CORRECTION OF FEMUR DEFORMITIES BY ILIZAROV METHOD AND BY APPARATUS «ORTHO-SUV» BASED ON COMPUTER NAVIGATION

Results of correction of femur deformations by Ilizarov method and with apparatus Orto-SuV working on the basis of computer navigation are analyzed. For elimination of difficult deformations in order to avoid multiple external fixator remounting with stage-by-stage radiological control it is expedient to use apparatus Orto-SUV. In order to elimination of moderate and simple deformations (except torsion) as hexapods and traditional techniques can be a choice method. The use «Orto-SUV» apparatus allows to reduce time necessary for deformation correction and osteosynthesis term in 1,4–2,4 times (for average and severe deformations)

OPTIMIZATION OF THE ORTHO-SUV FRAME ASSEMBLY FOR CORRECTION OF THE DISTAL FEMUR DEFORMITIES

The aim of the study was to investigate optimal assembly of the computer assisted Ortho-SUV Frame for correction of the distal femur deformities which will provide the maximal bone fragments mutual movements and have the minimal assembly sizes. For it 360 bench tests on 12 model was performed. The dependence of the Ortho-SUV Frame reduction capabilities (translation, angulation, torsion) and distance between supports, places of struts fixation and use of Z-shaped plates for struts fixation was investigated. It is found that in Ortho-SUV assembling to provide the necessary requirements 3/4 ring supports is reasonable. Distal support should be placed at the level VII, proximal at the distance 150–200 mm higher. For fixation of the strut 1 to the proximal support position 2 should be used, for the strut 3 – the place between position 5 and 6, for strut 5 – position 10; for fixation of the strut 2 to the distal support position 4 should be used, for fixation of the strut 4 – position 8, for strut 6 – position 12. Use of the Z-shaped plates in fixation of strut 1 and 5 increases the reduction capabilities on 11.4–25.5% in average. Use of modular transformation of the frame allows decreasing the bulkiness of the frame after deformity correction. Investigated assembly was applied in treatment of 14 patients. In all the cases the aim of Ortho-SUV frame use (deformity correction) was reached

Determination of the Maximal Corrective Ability and Optimal Placement of the Ortho-SUV Frame for Femoral Deformity with respect to the Soft Tissue Envelope, a Biomechanical Modelling Study

Circular fixation according to the Ilizarov method is a well-recognised modality of treatment for trauma and deformity. One shortcoming of the traditional fixator is its limited ability to correct more than one plane of deformity simultaneously, leading to lengthy frame-time indices. Hexapod circular fixation utilising computer guidance is commonplace for complex multidimensional deformity but difficulties often arise with correction of femoral deformity due to bulkiness of the frame construct, particularly in proximal deformity and in patients of increased size. The Ortho-SUV frame is an innovative hexapod which permits unique customisation to individual patient anatomy to maximise tolerance and optimal range of deformity correction. We hypothesised that the optimal configuration and maximal degree of correction achievable by the Ortho-SUV frame can be biomechanically modelled and applied clinically. A study was constructed using Ortho-SUV and femoral limb models to measure deformity correction via differing frame constructs and determine optimal frame configuration to achieve correction in proximal, middle, and distal third deformities with respect to the soft tissue envelope. The ideal frame configuration is determined for correction of deformity in all locations of the femur with the maximal parameters of correction calculated whilst avoiding and mitigating soft tissue irritation from bulky frame construction

Protective Effects of Selenopyran Against Carbon Tetrachloride Hepatotoxicity in Rats

Carbon tetrachloride (CCl4) is a known hepatotoxic compound working through the generation of reactive free radicals. Selenium (Se) is an essential trace element required by animals and humans for protection against xenobiotic compounds. In this study, Se, as selenopyran, has been evaluated for its protective action against CCl4-induced hepatotoxicity in Wistar rats. CCl4 exerts its toxic effects by generation of free radicals; it was intraperitoneally administered to male Wistar rats (2g/kg body weight) 24 h before the animals were decapitated. Selenopyran (2mg/kg body weight) was administered intragastrically one month before CCl4 injection. Rats injected with CCl4 alone showed significant lipid and hydropic dystrophy of liver, massive necrosis of hepatocytes, increases in free and conjugated bilirubin levels were marked as well as elevation of hepatic enzymes (alanine aminotransferase and aspartate aminotransferase) in plasma. Selenopyran administered at a pharmacological dose diminished the toxic effects of CCl4. Thus it decreased both the structural and functional injury of hepatocytes and clearly exerted hepatoprotective effects. These findings suggest that the effect of selenopyran on CCl4-induced acute liver injury depends on the antioxidant action Se

Protective Effects of Selenopyran Against Carbon Tetrachloride Hepatotoxicity in Rats

Protective Effects of Selenopyran Against Carbon Tetrachloride Hepatotoxicity in Rats</p