The notion of «competence» and «competentia» in the theory of the formation of professional and pedagogical competence of the future teachers of higher agricultural education institution.

The foundation for the professional and pedagogical competence of the future teachers of higher agricultural education at the present stage of development of higher education is based on the competence approach. Analysis of the essence of the concepts of «competence» and «competentia» in psycho-pedagogical literature gives us a clear idea about the differences between them and their structure.В основу формирования профессионально-педагогической компетентности будущего преподавателя высшего аграрного учебного заведения на современном этапе развития высшего образования положен копетентностный подход. Анализ сущности понятий «компетентность» и «компетенции» в психолого-педагогической литературе даёт нам чёткое представление об отличиях между ними и их структуре

Experimental investigations of the vortex-chain generated in the two-component plasma with the sheared flow of magnetized electrons

We present further experimental results on the observation of electron vortices in an electrostatic plasma lens at the strong radial gradient of electron density. Anharmonic low frequency large-amplitude potential waves propagating in azimuth direction are observed. The recently observed results give additional confirmation that the observed waves are the manifestation of the vortex-chain generated at the azimuthal sheared flow of magnetized electrons compensating ion beam

Positional Cloning of cobblestone, a Mouse Mutant Showing Major Defects in Brain Development, Identifies Ift88 as a Candidate Gene

The ENU-induced cobblestone (cbs) mouse mutant exhibits severe defects in fore- and midbrain development. Via genomic mapping, the causative mutation for the cbs-phenotype has previously been located on chromosome 14 in the proximity of the gene Ift88 (Intraflagellar transport, 88 kDa). The Ift88 protein is involved in intraflagellar transport and is required for genesis and maintenance of primary and motile cilia. In order to refine the genetic interval further, we performed fine-mapping analysis of the cbs mutant. The candidate region of the cbs mutation is shown to be situated in a region of 4.14 Mb on chromosome 14, containing the Ift88 gene, and excluding dozens of genes present in the roughly-mapped interval. However, neither sequencing of the core Ift88 promoter region nor of two conserved intronic sequences within Ift88 revealed any mutations, indicating that the responsible mutation lies in a transcriptional regulatory sequence within or near the Ift88 gene. Finally, other potential candidate genes in this genetic interval have been identified using synteny analysis on six other vertebrate genomes. This analysis is thus compatible with the idea that the mutation in cbs is located on the Ift88 gene, but it also allows the possibility of other candidate genes that lie near Ift88 to be involved in the phenotype

Display of Protectionism in Modern Tourist Branch

The necessity to protect the interests of the Russian Federation in the context of an aggressive sanctions situation determine the need to take protecting measures for the domestic market and its consumers. The research analyzes key economic and political developments that have affected to stability and structure both inbound and outbound tourist flow. Measures taken to stabilize and strengthen domestic tourism are observed. The issue of rationality of measures aimed at increasing the domestic tourism volume from the import substitution point of view are also raised

Definition of Groups of Social Tourism Subjects

The article is aimed to analyze meaning of «social tourism». The importance of social tourism as a mechanism providing the opportunity  to make travel and recreation accessible to all segments of the  population is observed. In this regard, beside economic aspects of social tourism the article is also dealt with ethical aspects. The issue of  classifying groups of people, who needs support in performing their  right for the rest, for most efficient leisure and efficient allocation of  financial resources and time, is being raised

Intellectual assessment of staff sufficiency for innovative development of the sustainable regional agro-industrial complex

The paper is devoted to the problems of assessment of staff sufficiency for regional economy agroindustrial sector’s innovative development. The proposed approach is based on the application of models and methods of expert assessment and digital intelligent technologie

Скрининг депрессии с оценкой социально-экономического статуса пациентов в первичной медицинской сети в крупном промышленном центре Восточной Сибири

The aim was to compare the relationship between the severity of depression symptoms among the unorganized population of Krasnoyarsk in 2006 and 2012 with respect to socioeconomic and demographic factors; and to compare their prevalence for the analyzed period.Materials and methods. Two sample groups were selected from the unorganized population that resided permanently in the territory of Krasnoyarsk in 2006 and 2012. Evaluation of the severity of depression in both cases was carried out according to the Hospital Anxiety and Depression Scale, Depression subscale (HADS-D). Results. In both sample groups, the frequency of depression was associated with age. In 2012, social and economic factors of depression were revealed: lack of higher education, widowhood, unemployment and family poverty. A significant decrease in the frequency of increased (39.1% vs 16.4%) and clinical depression (14.6% vs 4.5%) was found for the period from 2006 to 2012. Conclusions. In 2012, the frequency of the above-normal depression level according to HADS-D in working age population was largely determined by the influence of socioeconomic factors. A decrease in the frequency of increased and clinical levels of depression among the adult population of Krasnoyarsk over the period from 2006 to 2012 was established.Цель. Оценить взаимосвязь выраженности симптомов депрессии по Госпитальной шкале тревоги и депрессии HADS (The Hospital Anxiety and Depression Scale; подшкала HADS(d)) среди неорганизованного населения г. Красноярска в 2006 и 2012 гг. с социально-экономическими и демографическими факторами, а также сопоставить их распространенности за анализируемый период.Материалы и методы. Обследованы две выборки, сформированные из неорганизованного населения, постоянно проживавшего на территории г. Красноярска в 2006 и 2012 гг. Оценка выраженности симптомов депрессии в обоих случаях проводилась согласно HADS(d).Результаты. В обеих выборках отмечена связь частоты симптомов депрессии с возрастом. В 2012 г. выявлены социальные и экономические факторы депрессии: отсутствие высшего образования, вдовство, безработица и бедность семьи. Установлено значимое снижение частоты повышенной (39,1 против 16,4%) и клинической депрессии (14,6 против 4,5%) за период с 2006 по 2012 г.Заключение. В 2012 г. частота уровня депрессии «выше нормы» по HADS(d) в трудоспособном возрасте во многом обусловлена влиянием социально-экономических факторов. Установлено снижение частоты повышенного и клинического уровня депрессии по HADS(d) среди взрослого населения г. Красноярска за период с 2006 по 2012 г

Analytical “Bake-Off” of Whole Genome Sequencing Quality for the Genome Russia Project Using a Small Cohort for Autoimmune Hepatitis

A comparative analysis of whole genome sequencing (WGS) and genotype calling was initiated for ten human genome samples sequenced by St. Petersburg State University Peterhof Sequencing Center and by three commercial sequencing centers outside of Russia. The sequence quality, efficiency of DNA variant and genotype calling were compared with each other and with DNA microarrays for each of ten study subjects. We assessed calling of SNPs, indels, copy number variation, and the speed of WGS throughput promised. Twenty separate QC analyses showed high similarities among the sequence quality and called genotypes. The ten genomes tested by the centers included eight American patients afflicted with autoimmune hepatitis (AIH), plus one case’s unaffected parents, in a prelude to discovering genetic influences in this rare disease of unknown etiology. The detailed internal replication and parallel analyses allowed the observation of two of eight AIH cases carrying a rare allele genotype for a previously described AIH-associated gene (FTCD), plus multiple occurrences of known HLA-DRB1 alleles associated with AIH (HLA-DRB1-03:01:01, 13:01:01 and 7:01:01). We also list putative SNVs in other genes as suggestive in AIH influence

Genome-wide sequence analyses of ethnic populations across Russia

The Russian Federation is the largest and one of the most ethnically diverse countries in the world, however no centralized reference database of genetic variation exists to date. Such data are crucial for medical genetics and essential for studying population history. The Genome Russia Project aims at filling this gap by performing whole genome sequencing and analysis of peoples of the Russian Federation. Here we report the characterization of genome-wide variation of 264 healthy adults, including 60 newly sequenced samples. People of Russia carry known and novel genetic variants of adaptive, clinical and functional consequence that in many cases show allele frequency divergence from neighboring populations. Population genetics analyses revealed six phylogeographic partitions among indigenous ethnicities corresponding to their geographic locales. This study presents a characterization of population-specific genomic variation in Russia with results important for medical genetics and for understanding the dynamic population history of the world's largest country

COVID-19-ассоциированный бивентрикулярный синдром Такоцубо, осложнившийся кардиогенным шоком (клиническое наблюдение)

Acute myocardial dysfunction (AMD) remains prominent among extrapulmonary manifestations of COVID-19. Takotsubo syndrome (TS) is one of the causes of AMD development. TS incidence in patients with COVID-19 is currently unknown. The report presents a clinical case of an elderly female patient on maintenance hemodialysis with severe COVID-19. During the session of therapeutic plasma exchange (TPE), the patient had an episode of ventricular fibrillation followed by cardiogenic shock development and ECG changes, similar to myocardial infarction. Echocardiographic (Echo) data showed a distinctive pattern of biventricular TS with a significant systolic function decrease in both ventricles. Emergency CT angiography ruled out obstructive lesions of coronary arteries. Full recovery of both ventricles systolic function, regression of ECG changes, and complete resolution of cardiogenic shock were observed within the next week. The subsequent course of the disease was complicated by sepsis and multiple organ failure which determined the lethal outcome.The autopsy findings excluded coronarogenic and viral myocardial damage. The presented case demonstrates a life-threatening TS pattern in patients with severe COVID-19. TPE procedure should be treated as a possible trigger of TS.Среди внелегочных проявлений COVID-19 важное место занимает острая миокардиальная дисфункция. Одной из причин ее развития является синдром Такоцубо (СТ). Частота встречаемости СТ у пациентов с COVID-19 неизвестна. Представлено клиническое наблюдение пожилой пациентки с тяжелым течением COVID-19, получавшей лечение программным гемодиализом. В ходе сеанса терапевтического плазмообмена развился эпизод фибрилляции желудочков с формированием клинико-инструментальной картины кардиогенного шока, сопровождавшейся инфарктоподобными изменениями ЭКГ. По данным Эхо-КГ выявлен типичный паттерн бивентрикулярного СТ с выраженным снижением систолической функции обоих желудочков. По результатам экстренной коронароангиографии обструктивного поражения коронарного русла не выявлено. В течение последующей недели лечения отмечались полное восстановление систолической функции обоих желудочков, регресс инфарктоподобных изменений ЭКГ и разрешение кардиогенного шока. Дальнейшее течение заболевания осложнилось развитием сепсиса и полиорганной недостаточности, приведших к летальному исходу. По данным аутопсии коронарогенное и вирусное поражение миокарда были исключены.Представленный случай демонстрирует развитие жизнеугрожающего варианта СТ у пациентки с COVID-19. В качестве вероятного триггера следует рассматривать процедуру терапевтического плазмообмена