PROLONGED THERAPY WET FORM OF AGE-RELATED MACULAR DEGENERATION BY THE INTRODUCTION OF BEVACIZUMAB ON THE VISCOUS MEDIA IN SUBTENON SPACE (PRELIMINARY RESULTS)

Purpose: To evaluate the clinical clinical application subtenon administration of bevacizumab on the viscous media with the purpose of strengthening and prolong of therapeutic effect in the treatment of wet form of age-related macular degeneration (AMD).Materials and Methods: The study included 6 patients (6 eyes) with the wet form of AMD, who underwent the introduction of bevacizumab at a dose of 5 mg (0.2 ml) into the back subtenon space for viscous media – hydroxypropylmethylcellulose (the patent application on the invention of the Russian Federation №2013105697 from 11.02.2013). All patients underwent visometry, biomicroscopy, ophthalmoscopy, fundus photographic recording, optical coherence tomography and fluorescein angiography. The follow-up 3 months.Results: The mean values of visual acuity with correction improved after treatment (from 0.06 to 0.2). Central retinal thickness average decreased after treatment all patients (363.5 μm to 309 μm). Also, we have seen a significant decrease in transsudativnyh processes in the retina in all patients and reducing the suretinal of a neovascular membrane into 1.2 times, that speaks about supperession of activity choroidal neovascularization. The effect was observed throughout the period of observation.Summary: Subtenon introduction of bevacizumab is safe and has a positive effect in wet AMD, and its application to a viscous mediа has a prolonged effect

COVID-19-ассоциированный ангиит: обзор литературы и описание клинического случая

The article systematizes information about various dermatological signs of a novel coronavirus infection – COVID-19. Special attention is paid to the phenomenon of COVID-19-associated angiitis. A clinical case of acroischemia associated with COVID-19 is described: on the 34th day after the onset of infection, a patient developed skin cyanosis of the distal parts of the fingers, which resolved spontaneously after a few days. The need for further research on the skin manifestations of COVID-19 and the development of an effective strategy for managing patients, as well as monitoring the condition of convalescents, is emphasized.В статье систематизированы сведения о различных дерматологических признаках новой коронавирусной инфекции – COVID-19. Особое внимание уделено феномену COVID-19-ассоциированного ангиита. Описан клинический случай акроишемии, связанной с COVID-19: у пациента на 34-й день после дебюта инфекции развился цианоз кожи дистальных отделов пальцев кистей, разрешившийся самостоятельно через несколько дней. Подчеркивается необходимость дальнейших исследований кожных проявлений COVID-19 и разработки эффективной стратегии ведения пациентов, а также мониторинга состояния реконвалесцентов

ECOLOGICAL AND EPIDEMIOLOGICAL ASPECTS OF WEST NILE FEVER IN THE ROSTOV REGION

RETRACTEDPurpose: Th e study of the West Nile Fever (WNF) with the estimation of results of ecological/epizootological monitoring and epidemic manifestations of infection.Materials and methods: investigations for the presence of antigen of WN virus were carried out on 5754 specimen (4187 samples of brain suspensions) of birds belonging to 90 species, 15 orders; 4153 specimen (1038 samples of brain suspensions) of 17 species of mammals; 46113 specimen (2081) of 18 species of mosquitoes; 13883 specimen (1588) of imago ticks of six species, and others (2001-2013). Methods used: enzyme-linked immunosorbent assay, epidemiological analysis.Results: the territories of risk for WNF were defi ned with regard to bird ecology, fauna of mosquitoes of Culicidae family was characterized, the ecological linkages of WN virus with birds, mosquitoes and mammals were defi ned. Th e area of habitation of West Nile (WN) virus was determined. Epizootological/epidemiological zoning of the Rostov Region was carried out with identifi cation of territories, diff ering by the degree of risk of population infection with WN virus.Summary: Th e results obtained can serve the evidence of formation of natural and anthropurgic foci of WNF

West Nile Fever in the Rostov Region: Ecological and Epidemiological Peculiarities of the Outbreak in 2010

This paper describes the outbreak of West Nile fever in the Rostov Region in 2010 and evaluates its ecological and epidemiological peculiarities. From 15th of July till 22nd of September 2010, detected were the 64 cases (1, 4800/0000) of the disease, which were characterized by vector-born mechanism of transmission. Peak of morbidity coincided with mass breeding of Culicidae, increase in the number of Culex mosquitoes, and reoccurring growth of Aedes mosquito population. Diffuse type of the epidemiological process, higher rates of the cases among urbanites, infected in the country-side area, were the characteristic features of that outbreak. West Nile virus antigen was detected by means of IFA in samples taken from An. maculipennis and Cx. pipiens mosquitoes, wild and synanthropic birds, Rh. rossicus ticks, house and wood mice, which facilitates identification of the core factors for the agent circulation and West Nile fever natural focus formation