A search for disordered (glassy) phase in solid 3He deformed in situ

A disordered (glassy) state has been searched in solid 3He deformed in the course of experiment employing precise measurements of pressure. The analysis of the temperature dependence of the crystal pressure measured at a constant volume shows that the main contribution to the pressure is made by the phonon subsystem, the influence of the disordered phase being very weak. Annealing of the deformed crystal does not affect this state. The results obtained differ greatly from the corresponding data for solid 4He measured in the region of supersolid effects where a pressure excessive in comparison to the phonon one was registered. The excess pressure had a quadratic dependence on temperature, which is typical of a disordered system. Absence of the excess pressure in solid 3He is unclear yet, some speculative interpretations are suggested.Comment: 9 pages, 4 figure

Mechanisms of hopping conductivity of p-CdSb:Ni in magnetic field

Hopping conductivity in single crystals of the group II-V ani-sotropic diluted magnetic semiconductor p-CdSb:Ni, oriented along the [100] (# 1), [010] (# 2) and [001] (# 3) axes, is in-vestigated in zero and pulsed magnetic fields B. At B= 0 the Mott variable-range hopping (VRH) conductivity is observed in # 2, and the Shklovskii-Efros VRH conductivity in # 1 and # 3 at T ≤2.5 K. However, in weak fields of B < 6 T tempera-ture dependence of the resistivity gives evidence for the Mott VRH conductivity in # 1 below ~ 4.2 K, whereas in # 2 and # 3 the nearest-neighbour hopping (NNH) conductivity is ob-served between 3−4.2 K and between 1.5−4.2 K, respectively. Eventually, in high magnetic fields of Bup to ~ 15 T and T ≤ 4.2 K only the NNH conductivity is observed in all investi-gated samples. The analysis of the resistivity data yields the set of microscopic parameters, such as the localization radius, the widths of the Coulomb gap and of the impurity band, the density of the localized states and the anisotropy coefficients, as well as the values of the acceptor concentration and the di-electric permittivityyesBelgorod State Universit

Hopping conductivity of Ni-doped p-CdSb

From the experimental data the values of the localization radius and dielectric permittivity and details of their critical behavior near the metal-insulator transition, as well as the widths and the values of the density of the localized states, the acceptor energies, their concentrations and the anisotropy coefficients, are obtainedyesBelgorod State Universit

Magnetic properties of CdSb doped with Ni

Magnetic properties of the group II-V semiconductor CdSb single crystals doped with Ni (2at%) are investigatedyesBelgorod State Universit

Low-field magnetic properties of La₁-xSrxMn₁-yFeyO₃

The low-field magnetic properties above can be explained by the phase separation effect or generation of nanosize FM particles in the paramagnetic host matrix of LSMFOyesBelgorod State Universit

Phase separation, ferromagnetism and magnetic irreversibility in La1-xSrxMn1-yFeyO3

The ferromagnetism of LSMFO is attributable to percolation over the system of such particles and generation of large FM clusters, whereas the frustration is governed presumably by a system of smaller weakly-correlated magnetic units, which do not enter the percolative FM clustersyesBelgorod State Universit

Disorder in (Zn₁₋ₓMnₓ)₃As₂ and its consequences on impurity conduction and magnetic properties

Special attention is paid to the remanent disorder at temperatures much below the order-disorder phase hansition temperature Tph. Dependences of Tph and the activation energy of hopping conductivity on composition are analysedyesBelgorod State Universit

NMR screening of potential inhibitors of methionine γ-lyase from Citrobacter freundii

© 2014, Pleiades Publishing, Inc. Methionine γ-lyase [EC 4.4.1.11] participates in methionine catabolism in a number of bacteria and protozoa eukaryotes, including pathogenic microorganisms. The lack of this enzyme in mammals allows us consider it to be a promising target for rational antibacterial drug design. Currently, in medical practice, there are no preparations based on the inhibition of methionine γ-lyase. We present the results of a search for potential inhibitors of this enzyme using NMR screening techniques based on the identification of compounds, which are able to bind specifically to their biological target. The study included a stage of in silico virtual screening of the library of commercially available compounds and subsequent experimental selection of the leading compounds capable to interact with the enzyme. The identification of binding was carried out using saturation transfer difference (STD) spectroscopy and the WaterLOGSY technique. During the final stage, an experimental assessment of the inhibition activity of the selected compounds in the reaction of the γ elimination of L-methionine catalyzed by methionine γ-lyase was performed. Binding constants of two leading compounds were determined using the WaterLOGSY method. This study expands the structural group of potential inhibitors of methionine γ-lyase and allows us to approach the design of its inhibitors with higher efficacy