Limit quantum efficiency for violation of Clauser-Horne Inequality for qutrits

In this paper we present the results of numerical calculations about the minimal value of detection efficiency for violating the Clauser - Horne inequality for qutrits. Our results show how the use of non-maximally entangled states largely improves this limit respect to maximally entangled ones. A stronger resistance to noise is also found.Comment: Phys. Rev. A in pres

Price Competition, Fluctuations, and Welfare Guarantees

In various markets where sellers compete in price, price oscillations are observed rather than convergence to equilibrium. Such fluctuations have been empirically observed in the retail market for gasoline, in airline pricing and in the online sale of consumer goods. Motivated by this, we study a model of price competition in which an equilibrium rarely exists. We seek to analyze the welfare, despite the nonexistence of an equilibrium, and present welfare guarantees as a function of the market power of the sellers. We first study best response dynamics in markets with sellers that provide a homogeneous good, and show that except for a modest number of initial rounds, the welfare is guaranteed to be high. We consider two variations: in the first the sellers have full information about the valuation of the buyer. Here we show that if there are $n$ items available across all sellers and $n_{\max}$ is the maximum number of items controlled by any given seller, the ratio of the optimal welfare to the achieved welfare will be at most $\log(\frac{n}{n-n_{\max}+1})+1$. As the market power of the largest seller diminishes, the welfare becomes closer to optimal. In the second variation we consider an extended model where sellers have uncertainty about the buyer's valuation. Here we similarly show that the welfare improves as the market power of the largest seller decreases, yet with a worse ratio of $\frac{n}{n-n_{\max}+1}$. The exponential gap in welfare between the two variations quantifies the value of accurately learning the buyer valuation. Finally, we show that extending our results to heterogeneous goods in general is not possible. Even for the simple class of $k$-additive valuations, there exists a setting where the welfare approximates the optimal welfare within any non-zero factor only for $O(1/s)$ fraction of the time, where $s$ is the number of sellers

Fibroblast Growth Factor-2 Enhances Expansion of Human Bone Marrow-Derived Mesenchymal Stromal Cells without Diminishing Their Immunosuppressive Potential

Allogeneic hematopoietic stem cell transplantation is the main curative therapy for many hematologic malignancies. Its potential relies on graft-versus-tumor effects which associate with graft-versus-host disease. Mesenchymal stromal cells (MSCs) possess immunomodulatory properties that make them attractive therapeutic alternatives. We evaluated the in vitro immunosuppressive activity of medium conditioned by human MSCs from 5 donors expanded 13 passages with or without FGF-2. FGF-2 supplementation increased expansion 3,500- and 240,000-fold by passages 7 and 13, respectively. There were no differences in immunosuppressive activity between media conditioned by passage-matched cells expanded under different conditions, but media conditioned by FGF-treated MSCs were superior to population doubling-matched controls. The immunosuppressive activity was maintained in three of the preparations but decreased with expansion in two. The proliferation induced by FGF-2 did not result in loss of immunosuppressive activity. However, because the immunosuppressive activity was not consistently preserved, caution must be exercised to ensure that the activity of the cells is sufficient after extensive expansion

Labelling and clinical performance of human leukocytes labelled with 99m Tc-HMPAO using leukokit® with gelofusine versus leukokit® with HES as sedimentation agent

The scintigraphy with radiolabelled autologous leukocytes (WBCs) is considered the gold-standard technique for imaging infections. Leukokit (R) is a commercially available, disposable, sterile kit for labelling WBCs ex vivo. In this kit, WBCs isolation from red blood cells (RBCs) was performed using poly(O-2-hydroxyethyl)starch (HES) as the RBCs sedimentation agent. Due to its poor availability, HES has been recently replaced by Gelofusine as the RBC sedimentation agent. The aim of this study was to compare the labelling efficiency and the diagnostic accuracy of WBCs labelled with Leukokit (R) with HES vs Leukokit (R) with Gelofusine. WBCs were isolated using HES or Gelofusine for 45minutes and then purified from platelets (PLTs) and labelled with 1.1 +/- 0.3 GBq of freshly prepared Tc-99m- HMPAO. The following parameters were evaluated: the number and type of recovered WBCs, RBCs contamination, PLTs contamination, vitality of neutrophils, and chemotactic properties of neutrophils. Clinical comparison was performed between 80 patients (33 males; age 67.5 +/- 14.2) injected with Tc-99m-HMPAO-WBCs, using HES as the sedimentation agent, and 92 patients (38 males; age 68.2 +/- 12.8) injected with Tc-99m-HMPAO-WBCs using Gelofusine as the sedimentation agent. Patients were affected by prosthetic joint infections, peripheral bone osteomyelitis, or vascular graft infection. We compared radiolabelling efficiency (LE), final recovery yield (RY), and diagnostic outcome based on microbiology or 2-year follow-up. Results showed that HES provides the lowest RBCs and PLTs contamination, but Gelofusine provides the highest WBC recovery. Both agents did not influence the chemotactic properties of WBCs, and no differences were found in terms of LE and RY. Sensitivity, specificity, and accuracy were also not significantly different for WBCs labelled with both agents (diagnostic accuracy 90.9%, CI = 74.9-96.1 vs 98.3%, CI = 90.8-100, for HES and Gelofusine, respectively). In conclusion, Gelofusine can be considered a suitable alternative of HES for WBCs separation and labelling

The Measurement Process in Local Quantum Theory and the EPR Paradox

We describe in a qualitative way a possible picture of the Measurement Process in Quantum Mechanics, which takes into account: 1. the finite and non zero time duration T of the interaction between the observed system and the microscopic part of the measurement apparatus; 2. the finite space size R of that apparatus; 3. the fact that the macroscopic part of the measurement apparatus, having the role of amplifying the effect of that interaction to a macroscopic scale, is composed by a very large but finite number N of particles. The conventional picture of the measurement, as an instantaneous action turning a pure state into a mixture, arises only in the limit in which N and R tend to infinity, and T tends to 0. We sketch here a proposed scheme, which still ought to be made mathematically precise in order to analyse its implications and to test it in specific models, where we argue that in Quantum Field Theory this picture should apply to the unique time evolution expressing the dynamics of a given theory, and should comply with the Principle of Locality. We comment on the Einstein Podolski Rosen thought experiment (partly modifying the discussion on this point in an earlier version of this note), reformulated here only in terms of local observables (rather than global ones, as one particle or polarisation observables). The local picture of the measurement process helps to make it clear that there is no conflict with the Principle of Locality.Comment: 18 page

In vitro and in vivo evaluation of 99mTc-polymyxin B for specific targeting of gram-bacteria

Background: Infectious diseases are one of the main causes of morbidity and mortality worldwide. Nuclear molecular imaging would be of great help to non-invasively discriminate between septic and sterile inflammation through available radiopharmaceuticals, as none is currently available for clinical practice. Here, we describe the radiolabeling procedure and in vitro and in vivo studies of99mTc-polymyxin B sulfate (PMB) as a new single photon emission imaging agent for the characterization of infections due to Gram-negative bacteria. Results: Labeling efficiency was 97 ± 2% with an average molar activity of 29.5 ± 0.6 MBq/nmol. The product was highly stable in saline and serum up to 6 h. In vitro binding assay showed significant displaceable binding to Gram-negative bacteria but not to Gram-positive controls. In mice,99mTc-HYNIC-PMB was mainly taken up by liver and kidneys. Targeting studies confirmed the specificity of99mTc-HYNIC-PMB obtained in vitro, showing significantly higher T/B ratios for Gram-negative bacteria than Gram-positive controls. Conclusions: In vitro and in vivo results suggest that99mTc-HYNIC-PMB has a potential for in vivo identification of Gram-negative bacteria in patients with infections of unknown etiology. However, further investigations are needed to deeply understand the mechanism of action and behavior of99mTc-HYNIC-PMB in other animal models and in humans

A first experimental test of de Broglie-Bohm theory against standard quantum mechanics

De Broglie - Bohm (dBB) theory is a deterministic theory, built for reproducing almost all Quantum Mechanics (QM) predictions, where position plays the role of a hidden variable. It was recently shown that different coincidence patterns are predicted by QM and dBB when a double slit experiment is realised under specific conditions and, therefore, an experiment can test the two theories. In this letter we present the first realisation of such a double slit experiment by using correlated photons produced in type I Parametric Down Conversion. Our results confirm QM contradicting dBB predictions

The use of platelet-rich plasma for treatment of tenodesmic lesions in horses: A systematic review and meta-analysis of clinical and experimental data

The use of platelet-rich plasma (PRP) to enhance tenodesmic lesion healing has been questioned over the years. The aim of this study was to evaluate current literature to establish the effectiveness of PRP for treating tenodesmic lesions through a systematic review, in accordance with the PRISMA guidelines, and a meta-analysis. Studies comparing PRP with placebo or other treatments for horses with tenodesmic injuries or evaluated PRP effect on tendon and ligament explants were included. Outcomes were clinical, ultrasound, histologic, molecular evaluation, and adverse effects. Two authors independently extracted data and assessed each study’s risk of bias. Treatment effects were evaluated using risk ratios for dichotomous data, together with 95% CI. Data were pooled using the random-effects model. The quality of the evidence for each outcome was assessed using GRADE criteria. Twenty-four trials met inclusion criteria for systematic review, while fifteen studies were included in the meta-analysis. Results showed no significant differences in the outcomes between PRP and control groups. Finally, there is no definitive evidence that PRP enhances tendons and ligaments healing. Therefore, there is a need for more controlled trials to draw a firmer conclusion about the efficacy of PRP as a treatment for tenodesmic lesions in the horse