Male patients commencing FOLFOX / FOLFIRI chemotherapy in 2014, descriptive statistics

Background: Metastatic colorectal cancer is an incurable illness; however the advent of chemotherapy has significantly improved survival and symptom control. FOLFOX and FOLFIRI are used at SPBOH as the standard of care for patients with metastatic disease. No statistical data is available on that cohort of patients; this study aims to establish a population data-set for patients on FOLFOX/FOLFIRI. Methods: This retrospective cross-sectional study included all patients on FOLFOX and FOLFIRI in 2014. Only male patients were included, data was retrospectively extracted from the ward’s logbook and ISOFT clinical manager. Cycle 1, 6 and 12 dates were documented. Data was analysed using clinically reliable statistical tools, all reported p-values were statistically significant at <0.05. Results: From a total of 108 patients, 4 patients were excluded from the analysis. The average age of patients was 65.2 years. The average length of 12 cycles was 24.5 weeks. 19% of patients had cycles longer than 7 months whereas only 10% lasted more than 8 months on treatment. 41% of patients dropped out before completing the full course with a complication and mortality rate of 17%. Patients on FOLFIRI were more likely to have their chemotherapy changed and were also more likely to have received previous treatment. Conclusion: Although chemotherapy increases survival in metastatic colorectal cancer we have to appreciate that many patients do not proceed smoothly with their treatment. Many of those patients are middle aged independent individuals, after-all the physician must draw the line at the appropriate time and focus on palliative care rather than continuing ineffectively with chemotherapy.peer-reviewe

Experimental research into the effect of some operation factors and rock properties on the rate of penetration

Purpose. The purpose of this research is to investigate the effect of weight on bit (WOB), rotary speed (RPM), and some rock properties on the rate of penetration (ROP). Methods. Four types of rock were collected from different sites in the south of Egypt (Aswan sandstone, Isawya limestone, Assiut limestone, and Minya marble). These tested samples were drilled by diamond core bit using a fixed laboratory diamond drilling machine under conditions (400 and 1200 rpm), and loads from 12 to 220 kg. WOB, ROP, torque (T) and specific energy (SE) were continuously observed during the drilling trials. The effect of these factors on ROP were examined. Water is used as a flushing and cooling medium. Findings. The effect of some operation factors on the penetration rate regarding mineral composition and different rock type was evaluated and the general equation was carried out to predict the suitable operation factor which gives the best penetration Rate. Originality. The effect of some operation factors on the penetration rate regarding mineral composition and different rock type was evaluated and the general equation was carried out to predict the suitable operation factor which gives the best penetration Rate. Practical implications. The Results demonstrated that ROP was inversely proportional to compressive strength (CS), tensile strength (TS), and density. It was also found that Aswan sandstone, Isawya limestone, Assiut limestone, and Minya marble have CS 111.94 MPa, 131.22 MPa, 125.0 MPa, and 502.5 MPa respectively. Was established that ROP was directly proportional to porosity. Increasing ROP in case of Aswan sandstone is associated with increase in porosity – 23.158%, and in case of Assiut limestone and Isawya limestone ROP is also associated with an increase in porosity – 19.9% and 17.93% respectively. Decreasing ROP in case of Minya marble is associated with decrease in porosity – 2.314%. So, we concluded that marble has lower ROP due to its higher CS, TS, and density and lower porosity than other tested rocks.Мета. Вивчення впливу комплексу основних експлуатаційних параметрів і ряду фізико-механічних властивостей порід на швидкість буріння в умовах різних родовищ Південного Єгипту. Методика. Були відібрані 4 типи порід з різних районів на півдні Єгипту (Асуанської піщаник, вапняк Ісав, Ассіутскій вапняк і мармур Міньї). Експериментальні зразки отримано на стаціонарній лабораторній буровій установці з алмазним долотом при швидкостях обертання 400 і 1200 об/хв та при навантаженнях від 12 до 220 кг. Під час експериментів постійно вимірювалися навантаження на долото, частота обертання, крутний момент на долоті й питома енергія, а також досліджувався вплив цих факторів на швидкість буріння. Як розчин для промивання і охолоджуючий агент використовувалася вода. Результати. Встановлено залежності швидкості буріння від навантаження на долото, питомої енергії та частоти обертання і питомої енергії. Виявлено, що для всіх чотирьох типів породи швидкість буріння збільшується з ростом навантаження на долото, в той час як питома енергія зменшується з ростом швидкості буріння. Розроблено ефективний спосіб прогнозування продуктивності бурової установки. Встановлено, що швидкість буріння обернено пропорційна міцності на стиск, міцності на розтягнення й щільності, а також змінюється прямо пропорційно пористості. Визначено, що менша швидкість буріння мармуру пов’язана з великими значеннями міцності на стиск, розтяг і щільність, а також з меншою пористістю у порівнянні з іншими досліджуваними породами. Наукова новизна. Встановлено нові закономірності взаємозв’язку експлуатаційних параметрів буріння з урахуванням різного типу породи (пісковик, вапняк, мармур) та її мінерального складу, а також обґрунтовано головну умову експлуатаційного фактору, який забезпечує оптимальну швидкість буріння. Практична значимість. Отримані результати дозволяють вибирати оптимальні параметри і режими буріння в процесі розвідки умов залягання родовищ Південного Єгипту, їх мінерального вмісту та стратиграфічних особливостей. Результати будуть корисними для проектних організацій, наукових інститутів з геології й розвідки, а також гірничих підприємств.Цель. Изучение влияния комплекса основных эксплуатационных параметров и ряда физико-механических свойств пород на скорость бурения в условиях пород различных месторождений Южного Египта. Методика. Были отобраны 4 типа пород из различных районов на юге Египта (Асуанский песчаник, известняк Исавии, Ассиутский известняк и мрамор Миньи). Экспериментальные образцы получены на стационарной лабораторной буровой установке с алмазным долотом при скоростях вращения 400 и 1200 об/мин и при нагрузках от 12 до 220 кг. Во время экспериментов постоянно измерялись нагрузки на долото, частота вращения, крутящий момент на долоте и удельная энергия, а также и исследовалось влияние этих факторов на скорость бурения. В качестве промывочного раствора и охлаждающего агента использовалась вода. Результаты. Установлены зависимости скорости бурения от нагрузки на долото, удельной энергии и частоты вращения и удельной энергии. Выявлено, что для всех четырех типов породы скорость бурения увеличивается с ростом нагрузки на долото, в то время как удельная энергия уменьшается с ростом скорости бурения. Разработан эффективный способ прогнозирования производительности буровой установки. Установлено, что скорость бурения обратно пропорциональна прочности на сжатие, прочности на растяжение и плотности, а также изменяется прямо пропорционально пористости. Определено, что меньшая скорости бурения мрамора связана с большими значениями прочности на сжатие, растяжение и плотности, а также с меньшей пористостью по сравнению с другими исследуемыми породами. Научная новизна. Получены новые закономерности взаимосвязи эксплуатационных параметров бурения с учетом различного типа породы (песчаник, известняк, мрамор) и ее минерального состава, а также обосновано главное условие эксплуатационного фактора, который обеспечивает оптимальную скорость бурения. Практическая значимость. Полученные результаты позволяют выбирать оптимальные параметры и режимы бурения в процессе разведки условий залегания месторождений Южного Египта, их минерального содержание и стратиграфических особенностей. Результаты будут полезными для проектных организаций, научных институтов по геологии и разведке, а также горных предприятий.Our sincere gratitude for Mining and Metallurgical Engineering Dept. Faculty of Engineering, Assiut, Egypt for invaluable assistance to upgrade and guidance to completed this article

Studying the Dynamical Properties of 20 Nearby Galaxy Clusters

Using SDSS-DR7, we construct a sample of 42382 galaxies with redshifts in the region of 20 galaxy clusters. Using two successive iterative methods, the adaptive kernel method and the spherical infall model, we obtained 3396 galaxies as members belonging to the studied sample. The 2D projected map for the distribution of the clusters members is introduced using the 2D adaptive kernel method to get the clusters centers. The cumulative surface number density profile for each cluster is fitted well with the generalized King model. The core radii of the clusters' sample are found to vary from 0.18 Mpc \mbox{h}^{-1} (A1459) to 0.47 Mpc \mbox{h}^{-1} (A2670) with mean value of 0.295 Mpc \mbox{h}^{-1}. The infall velocity profile is determined using two different models, Yahil approximation and Praton model. Yahil approximation is matched with the distribution of galaxies only in the outskirts (infall regions) of many clusters of the sample, while it is not matched with the distribution within the inner core of the clusters. Both Yahil approximation and Praton model are matched together in the infall region for about 9 clusters in the sample but they are completely unmatched for the clusters characterized by high central density. For these cluster, Yahil approximation is not matched with the distribution of galaxies, while Praton model can describe well the infall pattern of such clusters.Comment: 16 pages, 8 figure

The Effect of Chronic Traumatic Experience on Palestinian Children in the Gaza Strip

Abstract In this research, two studies were conducted in order to examine the psychological, social, somatic and educational effects of chronic traumatic experience on Palestinian children over the six years of the Al-Aqsa Intifada (2000-2006). Firstly, a quantitative study was conducted which aimed to explore the long-term effects of war and occupation on the Palestinian children in the Gaza Strip. The sample consisted of 1,137 children aged between ten and 18 years randomly selected from all parts of the Gaza Strip to participate in the study. The participants completed a Checklist of Traumatic Experiences (CTE), a Symptoms of Post Traumatic Stress Disorder Scale (SPTSDS), a Network of Psycho-Social Support (NPSS) and a Personality Assessment Questionnaire (PAQ). This study found that every child in Palestine is likely to have been exposed to at least three traumatic events. Importantly, this study also found that 41% of the participants suffered from Post-Traumatic Stress Disorders (PTSD). This indicates that there are potentially more than 300,000 children in the Gaza Strip in need of psychological, social,and medical services in the areas of rehabilitation and therapeutic treatment. The study revealed that the support of family, friends, relatives, teachers, and spiritual leaders can be of great help. In addition to this, positive traits of personality can reduce the effects of PTSD. Secondly, a qualitative study aimed to explore, in more depth, the moderating factors relating to Palestinian children who have been exposed to chronic traumatic experiences, particularly the children who show low levels of PTSD. The sample consisted of six children interviewed in Arabic by using a semi-structured interview. They were aged between 13-18 years. The participants were selected according to the amount of traumatic events and level of PTSD experienced by the children who took part in the first study. This study found that the moderating factors and levels of influence which protected them from developing PTSD are positive personality traits and ideological commitment, psychosocial support, entertainment and adaptation or acclimatization. This research concluded that having a normal childhood in Palestine is unlikely in the current circumstances and the future psychological well-being of Palestinian children is at risk of being compromised by on-going traumatic experiences

Dead code elimination based pointer analysis for multithreaded programs

This paper presents a new approach for optimizing multitheaded programs with pointer constructs. The approach has applications in the area of certified code (proof-carrying code) where a justification or a proof for the correctness of each optimization is required. The optimization meant here is that of dead code elimination. Towards optimizing multithreaded programs the paper presents a new operational semantics for parallel constructs like join-fork constructs, parallel loops, and conditionally spawned threads. The paper also presents a novel type system for flow-sensitive pointer analysis of multithreaded programs. This type system is extended to obtain a new type system for live-variables analysis of multithreaded programs. The live-variables type system is extended to build the third novel type system, proposed in this paper, which carries the optimization of dead code elimination. The justification mentioned above takes the form of type derivation in our approach.Comment: 19 page