1,406 research outputs found
The relation between cholesterol and haemorrhagic or ischaemic stroke in the Renfrew/Paisley study
Studies have found little association between cholesterol and overall stroke risk, but this could be attributable to different relations for haemorrhagic and ischaemic stroke. Stroke mortality data from prospective studies cannot usually be divided into stroke subtypes. We have therefore analysed stroke based on hospital admissions, obtained by computerised linkage with acute hospital discharges in Scotland for a large prospective cohort study
Interpretation of vaccine associated neurological adverse events:a methodological and historical review
As a result of significant recent scientific investment, the range of vaccines available for COVID-19 prevention continues to expand and uptake is increasing globally. Although initial trial safety data have been generally reassuring, a number of adverse events, including vaccine induced thrombosis and thrombocytopenia (VITT), have come to light which have the potential to undermine the success of the vaccination program. However, it can be difficult to interpret available data and put these into context and to communicate this effectively. In this review, we discuss contemporary methodologies employed to investigate possible associations between vaccination and adverse neurological outcomes and why determining causality can be challenging. We demonstrate these issues by discussing relevant historical exemplars and explore the relevance for the current pandemic and vaccination program. We also discuss challenges in understanding and communicating such risks to clinicians and the general population within the context of the ‘infodemic’ facilitated by the Internet and other media
Fractal and Transfractal Recursive Scale-Free Nets
We explore the concepts of self-similarity, dimensionality, and
(multi)scaling in a new family of recursive scale-free nets that yield
themselves to exact analysis through renormalization techniques. All nets in
this family are self-similar and some are fractals - possessing a finite
fractal dimension - while others are small world (their diameter grows
logarithmically with their size) and are infinite-dimensional. We show how a
useful measure of "transfinite" dimension may be defined and applied to the
small world nets. Concerning multiscaling, we show how first-passage time for
diffusion and resistance between hub (the most connected nodes) scale
differently than for other nodes. Despite the different scalings, the Einstein
relation between diffusion and conductivity holds separately for hubs and
nodes. The transfinite exponents of small world nets obey Einstein relations
analogous to those in fractal nets.Comment: Includes small revisions and references added as result of readers'
feedbac
Critical behavior of cascading failures in overloaded networks
In recent years, research on spatial networks has become of widespread
interest, with the focus on analyzing critical phenomena that can dramatically
affect real systems via cascading failures and abrupt collapses. Here, we study
the breakdown of a spatial network having a characteristic link-length due to
overloads and the cascading failures that are triggered by failures of a
fraction of links. While such breakdowns have been studied extensively, the
critical exponents and the universality class of this phase transition have not
been found. Here, we show indications that this transition has features and
critical exponents which are the same as those of interdependent network
systems, suggesting that both systems are in the same universality class. We
find different abrupt transitions at the steady state, for different spatial
embedding strength. For the weakly embedded systems (i.e., link-lengths of the
order of the system size) we observe a mixed-order transition where the order
parameter collapses with time in a long plateau shape. On the other hand, in
strongly embedded systems (relatively short links), we find a pure first order
transition which involves nucleation and growth of damage. System behavior in
both limits is analogous to that observed in interdependent networks.Comment: 7 pages, 6 figure
Scale-Free Networks are Ultrasmall
We study the diameter, or the mean distance between sites, in a scale-free
network, having N sites and degree distribution p(k) ~ k^-a, i.e. the
probability of having k links outgoing from a site. In contrast to the diameter
of regular random networks or small world networks which is known to be d ~
lnN, we show, using analytical arguments, that scale free networks with 2<a<3
have a much smaller diameter, behaving as d ~ lnlnN. For a=3, our analysis
yields d ~ lnN/lnlnN, as obtained by Bollobas and Riordan, while for a>3, d ~
lnN. We also show that, for any a>2, one can construct a deterministic scale
free network with d ~ lnlnN, and this construction yields the lowest possible
diameter.Comment: Latex, 4 pages, 2 eps figures, small corrections, added explanation
Prediction of immediate ventricular arrhythmias after coronary artery ligation
AbstractObjectives. Our aim was to test the hypothesis that increased beat to beat morphologic variations in the body surface electrocardiogram (ECG) are associated with fragmented diastolic electrical activity that appears after coronary artery ligation and to correlate the appearance of spontaneous ventricular fibrillation after coronary ligation with the magnitude of the ECG beat to beat variability.Background. Unstable and variably delayed electrical activation precedes the development of ventricular fibrillation in dogs with acute ischemia. Detection of these highly variable low amplitude signals from the body surface is currently impossible. We have developed a system designed to measure the degree of beat to beat variability of the ECG.Methods. With high fidelity electrocardiography, subtle beat to beat ECG morphologic variations were detected in epicardial and body surface electrograms and quantified as the variance of the ECG voltage at specific points of the cardiac cycle. The ratio of the variance at the QRS offset to that of the QRS onset (beat to beat variability index) was then calculated.Results. Ventricular fibrillation developed in 12 of 27 dogs after left anterior descending coronary artery ligation. In 7 of the 12 dogs it occurred immediately (<15 min) after ligation; in the other 5 it developed late (15 min) after ligation. Dogs with subsequently immediate ventricular fibrillation had a significantly higher beat to beat variability index than that of dogs with late or no ventricular fibrillation both before coronary ligation (4.7 ± 1.4 vs. 1.1 ± 0.2 and 0.8 ± 0.1, respectively, p < 0.001) and after ligation (6.4 ± 2.6, 1.0 ± 0.6 and 1.2 ± 0.6, respectively, p < 0.001). In dogs that developed ventricular fibrillation immediately after coronary ligation, the arrhythmia was preceded by fragmented diastolic electrical activity on the epicardial electrogram and a simultaneous increase in the beat to beat morphologic variability of the terminal portion of the body surface ECG QRS complex.Conclusions. Beat to beat QRS offset morphologic variations appear to be increased before and further increased after coronary artery ligation in dogs that develop ventricular fibrillation immediately after ligation. Increased beat to beat variability index may be associated with the presence of electrophysiologic instability and can predict early ventricular fibrillation
Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases
Objective:
To examine the utility of the new Movement Disorder Society (MDS) diagnostic criteria in a large cohort of Parkinson's disease (PD) patients.
Methods:
Recently diagnosed (<3.5 years) PD cases fulfilling United Kingdom (UK) brain bank criteria in Tracking Parkinson's, a UK multicenter prospective natural history study were assessed by retrospective application of the MDS criteria.
Results:
In 2000 cases, 1835 (91.7%) met MDS criteria for PD, either clinically established (n = 1261, 63.1%) or clinically probable (n = 574, 28.7%), leaving 165 (8.3%) not fulfilling criteria. Clinically established cases were significantly more likely to have limb rest tremor (89.3%), a good l-dopa response (79.5%), and olfactory loss (71.1%), than clinically probable cases (60.6%, 44.4%, and 34.5% respectively), but differences between probable PD and ‘not PD’ cases were less evident. In cases not fulfilling criteria, the mean MDS UPDRS3 score (25.1, SD 13.2) was significantly higher than in probable PD (22.3, SD 12.7, p = 0.016) but not established PD (22.9, SD 12.0, p = 0.066). The l-dopa equivalent daily dose of 341 mg (SD 261) in non-PD cases was significantly higher than in probable PD (250 mg, SD 214, p < 0.001) and established PD (308 mg, SD 199, p = 0.025). After 30 months' follow-up, 89.5% of clinically established cases at baseline remained as PD (established/probable), and 86.9% of those categorized as clinically probable at baseline remained as PD (established/probable). Cases not fulfilling PD criteria had more severe parkinsonism, in particular relating to postural instability, gait problems, and cognitive impairment.
Conclusion:
Over 90% of cases clinically diagnosed as early PD fulfilled the MDS criteria for PD. Those not fulfilling criteria may have an atypical parkinsonian disorder or secondary parkinsonism that is not correctly identified by the UK Brain Bank criteria, but possibly by the new criteria
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