238,174 research outputs found
Theory of the Jamming Transition at Finite Temperature
A theory for the microscopic structure and the vibrational properties of soft
sphere glass at finite temperature is presented. With an effective potential,
derived here, the phase diagram and vibrational properties are worked out
around the Maxwell critical point at zero temperature and pressure .
Variational arguments and effective medium theory identically predict a
non-trivial temperature scale with
such that low-energy vibrational properties are hard-sphere like for , and zero-temperature soft-sphere like otherwise. However, due to
crossovers in the equation of state relating , , and the packing fraction
, these two regimes lead to four regions where scaling behaviors differ
when expressed in terms of and . Scaling predictions are presented
for the mean-squared displacement, characteristic frequency, shear modulus, and
characteristic elastic length in all regions of the phase diagram.Comment: 8 pages + 3 pages S
Supercritical super-Brownian motion with a general branching mechanism and travelling waves
We consider the classical problem of existence, uniqueness and asymptotics of
monotone solutions to the travelling wave equation associated to the parabolic
semi-group equation of a super-Brownian motion with a general branching
mechanism. Whilst we are strongly guided by the probabilistic reasoning of
Kyprianou (2004) for branching Brownian motion, the current paper offers a
number of new insights. Our analysis incorporates the role of Seneta-Heyde
norming which, in the current setting, draws on classical work of Grey (1974).
We give a pathwise explanation of Evans' immortal particle picture (the spine
decomposition) which uses the Dynkin-Kuznetsov N-measure as a key ingredient.
Moreover, in the spirit of Neveu's stopping lines we make repeated use of
Dynkin's exit measures. Additional complications arise from the general nature
of the branching mechanism. As a consequence of the analysis we also offer an
exact X(log X)^2 moment dichotomy for the almost sure convergence of the
so-called derivative martingale at its critical parameter to a non-trivial
limit. This differs to the case of branching Brownian motion and branching
random walk where a moment `gap' appears in the necessary and sufficient
conditions.Comment: 34 page
Packet equalisation in PONs using adjustable gain-clamped semiconductor optical amplifiers (AGC-SOA)
The past ten years have witnessed a dramatic growth in the delivery of high bandwidth services through Passive Optical Networks (PONs), directly to the home or to the kerb. The bursty nature of upstream traffic in a PON (from the user to Optical Network Unit, ONU) combined with a wide dynamic range of signal strength (-15dB to -28dB the difference between a very close Optical Network Terminal (ONT) with a small split ratio and a distant ONT with a high split ratio), places severe demands on the burst mode receiver at the ONU. We report here on an adjustable gain-clamped semiconductor optical amplifier (AGC-SOA) designed to maximize the output saturated power while adjusting gain to regulate the power differences between packets without loss of linearity. This device is shown to be able to modulate gain at rates that are compatible with packet to packet equalisation. Through theoretical analysis coupled with experimental verification, this paper demonstrates for the first time that this is entirely feasible
Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression.
BackgroundNovel therapies are needed for children with high-risk and relapsed neuroblastoma. We hypothesized that MAPK/ERK kinase (MEK) inhibition with the novel MEK1/2 inhibitor binimetinib would be effective in neuroblastoma preclinical models.MethodsLevels of total and phosphorylated MEK and extracellular signal-regulated kinase (ERK) were examined in primary neuroblastoma tumor samples and in neuroblastoma cell lines by Western blot. A panel of established neuroblastoma tumor cell lines was treated with increasing concentrations of binimetinib, and their viability was determined using MTT assays. Western blot analyses were performed to examine changes in total and phosphorylated MEK and ERK and to measure apoptosis in neuroblastoma tumor cells after binimetinib treatment. NF1 protein levels in neuroblastoma cell lines were determined using Western blot assays. Gene expression of NF1 and MEK1 was examined in relationship to neuroblastoma patient outcomes.ResultsBoth primary neuroblastoma tumor samples and cell lines showed detectable levels of total and phosphorylated MEK and ERK. IC50 values for cells sensitive to binimetinib ranged from 8 nM to 1.16 μM, while resistant cells did not demonstrate any significant reduction in cell viability with doses exceeding 15 μM. Sensitive cells showed higher endogenous expression of phosphorylated MEK and ERK. Gene expression of NF1, but not MEK1, correlated with patient outcomes in neuroblastoma, and NF1 protein expression also correlated with responses to binimetinib.ConclusionsNeuroblastoma tumor cells show a range of sensitivities to the novel MEK inhibitor binimetinib. In response to binimetinib, sensitive cells demonstrated complete loss of phosphorylated ERK, while resistant cells demonstrated either incomplete loss of ERK phosphorylation or minimal effects on MEK phosphorylation, suggesting alternative mechanisms of resistance. NF1 protein expression correlated with responses to binimetinib, supporting the use of NF1 as a biomarker to identify patients that may respond to MEK inhibition. MEK inhibition therefore represents a potential new therapeutic strategy for neuroblastoma
Thermal barrier coating life prediction model development
Thermal barrier coatings (TBCs) for turbine airfoils in high-performance engines represent an advanced materials technology with both performance and durability benefits. The foremost TBC benefit is the reduction of heat transferred into air-cooled components, which yields performance and durability benefits. This program focuses on predicting the lives of two types of strain-tolerant and oxidation-resistant TBC systems that are produced by commercial coating suppliers to the gas turbine industry. The plasma-sprayed TBC system, composed of a low-pressure plasma-spray (LPPS) or an argon shrouded plasma-spray (ASPS) applied oxidation resistant NiCrAlY (or CoNiCrAlY) bond coating and an air-plasma-sprayed yttria (8 percent) partially stabilized zirconia insulative layer, is applied by Chromalloy, Klock, and Union Carbide. The second type of TBC is applied by the electron beam-physical vapor deposition (EB-PVD) process by Temescal
Control of dissipation in superconducting films by magnetic stray fields
Hybrid superconducting/magnetic nanostructures on Si substrates have been
built with identical physical dimensions but different magnetic configurations.
By constructing arrays based on Co-dots with in-plane, out-of-plane, and vortex
state magnetic configurations, the stray fields are systematically tuned.
Dissipation in the mixed state of superconductors can be decreased (increased)
by several orders of magnitude by decreasing (increasing) the stray magnetic
fields. Furthermore, ordering of the stray fields over the entire array helps
to suppress dissipation and enhance commensurability effects increasing the
number of dissipation minima.Comment: 16 pages including 4 figures; accepted in Applied Physics Letter
Dielectric nonlinearity of relaxor ferroelectric ceramics at low ac drives
Dielectric nonlinear response of
(PbMgNbO)(PbTiO) (0.9PMN-0.1PT) relaxor
ceramics was investigated under different ac drive voltages. It was observed
that: (i) the dielectric permittivity is independent on ac field amplitude at
high temperatures; (ii) with increasing ac drive, the permittivity maximum
increases, and the temperature of the maximum shifts to lower temperature;
(iii) the nonlinear effect is weakened when the measurement frequency
increases. The influences of increasing ac drive were found to be similar to
that of decreasing frequency. It is believed that the dielectric nonlinearities
of relaxors at low drives can be explained by the phase transition theory of
ergodic space shrinking in succession. A Monte Carlo simulation was performed
on the flips of micro polarizations at low ac drives to verify the theory.Comment: Submitted to J. Phys.: Cond. Matte
Food Safety Incidents, Collateral Damage and Trade Policy Responses: China-Canada Agri-Food Trade
As markets become globalized, food safety policy and international trade policy are increasingly intertwined. Globalization also means that food safety incidents are widely reported internationally. One result is that food safety incidents can negatively impact products where no food safety issue exists as consumers lose trust in both foreign and domestic food safety institutions. While the policy framework for dealing with directly effected imported foods is well understood, how to deal with the market failure associated with indirectly affected products within the existing trade policy rules has not been explored. Using the example of China’s 2007 problems with a spate of products safety incidents, a theoretical framework is developed and the response of both the Chinese and Canadian governments analyzed. A cooperative approach to the issues appears to have a number of advantages and does not contravene trade policy commitments.Canada, China, cooperation, food safety, market failure, trade policy, Agricultural and Food Policy, International Development, International Relations/Trade,
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