EXPERIENCE IN THE DEVELOPMENT AND IMPLEMENTATION OF THE MODULE AUTOMATE THE PROCESS OF CREATING AND APPROVING PROGRAMS OF STUDY WITHIN THE INFORMATION EDUCATIONAL ENVIRONMENT OF SUPPORT OF THE BASIC EDUCATIONAL PROCESS

It describes the trends in the development and implementation experience in the educational process of the University of modern information technologies on the example of the information educational environment to support the basic education process. As an example of the approach to the introduction of information technologies in educational process describes the experience of the development and implementation of the module automate the creation and approval of training courses in the framework of the information educational environment to support basic education process VPO “National Research University” Higher School of Economics”

Experience in development, trends in the development and implementation of information systems supporting the main educational process

This article contents experience of use and description of tendencies of educational information systems extension with emphasis on institutions of higher education. In the context of the emergence of new educational needs, changes in the principles of access to knowledge, including the requirements to generalize existing ones and introduce new approaches to formalizing and systematizing data collection and accumulation, taking into account the specifics of a particular field of education, it becomes urgent to introduce information systems for supporting the educational process and to realize the needs of a single organization educational information space both at the level of a particular institution and the educational system as a whole. As a result of the analysis of components of the main educational process and the field of educational information systems development and deployment within creation of a common information space, authors state a relevant problem of information processes formalization and specification of discipline programs creation with the subsequent development of a universal information systems component

Patterns of the association among ultrasound, hemodynamic and biochemical parameters of atherosclerosis of the carotid and coronary arteries in patients with coronary heart disease

An increase in the proportion of comorbid cardiac patients with primary nosologies such as arterial hypertension and atherosclerosis actualizes the search for optimal approaches to their diagnosis and treatment. The emerging pathogenetic mechanisms of concomitant diseases must be taken into account on an individual basis. Aim of the study was to investigate the patterns of atherosclerotic changes in carotid arteries in patients with coronary heart disease who underwent percutaneous transluminal angioplasty and their correlation with biochemical and hemodynamic markers of atherosclerosis. Material and methods. 53 patients with coronary heart disease (CHD) were examined and treated in the clinic of the Federal Research Center of Fundamental and Translational Medicine. The average age of the patients was 64.73 ± 1.66 years. A comprehensive clinical laboratory examination was conducted, including the blood lipids test to measure content of total cholesterol, low- and high-density lipoprotein cholesterol, triglycerides, as well as serum markers of systemic inflammation (concentration of C-reactive protein (CRP), fibrinogen, erythrocyte sedimentation rate (ESR)) and carotid artery duplex scan. Results. A direct correlation between the severity of atherosclerotic changes in the carotid arteries and indicators of systemic inflammation, i.e. CRP, ESR and fibrinogen was found. The study also revealed greater severity of atherosclerotic stenosis of the carotid arteries in patients with coronary artery disease who underwent percutaneous transluminal coronary angioplasty with coronary artery stenting compared to patients without any intervention. Conclusion. The obtained data indicate the effectiveness of ultrasound scan of the carotid arteries for the early diagnosis of multifocal atherosclerosis for timely treatment and prevention of cardiovascular polymorbidity in patients with a cardiovascular profile

EXPERIENCE AND TRENDS OF TRAINIG SPECIALISTS IN THE FIELDS OF MATHMATICAL METHODS AND INFORMATION TECHNOLOGY IN HEALTH CARE

The article describes the experience of implementing educational programs for bachelors and masters with focus on areas of training in the field of computer science with the introduction into educational process modern technologies, attracting the largest enterprises-employers and experts of the subject domain. As an example of this approach, describes the implementation of educational programs at the intersection of information technology and health care, and especially their Information Technology Services

Levels of marker lysosomal hydrolases in women with coronary heart disease depending on age and sex hormone level

Aim of the study was to evaluate the serum concentrations of three marker lysosomal hydrolases (cathepsin D, acid phosphatase (AP) and acid DNase (aDNAase)) in women with coronary heart disease (CHD) depending on the level of follicle-­stimulating hormone (FSH), testosterone (T), age and find if those parameters associated with anthropometric parameters, glycemia, insulinemia and HOMA-IR index, biomarkers of atherosclerosis. The study included 285 women aged 35–65 years (median age was 54.4 years (25% and 75% percentiles — 43.2 and 61.3 years, respectively) who had had myocardial infarction no earlier than 30 days before the examination. Patients were divided into the following age groups: 35–55 and 56–65 years (first and second age groups, respectively), and into groups according to the levels of sex hormones: FSH ≥ and <30 mIU/mL and testosterone ≥ and <3 nmol/L. Results of comparative and correlation analyzes demonstrates that in women 35–65 years old with FSH ≥30 mIU/mL, the levels of cathepsin D are higher (p<0.05) than in patients with FSH <30 mIU/mL, and in women 35–55 years old, the content of AP was also higher (p=0.025). Associations of a high level of androgen with lysosomal hyperenzymemia were demonstrated only in the second age group, where at a level of T ≥3 nmol/L, higher values of all three lysosomal enzymes were recorded. Multivariate analysis in both age groups is confirmed direct impact of periand postmenopausal periods on the levels of lysosomal enzymemia and, accordingly, a negative effect on the state of lysosomal membranes. Thus, FSH levels directly determined the concentrations of AP and cardiotropic cathepsin D. The levels of aDNAase in women with CHD of 56–65 years of age were positively correlated with indicators that determine insulin-­glucose homeostasis: glycemia (p<0.001), HOMA-IR index (p<0.001). Such associations of three marker lysosomal enzymes demonstrate the primary contribution of FSH ≥30 mIU/mL to an increase in the concentration of lysosomal hydrolases in women with CHD35–65 years old and the correlation of aDNAase with the processes triggered by insulin resistance