Relationship of Staphylococcal Aureus Colonization with Severity of Psoriasis Vulgaris Disease According to PASI Score

Background & Aims: colonized by staphylococcus aureus were reported in more than 50% of psoriatic lesions. Due to role of epidermal barrier dysfunction on colonization and on the other hands staphylococcal super antigen effect on flare up of disease, this study was conducted to evaluate relationship of staphylococcal aureus colonization with severity of psoriasis disease according to PASI Score. Materials and Methods: In a descriptive analytic study, 42 psoriasis new cases that had not received any topical or systematic medication for disease underwent study. Necessary demographic and clinical data were collected and PASI score for severity of disease according to erythema, infiltration, desquamation and area was calculated. Skin lesions samples were taken by a swab and sent to the laboratory for culture. Data analysis was done by SPSS ver. 13 using T test. Results: lesions of 19 cases (45.2%) were colonized with staphylococcal aureus. Mean of PASI score in positive culture group was 16.07± 3.6 in comparison to negative culture group as 12.43± 3.67 that this difference was significant (P=0.001). There was not any significant difference between duration of disease between positive and negative culture groups (7.11±4.98vs. 6.39±5.25 years). Conclusion: This study showed a significant difference between PASI Score among negative and positive culture groups that this difference may be due to the staphylococcal super antigen effect on psoriasis lesions

Comparison of Serum Vit D Level Between Psoriasis Patients and Normal Population

Introduction: Psoriasis is a common inflammatory skin disorder with humeral and cellular immune system involvement. On the other hands، Vitamin D has important immunomodulatory effects and its relations with many autoimmune diseases were shown. The relation between Serum Vit D Level and Psoriasis disease remained controversial issue that this study was done to show this relationship. Methods and Materials: In this comparative cross sectional study، 30 psoriatic patients who attended to Razi dermatology clinic in Rasht، by sequential sampling underwent study as case group. 30 healthy people from hospital at the same age، gender and skin-colored also were selected as control group. Inclusion criteria were patients and people without Ca or Vit D supplements usage or underground diseases in relation to hypovitaminosis D. Demographical data were gathered by interviewing and then blood samples from all participants were sent for analysis of serum Ca، P، Vit D and parathormone level. Data analysis was done by SPSS ver. 18 using T-test and Chi 2 test. Result: Mean and SD serum level of Vit D in case and control groups were 25.8± 12.6 ng/ mL and  23.7± 8.9 ng/ mL، respectively (ρ>0.05). Out of all، 24 participants (40%) suffered from Vit D Deficiency and 20 people (33.3%) from Vit D insufficiency ، only 26.7% study subjects had acceptable serum Vit D level. There were not any significant difference between Vit D deficiency rates and other measured biochemical indices in two groups (36.7% vs. 43.3%). Conclusion: This study showed high level of Vit D deficiency in both psoriatic and normal people that must be notice