Understanding constraint expressions in large conceptual schemas by automatic filtering

Human understanding of constraint expressions (also called schema rules) in large conceptual schemas is very di cult. This is due to the fact that the elements (entity types, attributes, relationship types) involved in an expression are de ned in di fferent places in the schema, which may be very distant from each other and embedded in an intricate web of irrelevant elements. The problem is insignifi cant when the conceptual schema is small, but very signi cant when it is large. In this paper we describe a novel method that, given a set of constraint expressions and a large conceptual schema, automatically filters the conceptual schema, obtaining a smaller one that contains the elements of interest for the understanding of the expressions. We also show the application of the method to the important case of understanding the specication of event types, whose constraint expressions consists of a set of pre and postconditions. We have evaluated the method by means of its application to a set of large conceptual schemas. The results show that the method is eff ective and e cient. We deal with conceptual schemas in UML/OCL, but the method can be adapted to other languages.Peer ReviewedPreprin

Intra-islet insulin synthesis defects are associated with endoplasmic reticulum stress and loss of beta cell identity in human diabetes

Aims/hypothesis: Endoplasmic reticulum (ER) stress and beta cell dedifferentiation both play leading roles in impaired insulin secretion in overt type 2 diabetes. Whether and how these factors are related in the natural history of the disease remains, however, unclear. Methods: In this study, we analysed pancreas biopsies from a cohort of metabolically characterised living donors to identify defects in in situ insulin synthesis and intra-islet expression of ER stress and beta cell phenotype markers. Results: We provide evidence that in situ altered insulin processing is closely connected to in vivo worsening of beta cell function. Further, activation of ER stress genes reflects the alteration of insulin processing in situ. Using a combination of 17 different markers, we characterised individual pancreatic islets from normal glucose tolerant, impaired glucose tolerant and type 2 diabetic participants and reconstructed disease progression. Conclusions/interpretation: Our study suggests that increased beta cell workload is accompanied by a progressive increase in ER stress with defects in insulin synthesis and loss of beta cell identity. Graphical abstract: [Figure not available: see fulltext.

Medication errors in the emergency department. knowledge, attitude, behavior, and training needs of nurses

Aim: The aim was to describe which elements of nurses’ knowledge, training needs, behavior, and attitude can prevent Medication errors (Acronym MEs) in the emergency department during all steps of the administration of intravenous (IV) medications. Methods: An anonymousquestionnaire made up of 43 items has been drafted and delivered to a sample of 103 nurses of a university hospital in Rome. The study has been supported by specific literature review. Results: Majority of the sample (94%) answered that topics related to the preparation and administration of IV medications were covered during the basic course while 63.2% only during the postbasic course. Only 15.6% of nurses judged excellent their level of knowledge about preparation and administration of IV medications while 89.3% considered that it is important to improve their knowledge; 85.6% said that the teaching about the use of IV medications should be increased during the degree course they attended; 30.3% agreed that specific postgraduate courses on the use of IV drugs should be designed. Moreover, only 22% of the sample believed that the coaching of new recruit nurses is critical to prevent errors. Conclusion: The sample showed appropriate knowledge, positive attitudes, and right behavior related to the preparation and administration of IV medications. The skills that nurses must have in pharmacology are still rising, both due to the safety of drug therapy and to the increasing number of drugs available; the result is that nurses have to update their knowledge regularly

SUPER: Visual Interfaces for Object + Relationship Data Models

SUPER is an exploratory project into the next generation of user-DBMS interfaces. Its main objective is to demonstrate that a visual paradigm can lead to powerful and user-friendly interfaces supporting all phases of the database life cycle (i.e. creation, manipulation and evolution). Visual interaction in SUPER is based on direct manipulation of objects and functions, with a special focus on providing users with maximum flexibility and independence from database technicalities. The set of tools offers facilities to meet the varied demands from categories of users with different levels of skill. Diagrammatic representations and a basic set of functions are better suited for novice and occasional users, while menus and dialog boxes speed up the dialog for expert users. At the same times a consistent interaction style over the various functions and tools has been emphasized. SUPER has been designed as a front end to a relational or an object-oriented DBMS, i.e. the persistence of data, consistency and concurrency problems are delegated to an off-the-shelf database management system. The current prototype supports schema definition, query formulation and browsing using a powerful data model based on objects and relationships