Two dimensional electron gas driven by strong alternating electric field

2D Fermi liquid driven by uniform alternating electric field at zero temperature may remain in quantum coherent non-equilibrium state. We develop a quasistatic approximation for strong and slow ac-fields and solve the problem of driven disordered 2D electron gas in high non-overlapping Landau levels. The broadening of Landau level has the Lorentz form and is inversely proportional to the amplitude of the ac-field. In the absence of electron-phonon interaction the electron distribution function is constant within the last Landau level and the diagonal dc-conductivity is zero. For weak electron-phonon interaction the dc-conductivity is anisotropic. A kinetic transition from the phonon cooling to the phonon heating is predicted.Comment: 8 pages, 1 figure REVTE

Saquinavir Loaded Acetalated Dextran Microconfetti – a Long Acting Protease Inhibitor Injectable

Since the adoption of highly active antiretroviral therapy, HIV disease progression has slowed across the world; however, patients are often required to take multiple medications daily of poorly bioavailable drugs via the oral route, leading to gastrointestinal irritation. Recently, long acting antiretroviral injectables that deliver drug for months at a time have moved into late phase clinical trials. Unfortunately, these solid phase crystal formulations have inherent drawbacks in potential dose dumping and a greater likelihood for burst release of drug compared to polymeric formulations

Multicomponent dense electron gas as a model of Si MOSFET

We solve two-dimensional model of $N$-component dense electron gas in the limit of large $N$ and in a range of the Coulomb interaction parameter: $N^{-3/2}\ll r_s\ll 1$. The quasiparticle interaction on the Fermi circle vanishes as 1/N. The ground state energy and the effective mass are found as series in powers of $r_s^{2/3}$. In the quantum Hall state on the lowest Landau level at integer filling: $1\ll\nu<N$, the charge activation energy gap and the exchange constant are found.Comment: 10 pages, 4 figure

Continuum limit, Galilean invariance, and solitons in the quantum equivalent of the noisy Burgers equation

A continuum limit of the non-Hermitian spin-1/2 chain, conjectured recently to belong to the universality class of the noisy Burgers or, equivalently, Kardar-Parisi-Zhang equation, is obtained and analyzed. The Galilean invariance of the Burgers equation is explicitly realized in the operator algebra. In the quasi-classical limit we find nonlinear soliton excitations exhibiting the $\omega\propto k^z$ dispersion relation with dynamical exponent $z=3/2$.Comment: 12 pages, latex, no figure

Giant Magnetoresistance Oscillations Induced by Microwave Radiation and a Zero-Resistance State in a 2D Electron System with a Moderate Mobility

The effect of a microwave field in the frequency range from 54 to 140 $\mathrm{GHz}$ on the magnetotransport in a GaAs quantum well with AlAs/GaAs superlattice barriers and with an electron mobility no higher than $10^6$ $\mathrm{cm^2/Vs}$ is investigated. In the given two-dimensional system under the effect of microwave radiation, giant resistance oscillations are observed with their positions in magnetic field being determined by the ratio of the radiation frequency to the cyclotron frequency. Earlier, such oscillations had only been observed in GaAs/AlGaAs heterostructures with much higher mobilities. When the samples under study are irradiated with a 140-$\mathrm{GHz}$ microwave field, the resistance corresponding to the main oscillation minimum, which occurs near the cyclotron resonance, appears to be close to zero. The results of the study suggest that a mobility value lower than $10^6$ $\mathrm{cm^2/Vs}$ does not prevent the formation of zero-resistance states in magnetic field in a two-dimensional system under the effect of microwave radiation.Comment: 4 pages, 2 figur

Development of an LC-MS Method for Measuring TNF in Human Vaginal Tissue

A sensitive, accurate, and precise liquid chromatography–mass spectrometry assay for the determination of tenofovir (TNF) in human vaginal tissue was developed and validated. After homogenization of the tissue, solid-phase extraction on Varian Bond Elut-C18 column was used for sample clean up. Chromatographic separation of TNF and the internal standard (tolbutamide) was achieved with a Varian Polaris 3C18-A reversed-phase analytical column (150 mm × 2 mm). A gradient method using 0.1% formic acid in water and 0.1% formic acid in acetonitrile was employed. Detection of TNF and tolbutamide was achieved by electrospray ionization mass spectrometry in the positive ion mode using 288.05 and 271.00 m/z, respectively. Linear TNF calibration curves were obtained between 1–1,000 ng/mL with a correlation coefficient (r2) greater than 0.999. Intra-and inter-day accuracy for TNF ranged from 89.7% and 109.4% and from 97.3% and 104.9%, and precision ranged from 1.3% and 10.9% and 2.6% and 9.0%, respectively. This is the first validated method developed to quantitate TNF in human tissues

Maternal-Fetal Pharmacokinetics and Dynamics of a Single Intrapartum Dose of Maraviroc in Rhesus Macaques

Single-dose nevirapine (NVP) is effective in reducing mother-to-child transmission (MTCT) of HIV; however, the subsequent development of drug resistance is problematic. The pharmacokinetic profile of the HIV entry inhibitor maraviroc after a single intrapartum dose in rhesus macaques was studied to determine whether maraviroc could serve as an alternative to NVP in a single-dose strategy. Four pregnant macaques received an oral dose of maraviroc 2 h before delivery, and both infant and maternal plasma maraviroc concentrations and CCR5 receptor occupancy on CD4+ lymphocytes were measured over time. Maximum plasma maraviroc concentrations were found at delivery (2-h-postintrapartum dose) in both the mothers and infants, with median concentrations of 974 ng/ml (range, 86 to 2,830 ng/ml) and 22 ng/ml (range, 4 to 99 ng/ml), respectively. Maraviroc was detected in the plasma of mothers up to 48 h after dosing but only as long as 3.5 h in the infants. The median fetal-maternal area under the concentration-time curve (AUC) ratio was 0.009 (range, 0.000 to 0.015). Maraviroc receptor occupancy data showed evidence of unprotected CCR5 receptors on CD4+ cells in the mothers 24 to 48 h after dosing. Extremely low CCR5 expression on CD4+ cells of newborn macaques prevented determination of receptor occupancy in the infants. In rhesus macaques, maraviroc was poorly transferred across the placenta and was quickly cleared from the infants’ blood. The low concentrations of fetal maraviroc and short pharmacokinetic profile in infants suggest that a single maternal intrapartum dose of maraviroc would not be effective in reducing the risk of MTCT of HIV

The Shapes of Flux Domains in the Intermediate State of Type-I Superconductors

In the intermediate state of a thin type-I superconductor magnetic flux penetrates in a disordered set of highly branched and fingered macroscopic domains. To understand these shapes, we study in detail a recently proposed "current-loop" (CL) model that models the intermediate state as a collection of tense current ribbons flowing along the superconducting-normal interfaces and subject to the constraint of global flux conservation. The validity of this model is tested through a detailed reanalysis of Landau's original conformal mapping treatment of the laminar state, in which the superconductor-normal interfaces are flared within the slab, and of a closely-related straight-lamina model. A simplified dynamical model is described that elucidates the nature of possible shape instabilities of flux stripes and stripe arrays, and numerical studies of the highly nonlinear regime of those instabilities demonstrate patterns like those seen experimentally. Of particular interest is the buckling instability commonly seen in the intermediate state. The free-boundary approach further allows for a calculation of the elastic properties of the laminar state, which closely resembles that of smectic liquid crystals. We suggest several new experiments to explore of flux domain shape instabilities, including an Eckhaus instability induced by changing the out-of-plane magnetic field, and an analog of the Helfrich-Hurault instability of smectics induced by an in-plane field.Comment: 23 pages, 22 bitmapped postscript figures, RevTex 3.0, submitted to Phys. Rev. B. Higher resolution figures may be obtained by contacting the author

Smecticlike phase for modulated XY spins in two dimensions

The row model for frustrated XY spins on a triangular lattice in 2D is used to study incommensurate{IC}) spiral and commensurate{C} antiferromagnetic (AF) phases, in the regime where a C-IC transition occurs. Using fluctuating boundary conditions and specific histogram techniques, a detailed Monte Carlo (MC) study reveals more structure in the phase diagram than found in previous MC simulations of the full parameter space. On the (C) side, equilibrium configurations consist of alternating stripes of spiral phases of opposite chirality separated by walls of the (C) phase. For this same parameter regime, thermodynamic quantities are computed analytically using the NSCHA, a generalization of the self consistent harmonic approximation appropriate for chiral systems. On the commensurate side of the (C)-(IC) boundary, NSCHA predicts an instability of the (C) phase. This suggests that the state is spatially inhomogeneous, consistent with the present MC result: it resembles the smectic-A phase of liquid crystals, and its existence implies that the Lifshitz point is at ${T=0}$ for modulated XY spins in 2D. The connection between frustrated XY systems and the vortex state of strong type II superconductors suggests that the smectic phase may correspond to a vortex liquid phase of superconducting layers.Comment: Single Postscript file containing 24 pages of text and 8 figures. To appear in May 1 issue of Phys. Rev. B, Vol. 5

A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine

Background. A novel translational pharmacology investigation was conducted by combining an in vitro efficacy target with mucosal tissue pharmacokinetic (PK) data and mathematical modeling to determine the number of doses required for effective human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP)