Apport de la mesure de la pression artérielle centrale ambulatoire dans la caractérisation phénotypique de la démence de type Alzheimer

Dans les pays développés, la prévalence des démences est de 5% chez les plus de 65ans et doublerait pour chaque tranche d'âge de 10 ans. Avec le vieillissement de la population, le nombre de personnes atteintes de démence augmente chaque année, ce qui pose le problème de trouver rapidement des thérapies et mesures de prévention efficaces. Il est connu que l'hypertension artérielle (HTA) est un facteur de risque pour certaines démences. De plus, de récentes études démontrent que la pression artérielle centrale serait un marqueur hémodynamique plus représentatif des lésions causées au cerveau, dues à une HTA, que la pression périphérique usuellement mesurée. Il serait donc intéressant d'évaluer si la démence est associée à une augmentation de la pression artérielle centrale, en comparaison avec des patients hypertendus non déments. But de l'étude : Cette étude a pour but de quantifier l'apport de la mesure de la pression artérielle centrale ambulatoire dans la caractérisation des patients avec une démence de type Alzheimer. L'objectif principal est de déterminer la taille de la différence de pression artérielle centrale et son écart-­‐type entre les patients hypertendus avec ou sans démence de type Alzheimer afin de pouvoir calculer le nombre de patients nécessaire pour montrer une différence significative. Dans cette étude, nous allons tester l'hypothèse que la pression artérielle centrale (moyenne, systolique et diastolique) est plus élevée chez les patients atteints de troubles cognitifs et/ou qu'ils présentent des perturbations du rythme circadien plus marquées, notamment pour les valeurs durant le sommeil, (non-­‐dipping, reverse dipping, extreme dipping)

Broadening of hot-spot response spectrum of superconducting NbN nanowire single-photon detector with reduced nitrogen content

The spectral detection efficiency and the dark count rate of superconducting nanowire single-photon detectors (SNSPD) has been studied systematically on detectors made from thin NbN films with different chemical compositions. Reduction of the nitrogen content in the 4 nm thick NbN films results in a more than two orders of magnitude decrease of the dark count rates and in a red shift of the cut-off wavelength of the hot-spot SNSPD response. The observed phenomena are explained by an improvement of uniformity of NbN films that has been confirmed by a decrease of resistivity and an increase of the ratio of the measured critical current to the depairing current. The latter factor is considered as the most crucial for both the cut-off wavelength and the dark count rates of SNSPD. Based on our results we propose a set of criteria for material properties to optimize SNSPD in the infrared spectral region.Comment: 15 pages, 6 figure

Invariant four-forms and symmetric pairs

We give criteria for real, complex and quaternionic representations to define s-representations, focusing on exceptional Lie algebras defined by spin representations. As applications, we obtain the classification of complex representations whose second exterior power is irreducible or has an irreducible summand of co-dimension one, and we give a conceptual computation-free argument for the construction of the exceptional Lie algebras of compact type.Comment: 16 pages [v2: references added, last section expanded

Small optic suspensions for Advanced LIGO input optics and other precision optical experiments

We report on the design and performance of small optic suspensions developed to suppress seismic motion of out-of-cavity optics in the Input Optics subsystem of the Advanced LIGO interferometric gravitational wave detector. These compact single stage suspensions provide isolation in all six degrees of freedom of the optic, local sensing and actuation in three of them, and passive damping for the other three

Hamiltonian reductions of free particles under polar actions of compact Lie groups

Classical and quantum Hamiltonian reductions of free geodesic systems of complete Riemannian manifolds are investigated. The reduced systems are described under the assumption that the underlying compact symmetry group acts in a polar manner in the sense that there exist regularly embedded, closed, connected submanifolds meeting all orbits orthogonally in the configuration space. Hyperpolar actions on Lie groups and on symmetric spaces lead to families of integrable systems of spin Calogero-Sutherland type.Comment: 15 pages, minor correction and updated references in v

Polar foliations and isoparametric maps

A singular Riemannian foliation $F$ on a complete Riemannian manifold $M$ is called a polar foliation if, for each regular point $p$, there is an immersed submanifold $\Sigma$, called section, that passes through $p$ and that meets all the leaves and always perpendicularly. A typical example of a polar foliation is the partition of $M$ into the orbits of a polar action, i.e., an isometric action with sections. In this work we prove that the leaves of $F$ coincide with the level sets of a smooth map $H: M\to \Sigma$ if $M$ is simply connected. In particular, we have that the orbits of a polar action on a simply connected space are level sets of an isoparametric map. This result extends previous results due to the author and Gorodski, Heintze, Liu and Olmos, Carter and West, and Terng.Comment: 9 pages; The final publication is available at springerlink.com http://www.springerlink.com/content/c72g4q5350g513n1

Ensuring Secure Non-interference of Programs by Game Semantics

Non-interference is a security property which states that improper information leakages due to direct and indirect flows have not occurred through executing programs. In this paper we investigate a game semantics based formulation ofnon-interference that allows to perform a security analysis of closed and open procedural programs. We show that such formulation is amenable to automated verification techniques. The practicality of this method is illustrated by several examples, which also emphasize its advantage compared to known operational methods for reasoning about open programs.<br/

Overview of Advanced LIGO Adaptive Optics

This is an overview of the adaptive optics used in Advanced LIGO (aLIGO), known as the thermal compensation system (TCS). The thermal compensation system was designed to minimize thermally-induced spatial distortions in the interferometer optical modes and to provide some correction for static curvature errors in the core optics of aLIGO. The TCS is comprised of ring heater actuators, spatially tunable CO$_{2}$ laser projectors and Hartmann wavefront sensors. The system meets the requirements of correcting for nominal distortion in Advanced LIGO to a maximum residual error of 5.4nm, weighted across the laser beam, for up to 125W of laser input power into the interferometer

Experimental Study of the Radiative Decays K+ -> mu+ nu e+e- and K+ -> e+ nu e+e-

Experiment 865 at the Brookhaven AGS obtained 410 K+ -> e+ nu e+e- and 2679 K+ -> mu+ nu e+e- events including 10% and 19% background. The branching ratios were measured to be (2.48+-0.14(stat.)+-0.14(syst.))x10^-8 (m_ee>150 MeV) and (7.06+-0.16+-0.26)x10^-8 (m_ee>145 MeV), respectively. Results for the decay form factors are presented.Comment: 4 pages, 3 figures, RevTeX

Brownian bridges to submanifolds

We introduce and study Brownian bridges to submanifolds. Our method involves proving a general formula for the integral over a submanifold of the minimal heat kernel on a complete Riemannian manifold. We use the formula to derive lower bounds, an asymptotic relation and derivative estimates. We also see a connection to hypersurface local time. This work is motivated by the desire to extend the analysis of path and loop spaces to measures on paths which terminate on a submanifold