СЛУЧАЙ СИМУЛЬТАННОЙ ОПЕРАЦИИ У БОЛЬНОЙ РАКОМ ЛЕГКОГО В СОЧЕТАНИИ С ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА

A case of successful surgical treatment for peripheral lung cancer with concurrent coronary artery bypass for ischemic heart disease has been presented.Представлен случай успешного хирургического лечения периферического рака легкого с одновременным аортокоронарным шунтированием по поводу сопутствующей ишемической болезни сердц

Similarity Measures for Convex Polyhedra Based on Minkowski Addition

In this paper we introduce and investigate similarity measures for convex polyhedra based on Minkowski addition and inequalities for the mixed volume, volume and surface area related to the Brunn-Minkowski theory. All measures considered are invariant under translations; furthermore, they may also be invariant under subgroups of the affine transformation group. For the case of rotation and scale invariance, we prove that to obtain the measures based on (mixed) volume, it is sufficient to compute certain functionals only for a finite number of critical rotations. Extensive use is made of the slope diagram representation of convex polyhedra. AMS Subject Classification (1991): 52A38, 52B15, 68T10, 68U05 Keywords & Phrases: similarity measure, convex set, convex polyhedron, Minkowski addition, slope diagram representation, affine transformation, rotation, reflection, multiplication, similitude, volume, mixed volume, Brunn-Minkowski inequality, critical rotation, critical angle. 1 Introdu..

Available online at www.sciencedirect.com Fuzzy Setsan Systems 147 (2004) 141 -- 163

This paper is devoted to the study ofre#ectionI symmetries offuzzy objects. WeinDRIW#f a symmetry measure whichde#nM the degree ofsymmetryofan object with respect to agiven plan It is computed by measurin the similaritybetween theorigin; objectan its re#ection The choiceofan appropriate measure ofcomparison is basedon the desired properties ofthe symmetry measure.Then an algorithm forcomputin the symmetryplan offuzzy objects is proposed. This isdon usin an optimization techniza in the space ofplan parameters.Finmete we illustrate our approach withan application where the symmetry measure is used asan attributein graphmatchin for model-based objectrecognRIWBf 2003 Elsevier B.V. All rights reserved

Assessment of core-shell nanoparticles surface structure heterogeneity by SAXS contrast variation and ab initio modeling

For the biomedical applications of nanoparticles, the study of their structure is a major step towards understanding the mechanisms of their interaction with biological environment. Detailed structural analysis of particles’ surface is vital for rational design of drug delivery systems. In particular, for core-shell or surface-modified nanoparticles surface structure can be described in terms of shell coating uniformity and shell thickness uniformity around the nanoparticle core. Taken together, these terms can be used to indicate degree of heterogeneity of nanoparticle surface structure. However, characterization of nanoparticle surface structure under physiological conditions is challenging due to limitations of experimental techniques. In this paper, we apply SAXS contrast variation combined with ab initio bead modeling for this purpose. Approach is based on the fact that nanoparticles under study are produced by self-assembly of phospholipid-conjugated molecules that possess moieties with significantly different electron densities enabling SAXS technique to be used to distinguish nanoparticle shell and study its structure. Ab initio single phase and ab initio multiphase modeling based on SAXS curve of nanoparticles in phosphate buffer solution allowed to reconstruct nanoparticle shell coating and assess its uniformity, while serial nanoparticle reconstructions from solutions with gradually increased solvent electron densities revealed relative shell coating thickness around nanoparticle core. Nanoparticle shell structure representation was verified by molecular dynamics simulation and derived full-atom nanoparticle shell structure showed good agreement with SAXS-derived representation. Obtained data indicate that studied nanoparticles exhibit highly heterogeneous surface structure

Biantennary oligoglycines and glyco-oligoglycines self-associating in aqueous medium

Oligoglycines designed in a star-like fashion, so-called tri- and tetraantennary molecules, were found to form highly ordered supramers in aqueous medium. The formation of these supramers occurred either spontaneously or due to the assistance of a mica surface. The driving force of the supramer formation is hydrogen bonding, the polypeptide chain conformation is related to the folding of helical polyglycine II (PG II). Tri- and tetraantennary molecules are capable of association if the antenna length reach 7 glycine (Gly) residues. Properties of similar biantennary molecules have not been investigated yet, and we compared their self-aggregating potency with similar tri- and tetraantennary analogs. Here, we synthesized oligoglycines of the general formula R-Glyn-Х-Glyn-R (X = -HN-(СН2)m-NH-, m = 2, 4, 10; n = 1–7) without pendant ligands (R = H) and with two pendant sialoligands (R = sialic acid or sialooligosaccharide). Biantennary oligoglycines formed PG II aggregates, their properties, however, differ from those of the corresponding tri- and tetraantennary oligoglycines. In particular, the tendency to aggregate starts from Gly4 motifs instead of Gly7. The antiviral activity of end-glycosylated peptides was studied, and all capable of assembling glycopeptides demonstrated an antiviral potency which was up to 50 times higher than the activity of peptide-free glycans