of L. caerulea and R. nigrum metabolomic spectra in the setting of Northwest Russia. As a result of the analysis, typical compounds of the metabolomic profile of each culture were identified. Organic acids, phenol-containing compounds and polyols prevailed in L. caerulea, while mono- and oligosaccharides, in R. nigrum. The qualitative composition of the black currant varieties ‘Malen’kii Printz’, ‘Dobriyi Dzhinn’, ‘Tisel’, ‘Orlovskii Val’s’, and blue honeysuckle ‘S 322-4’, ‘Malvina’, ‘Leningradsky Velikan’ was optimal for food consumption; the varieties of blue honeysuckle ‘Bazhovskaya’ and black currant ‘Aleander’ had a good representation of biologically active compounds, which makes samples attractive as raw materials for the production of biologically active additives, including with the use of microorganisms’ cultures

Manifestations of post-covid syndrome in patients with a history of cardiovascular pathology

The aim of this study - to evaluate new symptoms and the presence of worsening of major cardiovascular diseases in patients who have had COVID-19 and have concomitant cardiovascular diseases after discharge, after 3 and 6 months.Цель исследования - оценить новые симптомы и наличие ухудшений основных ССЗ у пациентов, переболевших COVID-19, имеющих сопутствующую ССП, после выписки, через 3 и 6 месяце

Cognitive indicators in patients with high SSR without type 2 DM on the background of Semaglutide treatment

The article reviewed the influence of the drug Semaglutide on reducing overweight in patients with high SSR without type 2 DM. The relationship between reducing overweight, improving cognitive indicators has also been investigated and the quality of life.В статье рассмотрено влияние препарата Семаглутид на снижение избыточной массы тела у пациентов с высоким ССР без СД 2 типа. Была также исследована связь между снижением избыточного веса, улучшением когнитивных показателей и качества жизни

Effect of regular statin intake on the development of cardiovascular events in the acute period of Covid-19 and within three months after discharge from the infectious diseases hospital. Part 1. Analysis of patients with fatal outcome during hospitalization

The aim of the study was to evaluate the relationship of regular statin intake with death and the development of new cardiovascular events in patients with cardiovascular pathology in the acute period of COVID-19.Цель исследования – оценить взаимосвязь регулярного приема статинов с летальным исходом и развитием новых сердечно-сосудистых событий у пациентов, имеющих сердечно-сосудистую патологию в острый период COVID-19