542 research outputs found

    Histone H3 Acetylation is Asymmetrically Induced Upon Learning in Identified Neurons of the Food Aversion Network in the Mollusk Helix Lucorum

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    Regulation of gene expression is an essential step during long-term memory formation. Recently, the involvement of DNA-binding transcription factors and chromatin remodeling in synaptic plasticity have been intensively studied. The process of learning was shown to be associated with chromatin remodeling through histone modifications such as acetylation and phosphorylation. We have previously shown that the MAPK/ERK (mitogen-activated protein kinase/extracellular signal-regulated kinase) regulatory cascade plays a key role in the food aversion conditioning in the mollusk Helix. Specifically, command neurons of withdrawal behavior exhibit a learning-dependent asymmetry (left–right) in MAPK/ERK activation. Here, we expanded our molecular studies by focusing on a potential MAPK/ERK target – histone H3. We studied whether there is a learning-induced MAPK/ERK-dependent acetylation of histone H3 in command neurons RPa(2/3) and LPa(2/3) of the right and left parietal ganglia and whether it is asymmetrical. We found a significant learning-dependent increase in histone H3 acetylation in RPa(2/3) neurons but not in LPa(2/3) neurons. Such an increase in right command neurons depended on MAPK/ERK activation and correlated with a lateralized avoidance movement to the right visible 48 h after training. The molecular changes found in a selective set of neurons could thus represent a lateralized memory process, which may lead to consistent turning in one direction when avoiding a food that has been paired with an aversive stimulus

    NEW DATA ON AGE AND NATURE OF CARBONIZATION WITHIN SOUTHERN FLANK OF THE BAIKAL LEDGE OF THE SIBERIAN CRATON BASEMENT

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    The Baikal ledge rock formations in the Siberian craton structure are included in the Akitkan mobile belt which is considered as the Late Paleoproterozoic independent island arc system moved up to the ancient basement during the terrains amalgamation 1.91–2.00 Ga ago (Fig. 1) [Rosen, 2003; Gladkochub et al., 2009; Didenko et al., 2013].The Baikal ledge rock formations in the Siberian craton structure are included in the Akitkan mobile belt which is considered as the Late Paleoproterozoic independent island arc system moved up to the ancient basement during the terrains amalgamation 1.91–2.00 Ga ago (Fig. 1) [Rosen, 2003; Gladkochub et al., 2009; Didenko et al., 2013]

    Isolation, characterization, and metal response of novel, acid-tolerant Penicillium spp. from extremely metal-rich waters at a mining site in Transbaikal (Siberia, Russia)

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    The role of fungi in metal cycling in acidic environments has been little explored to date. In this study, two acid-tolerant and metal-resistant Penicillium isolates, strains ShG4B and ShG4C, were isolated from a mine site in the Transbaikal area of Siberia (Russia). Waters at the mine site were characterized by extremely high metal concentrations: up to 18 g lβˆ’1 Fe and >2 g lβˆ’1 each of Cu, Zn, Al, and As. Both isolates were identified as Penicillium spp. by phylogenetic analyses and they grew well in Czapek medium acidified to pH 2.5. Resistance to Cu, Cd, Ni, Co, and arsenate was in the range of 1–10 g lβˆ’1. Further experiments with Penicillium strain ShG4C demonstrated that growth in Cu-containing media was accompanied by the precipitation of Cu-oxalate (moolooite) and the formation of extracellular vesicles enriched in Cu on the mycelia. Vesicles were greatly reduced in size in Cd-containing media and were not formed in the presence of Ni or Co. Cd-oxalate was detected as a crystalline solid phase in Cd-exposed mycelia. Hydrated Nisulfate (retgersite) and Co-sulfate (bieberite) were detected in mycelia grown in the presence of Ni and Co, respectively. The results demonstrated that acid-tolerant and metal-resistant Penicillium constitute a component in extremophilic microbiomes, contributing to organic matter breakdown and formation of secondary solid phases at pH ranges found in acid rock drainage

    Rationale for endomyocardial biopsy in the diagnosis of heart disease in children and adults

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    Endomyocardial biopsy (EMB) is the method of choice for diagnosing a wide range of myocardial diseases.Aim. To assess the rationale for diagnostic EMB in children and adults.Material and methods. Morphological and statistical analysis of 2803 diagnostic EMBs in adults (n=811) and children (n=83), including those in heart transplantation (n=1909), was carried out.Results. In 231 (28%) cases, adults were diagnosed with myocarditis, of which in 6 patients β€” granulomatous, in 5 β€” eosinophilic and in 6 β€” lymphocytic-macrophage myocarditis after coronavirus infection. In children, myocarditis was found in 22 cases (27%). Arrhythmogenic right ventricular dysplasia took the second place in detection rate in children and adults. Immunohistochemical study revealed viral envelope protein 1 (VP1) antigen of enteroviruses in one third of myocarditis cases, and in half β€” other cardiotropic viruses. Dotted dystrophin expression was observed in myocarditis. A correlation was established between the perforin expression and myocarditis presence (Pearson Ο‡2=27,8; Fisher's exact test=27,3; p=0,01).Conclusion. Analysis of diagnostic EMB results confirmed its rationale in adults and children not only for heart transplantation, but also for identifying cardiac pathology, including for myocarditis diagnosis. It has been shown that immunohistochemical study with antiviral antibodies can be considered as an alternative method for detecting viral infection. An immunohistochemical analysis for perforin and dystrophin can be recommended as additional morphological markers of myocarditis

    High energy hadrons in EAS at mountain altitude

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    An extensive simulation has been carried out to estimate the physical interpretation of dynamical factors such as , in terms of high energy interaction features, concentrated in the present analysis on the average transverse momentum. It appears that the large enhancement observed for versus primary energy, suggesting in earliest analysis a significant rise of with energy, is only the result of the limited resolution of the detectors and remains in agreement with a wide range of models used in simulations.Comment: 13 pages, 6 PostScript figures, LaTeX Subm. to JPhys

    ISOTOPE COMPOSITION OF CARBON AND OXYGEN IN CALCITES OF ALKALINE ULTRAMAPHIC DYKES WITHIN THE URIK-IYA GRABEN

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    The isotope composition of carbon and oxygen was studied in calcite of dykes and veins of ultramafic lamprophyres, kimberlite, alkaline mica picrites from the Yarma above-intrusion zone, and pyroxene-free picrites intruding the rocks of the Bolshetagninsky carbonatite massif within the Urik-Iya graben hosted by the East Sayan Mountains. The data on Ξ΄13C (from βˆ’6.6 to βˆ’3.9 ‰ relative to VPDB) disclose the ideas on the mantle origin of the carbonate substance of dykes. High values of Ξ΄18O (from +13.9 to +11.8 ‰ relative to VSMOW) suggest the impact of deuteric fluids, i.e. magmatic fluids separated from melts, at later stage of formation of the calcite-bearing alkaline ultramafic rocks

    Π˜ΠœΠœΠ£ΠΠžΠ’Π•Π ΠΠŸΠ˜Π― НА ΠžΠ‘ΠΠžΠ’Π• Π”Π•ΠΠ”Π Π˜Π’ΠΠ«Π₯ ΠšΠ›Π•Π’ΠžΠš Π’ Π›Π•Π§Π•ΠΠ˜Π˜ РАКА ΠœΠžΠ§Π•Π’ΠžΠ“Πž ΠŸΠ£Π—Π«Π Π―

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    The development of an antitumor vaccine based on autologous dendritic cells (DCs) for bladder cancer treatment is extremely relevant today due to the proven high immunological potency of this type of tumor. Vaccination with DCs-based drugs as a monotherapy or in combination with other methods of treatment has shown to be effective in cancer therapy. The vaccine administration is considered to be safe, the associated side effects are insignificant and can be characterized as undesirable phenomena of 1st or 2nd degree. There are a number of issues that arise while creating DCs vaccines that need to be carefully resolved. Among them, the problem of selecting potential targets for the vaccine treatment, the ways to enhance the potency of the vaccine, and the selection of technology for obtaining a sufficient number of functional DCs should be specifically mentioned. The review focuses on the use of autoantigen or alloantibody material for the activation of DCs, and the results of experimental and clinical studies of DCs vaccines in bladder cancer.Π Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²ΠΎΠΉ Π²Π°ΠΊΡ†ΠΈΠ½Ρ‹ для Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ Ρ€Π°ΠΊΠ° ΠΌΠΎΡ‡Π΅Π²ΠΎΠ³ΠΎ пузыря Π½Π° основС Π°ΡƒΡ‚ΠΎΠ»ΠΎΠ³ΠΈΡ‡Π½Ρ‹Ρ… Π΄Π΅Π½Π΄Ρ€ΠΈΡ‚Π½Ρ‹Ρ… ΠΊΠ»Π΅Ρ‚ΠΎΠΊ (Π”Πš) Π½Π° сСгодняшний дСнь вСсьма Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Π° Π² связи с Π΄ΠΎΠΊΠ°Π·Π°Π½Π½ΠΎΠΉ высокой ΠΈΠΌΠΌΡƒΠ½ΠΎΠ³Π΅Π½Π½ΠΎΡΡ‚ΡŒΡŽ этого Π²ΠΈΠ΄Π° ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ. Вакцинация ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π°ΠΌΠΈ Π½Π° основС Π”Πš дСмонстрируСт ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ Π² Π±ΠΎΡ€ΡŒΠ±Π΅ с онкологичСскими заболСваниями Π² качСствС ΠΌΠΎΠ½ΠΎΡ‚Π΅Ρ€Π°ΠΏΠΈΠΈ ΠΈ Π² сочСтании с Π΄Ρ€ΡƒΠ³ΠΈΠΌΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Π°ΠΌΠΈ лСчСния. ΠŸΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Ρ‚Π°ΠΊΠΈΡ… Π²Π°ΠΊΡ†ΠΈΠ½ считаСтся бСзопасным, Ρ‚Π°ΠΊ ΠΊΠ°ΠΊ связанныС с Π½ΠΈΠΌ ΠΏΠΎΠ±ΠΎΡ‡Π½Ρ‹Π΅ эффСкты Π½Π΅Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ ΠΈ ΠΌΠΎΠ³ΡƒΡ‚ Π±Ρ‹Ρ‚ΡŒ ΠΎΡ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€ΠΈΠ·ΠΎΠ²Π°Π½Ρ‹ ΠΊΠ°ΠΊ Π½Π΅ΠΆΠ΅Π»Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ явлСния I ΠΈΠ»ΠΈ II стСпСни. ΠŸΡ€ΠΈ создании Π”Πš-Π²Π°ΠΊΡ†ΠΈΠ½ Π²ΠΎΠ·Π½ΠΈΠΊΠ°Π΅Ρ‚ ряд аспСктов, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΉ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎ Ρ‚Ρ‰Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎ ΠΏΡ€ΠΎΡ€Π°Π±ΠΎΡ‚Π°Ρ‚ΡŒ. Π‘Ρ€Π΅Π΄ΠΈ Π½ΠΈΡ… слСдуСт особСнно Π²Ρ‹Π΄Π΅Π»ΠΈΡ‚ΡŒ ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΡƒ ΠΏΠΎΠ΄Π±ΠΎΡ€Π° ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… мишСнСй для воздСйствия Π²Π°ΠΊΡ†ΠΈΠ½ΠΎΡ‚Π΅Ρ€Π°ΠΏΠΈΠΈ, способов усилСния иммуногСнности Π²Π°ΠΊΡ†ΠΈΠ½Ρ‹, Π²Ρ‹Π±ΠΎΡ€Π° Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ получСния достаточного количСства Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… Π”Πš. Π’ ΠΎΠ±Π·ΠΎΡ€Π΅ ΡƒΠ΄Π΅Π»Π΅Π½ΠΎ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ вопросам использования Π°ΡƒΡ‚ΠΎΠ»ΠΎΠ³ΠΈΡ‡Π½ΠΎΠ³ΠΎ ΠΈ Π°Π»Π»ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ Π°Π½Ρ‚ΠΈΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Π° для Π°ΠΊΡ‚ΠΈΠ²Π°Ρ†ΠΈΠΈ Π”Πš, Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°ΠΌ ΡΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Ρ‹Ρ… ΠΈ клиничСских исслСдований Π”Πš-Π²Π°ΠΊΡ†ΠΈΠ½ ΠΏΡ€ΠΈ Ρ€Π°ΠΊΠ΅ ΠΌΠΎΡ‡Π΅Π²ΠΎΠ³ΠΎ пузыря

    БтрСсс-тСстированиС развития Ρ€Π΅Π³ΠΈΠΎΠ½ΠΎΠ² России Π² условиях Π²Π½Π΅ΡˆΠ½Π΅ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡ‡Π΅ΡΠΊΠΈΡ… ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡Π΅Π½ΠΈΠΉ

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    Purpose: is to develop the model for stress testing of the impact of external constraints of Russian regions in the context of foreign economic constraints 2022–2023.Methods: the research is based on the theory of economic dynamics, regional economy and spatial development, the concept of the BANI world; the methodological basis of the study is a scenario approach to the formation of the stress testing model and the algorithm for determining the expected impact based on the machine learning method – the artificial neural network.Results: the study of scientific publications on the research topic, analysis of shock events, post-shock consequences (2006–2022) made it possible to substantiate feasibility of testing and differentiating the response of Russian regions to external constraints, applying the criteria of β€œshock-resistant” development, classifying economic space and identifying the territory with β€œshock-resistant” and β€œnon-shockresistant”reactions. The model of regions stress testing has been developed, industrial and sectoral (67.6% importance) and spatial (32.4%) stabilization factors have been identified, areas of vulnerability to the restrictions of 2022-2023 and industrial regions with the potential for β€œnon-shock-resistant” type of reaction have been identified.Conclusions and Relevance: the reaction of regions to external economic shocks (the duration of the decline period and the intensity of recovery growth) is determined by the totality of the production and spatial characteristics of the regions. The results of the study are important for the development of the theory of regional economy; they can be used byfederal and regional executive authorities of the Russian Federation.ЦСль исслСдования – Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Ρ‚ΡŒ модСль стрСсс-тСстирования влияния Π²Π½Π΅ΡˆΠ½ΠΈΡ… ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡Π΅Π½ΠΈΠΉ Π½Π° экономику Ρ€Π΅Π³ΠΈΠΎΠ½ΠΎΠ² ΠΈ провСсти диагностику ударопрочности развития Π² условиях Ρ€Π΅Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ ΡˆΠΎΠΊΠΎΠ²Ρ‹Ρ… событий.ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹. ИсслСдованиС базируСтся Π½Π° ΠΊΠΎΠ½Ρ†Π΅ΠΏΡ†ΠΈΠΈ BANI-ΠΌΠΈΡ€Π°, тСориях экономичСской Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΠΈ шоков, Ρ‚Π΅ΠΎΡ€ΠΈΠΈ пространствСнной экономики. ΠœΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠ° исслСдования Π²ΠΊΠ»ΡŽΡ‡Π°Π΅Ρ‚ ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ сцСнарного ΠΏΠΎΠ΄Ρ…ΠΎΠ΄Π° ΠΏΡ€ΠΈ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ стрСсс-тСстирования Ρ€Π΅Π³ΠΈΠΎΠ½ΠΎΠ², Π°Π»Π³ΠΎΡ€ΠΈΡ‚ΠΌΠ° ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ Β«ΠΎΠΆΠΈΠ΄Π°Π΅ΠΌΠΎΠ³ΠΎ воздСйствия» шока Π½Π° основС ΠΌΠ΅Ρ‚ΠΎΠ΄Π° машинного обучСния – искусствСнной Π½Π΅ΠΉΡ€ΠΎΠ½Π½ΠΎΠΉ сСти.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ Ρ€Π°Π±ΠΎΡ‚Ρ‹. ΠžΠ±ΠΎΠ±Ρ‰Π΅Π½ΠΈΠ΅ Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… ΠΏΡƒΠ±Π»ΠΈΠΊΠ°Ρ†ΠΈΠΉ ΠΏΠΎ Ρ‚Π΅ΠΌΠ΅ исслСдования, Π°Π½Π°Π»ΠΈΠ· ΡˆΠΎΠΊΠΎΠ²Ρ‹Ρ… событий, ΠΏΠΎΡΡ‚ΡˆΠΎΠΊΠΎΠ²Ρ‹Ρ… послСдствий (2006–2022 Π³Π³.) ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΈ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Ρ‚ΡŒ Ρ‚Π΅ΠΎΡ€Π΅Ρ‚ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ ΠΈ ΠΏΡ€ΠΈΠΊΠ»Π°Π΄Π½ΡƒΡŽ Ρ†Π΅Π»Π΅ΡΠΎΠΎΠ±Ρ€Π°Π·Π½ΠΎΡΡ‚ΡŒ тСстирования ΠΈ Π΄ΠΈΡ„Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΠ°Ρ†ΠΈΠΈ Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ российских Ρ€Π΅Π³ΠΈΠΎΠ½ΠΎΠ² Π½Π° внСшниС ограничСния, ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΡ€ΠΈΡ‚Π΅Ρ€ΠΈΠ΅Π² «ударопрочности» развития, классификации экономичСского пространства ΠΈ ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ Ρ‚Π΅Ρ€Ρ€ΠΈΡ‚ΠΎΡ€ΠΈΠΉ с Β«ΡƒΠ΄Π°Ρ€ΠΎΠΏΡ€ΠΎΡ‡Π½ΠΎΠΉΒ» ΠΈ Β«Π½Π΅ΡƒΠ΄Π°Ρ€ΠΎΠΏΡ€ΠΎΡ‡Π½ΠΎΠΉΒ» Ρ€Π΅Π°ΠΊΡ†ΠΈΠ΅ΠΉ Π½Π° шоки. Π Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Π° модСль стрСсс-тСстирования Ρ€Π΅Π³ΠΈΠΎΠ½ΠΎΠ², ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ производствСнно-отраслСвыС (67,6% ваТности) ΠΈ пространствСнныС (32,4%) Ρ„Π°ΠΊΡ‚ΠΎΡ€Ρ‹ стабилизации, ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ Π·ΠΎΠ½Ρ‹ уязвимости ΠΊ ограничСниям 2022–2023 Π³Π³., ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Ρ‹ ΠΈΠ½Π΄ΡƒΡΡ‚Ρ€ΠΈΠ°Π»ΡŒΠ½Ρ‹Π΅ Ρ€Π΅Π³ΠΈΠΎΠ½Ρ‹ с ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΠΎΠΌ Β«Π½Π΅ΡƒΠ΄Π°Ρ€ΠΎΠΏΡ€ΠΎΡ‡Π½ΠΎΠ³ΠΎΒ» развития экономики ΠΏΡ€ΠΈ ΡˆΠΎΠΊΠΎΠ²Ρ‹Ρ… Π½Π°Π³Ρ€ΡƒΠ·ΠΊΠ°Ρ….Π’Ρ‹Π²ΠΎΠ΄Ρ‹. РСакция Ρ€Π΅Π³ΠΈΠΎΠ½ΠΎΠ² Π½Π° внСшниС шоки ΠΈ ограничСния (Π΄Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π° сниТСния ΠΈ ΠΈΠ½Ρ‚Π΅Π½ΡΠΈΠ²Π½ΠΎΡΡ‚ΡŒ Π²ΠΎΡΡΡ‚Π°Π½ΠΎΠ²ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ роста) спСцифична ΠΈ опрСдСляСтся сочСтаниСм ΡƒΠ½ΠΈΠΊΠ°Π»ΡŒΠ½Ρ‹Ρ… пространствСнных ΠΈ производствСнных характСристик Ρ€Π΅Π³ΠΈΠΎΠ½ΠΎΠ². Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ исслСдования Π² части тСорСтичСских Π²Ρ‹Π²ΠΎΠ΄ΠΎΠ² ΠΎ нСоднородности Ρ€Π΅Π³ΠΈΠΎΠ½ΠΎΠ² с ΠΏΠΎΠ·ΠΈΡ†ΠΈΠΈ Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ Π½Π° внСшниС ограничСния ΠΈ мСтодичСского ΠΏΠΎΠ΄Ρ…ΠΎΠ΄Π° ΠΊ стрСсс-Ρ‚Π΅ΡΡ‚ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΡŽ ΠΈΡ… развития Ρ€Π°ΡΡˆΠΈΡ€ΡΡŽΡ‚ Ρ‚Π΅ΠΎΡ€ΠΈΡŽ пространствСнной экономики, ΠΈΠΌΠ΅ΡŽΡ‚ ΠΏΡ€ΠΈΠΊΠ»Π°Π΄Π½ΠΎΠ΅ Π·Π½Π°Ρ‡Π΅Π½ΠΈΠ΅ для ΠΎΡ†Π΅Π½ΠΊΠΈ «ударопрочности» ΡΡƒΠ±ΡŠΠ΅ΠΊΡ‚ΠΎΠ² Π Π€, прогнозирования экономичСского развития, формирования стратСгии государствСнного управлСния Ρ€Π΅Π³ΠΈΠΎΠ½Π°ΠΌΠΈ
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