Exploring Minimal Scenarios to Produce Transversely Bright Electron Beams Using the Eigen-Emittance Concept

Next generation hard X-ray free electron lasers require electron beams with low transverse emittance. One proposal to achieve these low emittances is to exploit the eigen-emittance values of the beam. The eigen-emittances are invariant under linear beam transport and equivalent to the emittances in an uncorrelated beam. If a correlated beam with two small eigen-emittances can be produced, removal of the correlations via appropriate optics will lead to two small emittance values, provided non-linear effects are not too large. We study how such a beam may be produced using minimal linear correlations. We find it is theoretically possible to produce such a beam, however it may be more difficult to realize in practice. We identify linear correlations that may lead to physically realizable emittance schemes and discuss promising future avenues.Comment: 7 pages, 2 figures, to appear in NIM

Wavelength Dependent PSFs and their impact on Weak Lensing Measurements

We measure and model the wavelength dependence of the PSF in the Hyper Suprime-Cam (HSC) Subaru Strategic Program (SSP) survey. We find that PSF chromaticity is present in that redder stars appear smaller than bluer stars in the $g, r,$ and $i$-bands at the 1-2 per cent level and in the $z$ and $y$-bands at the 0.1-0.2 per cent level. From the color dependence of the PSF, we fit a model between the monochromatic PSF trace radius, $R$, and wavelength of the form $R(\lambda)\propto \lambda^{b}$. We find values of $b$ between -0.2 and -0.5, depending on the epoch and filter. This is consistent with the expectations of a turbulent atmosphere with an outer scale length of $\sim 10-100$ m, indicating that the atmosphere is dominating the chromaticity. We find evidence in the best seeing data that the optical system and detector also contribute some wavelength dependence. Meyers and Burchat (2015) showed that $b$ must be measured to an accuracy of $\sim 0.02$ not to dominate the systematic error budget of the Large Synoptic Survey Telescope (LSST) weak lensing (WL) survey. Using simple image simulations, we find that $b$ can be inferred with this accuracy in the $r$ and $i$-bands for all positions in the LSST field of view, assuming a stellar density of 1 star arcmin$^{-2}$ and that the optical PSF can be accurately modeled. Therefore, it is possible to correct for most, if not all, of the bias that the wavelength-dependent PSF will introduce into an LSST-like WL survey.Comment: 14 pages, 10 figures. Submitted to MNRAS. Comments welcom

Squeezed light generated by a microcavity laser

Includes bibliographical references (page 3326).Photon-number fluctuations 1.3 dB below the semiclassical shot-noise limit are observed in the output of a semiconductor microcavity laser. Although the laser oscillates in a single longitudinal mode, photon-number squeezed light is realized through nonclassical correlations between two orthogonally polarized, transverse laser modes

Novel flow cytometry approach to identify bronchial epithelial cells from healthy human airways

Sampling various compartments within the lower airways to examine human bronchial epithelial cells (HBEC) is essential for understanding numerous lung diseases. Conventional methods to identify HBEC in bronchoalveolar lavage (BAL) and wash (BW) have throughput limitations in terms of efficiency and ensuring adequate cell numbers for quantification. Flow cytometry can provide high-throughput quantification of cell number and function in BAL and BW samples, while requiring low cell numbers. To date, a flow cytometric method to identify HBEC recovered from lower human airway samples is unavailable. In this study we present a flow cytometric method identifying HBEC as CD45 negative, EpCAM/pan-cytokeratin (pan-CK) double-positive population after excluding debris, doublets and dead cells from the analysis. For validation, the HBEC panel was applied to primary HBEC resulting in 98.6% of live cells. In healthy volunteers, HBEC recovered from BAL (2.3% of live cells), BW (32.5%) and bronchial brushing samples (88.9%) correlated significantly (p = 0.0001) with the manual microscopy counts with an overall Pearson correlation of 0.96 across the three sample types. We therefore have developed, validated, and applied a flow cytometric method that will be useful to interrogate the role of the respiratory epithelium in multiple lung diseases

Are sedatives and hypnotics associated with increased suicide risk of suicide in the elderly?

<p>Abstract</p> <p>Background</p> <p>While antidepressant-induced suicidality is a concern in younger age groups, there is mounting evidence that these drugs may reduce suicidality in the elderly. Regarding a possible association between other types of psychoactive drugs and suicide, results are inconclusive. Sedatives and hypnotics are widely prescribed to elderly persons with symptoms of depression, anxiety, and sleep disturbance. The aim of this case-control study was to determine whether specific types of psychoactive drugs were associated with suicide risk in late life, after controlling for appropriate indications.</p> <p>Methods</p> <p>The study area included the city of Gothenburg and two adjacent counties (total 65+ population 210 703 at the start of the study). A case controlled study of elderly (65+) suicides was performed and close informants for 85 suicide cases (46 men, 39 women mean age 75 years) were interviewed by a psychiatrist. A population based comparison group (n = 153) was created and interviewed face-to-face. Primary care and psychiatric records were reviewed for both suicide cases and comparison subjects. All available information was used to determine past-month mental disorders in accordance with DSM-IV.</p> <p>Results</p> <p>Antidepressants, antipsychotics, sedatives and hypnotics were associated with increased suicide risk in the crude analysis. After adjustment for affective and anxiety disorders neither antidepressants in general nor SSRIs showed an association with suicide. Antipsychotics had no association with suicide after adjustment for psychotic disorders. Sedative treatment was associated with an almost fourteen-fold increase of suicide risk in the crude analyses and remained an independent risk factor for suicide even after adjustment for any DSM-IV disorder. Having a current prescription for a hypnotic was associated with a four-fold increase in suicide risk in the adjusted model.</p> <p>Conclusion</p> <p>Sedatives and hypnotics were both associated with increased risk for suicide after adjustment for appropriate indications. Given the extremely high prescription rates, a careful evaluation of the suicide risk should always precede prescribing a sedative or hypnotic to an elderly individual.</p