g/u(1)dg/u(1)^d parafermions from constrained WZNW theories

The conformal field theory based on the $g/u(1)^d$ coset construction is treated as the WZNW theory for the affine Lie algebra $\hat g$ with the constrained $\hat u(1)^d$ subalgebra.Using a modification of the generalized canonical quantization method generators and primary fields of an extended symmetry algebra are found for arbitrary d.Comment: 14 pages,latex,misprints in formulas 26,40,45 corrected,a reference adde

THE CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH THE HELP OF DISTANT ISCHEMIC AND PHARMACOLOGICAL PRECONDITIONING WITH THERMAL LOCAL ASPHYXIA OF KIDNEY

This article contains the results of research of the endothelial dysfunction arising during the modeling of thermal local asphyxia of kidney and possibilities of their correction by distant ischemic and pharmacological preconditioning. The modeling of thermal local asphyxia of kidney is characterized by the disturbance of microcirculation and expression of eNOS in the kidney tissue. The usage of distant ischemic preconditioning and phosphodiesterase inhibitors type 5 sildenafil and tadalafil leads to pronounced correction of microcirculation dysfunction and activity of eNOS. During the modeling of thermal local asphyxia of kidney against endothelium dysfunction caused by ADMA-like L-NAME induced deficiency of nitric oxide more pronounced dysfunction of microcirculation and activity of eNOS are observed. The usage of distant ischemic and pharmacological preconditioning with the help of phosphodiesterase inhibitors type 5 in this type of pathology led to pronounced correction of microcirculation dysfunction and activity of eNOS. The injection of glibenclamide blocker of ATP – dependent K+ channels during the correction of the disturbance caused by the modeling of thermal local asphyxia of kidney with the help of distant ischemic and pharmacological preconditioning leads to the decrease of its efficiency.Disclosure: The study did not have sponsorship. The authors have declared no conflicts of interest

Radio astronomical phased arrays with fiber-optic design architecture

\u3cp\u3eFiber optics and microwave photonics are considered to be the technological basis for the solution of at least the two main design problems in large radio astronomical active phased arrays (RAAPA): phase stabilized LO reference signal transmission to each antenna element or subarray; antenna array beamforming. We describe in detail the solution to the former problem. It is the experimental version of a new fiber-optic link, operating in the remote heterodyning mode, with phase stability (<1° of phase) and full compensation of the insertion loss in the RF, microwave and millimeter wave frequency regions. Two principal methods of fiber-optic beamforming in a big RAAPA are also described in detail. The first one is based on an optical true-time delay (TTD) technique to realize the classic beamforming strategy by optical means. Systems of the second kind actively use hybrid coherent optical processors, replacing the classic beamforming strategy by holographic principles and avoiding the necessity of microwave radiation delay or phase shift evaluation in every array radiator in the real-time domain.\u3c/p\u3

THE STUDY OF RENOPROTECTIVE PROPERTIES OF ERYTROPOETIN DERIVATIVES ON THE KIDNEY ISCHEMIA-REPERFUSION MODEL

Aim. The research was designed to study the renoprotective properties of erythropoietin derivatives on the kidney ischemiareperfusion experimental model.Materials and methods. The renoprotective properties of asialo erythropoietin (0.4 μg/kg and 2.4 μg/kg 30 minutes before the induction of ischemia) and carbamylated darbepoetin (50 μg/kg 24 hours before the ischemic stimulus) were studied in comparison with erythropoietin and darbepoetin in a series of experiments on male Wistar rats on a 40-minute bilateral model of renal ischemia-reperfusion. The renoprotective properties were evaluated by the results of biochemical markers of acute kidney injury, the dynamics of glomerular filtration rate and fractional sodium excretion, as well as the severity of microcirculatory disorders.Results. It was found that the prophylactic use of asialo erythropoietin (dose-dependent) and carbamylated darbepoetin leads to a decrease in the serum concentration of markers of acute renal damage, an increase in the glomerular filtration rate, a decrease in fractional sodium excretion, and a decrease in microcirculatory disorders.Conclusion. Asialo erythropoietin and carbamylated darbepoetin have the pronounced renoprotective properties and are the promising agents for the prevention and treatment of acute kidney injury