Metastases to the Thyroid Presenting as a Metabolically Inactive Incidental Thyroid Nodule with Stable Size in 15 Months

Though the thyroid gland has a rich vascular supply, incidence of metastatic disease from distant organs is rare. Here we present an unusual case of metastases to the thyroid with several interesting features. A 63-year-old male with history of adenocarcinoma of the right lobe lung (5 years prior to presentation), treated with surgery and chemotherapy, followed by new adenosquamous lung cancer in the left lobe of the lung (one year prior to presentation), treated surgically followed by adjuvant chemotherapy, was referred to Endocrinology section for evaluation of an incidental thyroid nodule on CT chest. Ultrasound (US) of the thyroid revealed a complex, predominantly hypoechoic lesion measuring 1.8 cm within the lower pole of the right thyroid lobe and a subcentimeter lesion in the left lobe of the thyroid. Review of prior CT chests showed that the lesion in the right lobe was stable for 15 months, with no evidence of a hypermetabolic lesion on PET scan. The subcentimeter lesion was not seen on prior CT scans. US guided fine needle aspiration (FNA) and pathology of the lobectomy of the thyroid confirmed adenosquamous carcinoma. Interesting features in this case are that the thyroid metastases occurred without any evidence of synchronous lesions elsewhere, the size was stable over 15 months, and the lesions were metabolically inactive

Design of Hybrid System Using Reflector for Isolated Areas

The project based on the concept of conservation of light energy from the lamps such as CFL ,Incandescent etc and using the reflector to reflect the light energy to PV panel .The lamps are the essential things that we have been using day to day life .The Solar cells act as the light absorber which will convert the light energy into the electrical energy along with this the wind turbine which convert the kinetic energy in the wind into mechanical power is used to produce hybrid power So from that we can generate more energy and store this in a battery. The hardware implementation, Design and analysis of the Power generation from the light energy emitted from the lamps has been made in this project .The Solar panel with the reflector where the performance development has been scrutinized. This Hybrid power generation method is a pioneering approach which will provide the backup power generation system at the time of power failure. Emergency Lamp, Fan and Battery charging has been used as a load in this project. The load will vary when amount of power generated is varied

Synthesis, Characterization, Insilico Studies, and Biological Evaluation of Novel Hybrid Chalcone Derivatives as Antibacterial Agents

All the designed compounds were subjected to molecular docking studies for structural and interaction information. Ciprofloxacin and all designed compound 3a-t were docked in the active site of DNA gyrase subunit B and Binding affinities was calculated. Compound 3b, 3d, 3f, 3j and 3r had good binding affinities values of -7.8, -8, -8.2, -8.2 and -7.5 respectively than ciprofloxacin. Molecular docking studies revealed that the designed compounds interacted with DNA gyrase subunit B mainly through hydrogen bond and hydrophobic interaction. In silico studies were performed for all the compounds using Swiss ADME, PreADMET, Molinspiration, and Protox II. Based on docking and insilico studies, five compounds with good docking score and passing Lipinski’s rule were selected for synthesis. Chemical structures of the synthesized compounds were ascertained on the basic of their spectral data (IR and Mass). Invitro antibacterial activity for the synthesized compounds was performed by Agar-well diffusion method. The analysis of antibacterial activity results indicated that the compound 3d with 2, Bromo-4,5-dimethoxy benzaldehyde derivative, compound 3j with syringaldehyde derivative and compound 3r with para dimethyl aminobenzaldehyde derivative showed good activity and Compound 3b with vanillin derivative and compound 3f with 2,4-dimethoxybenzaldehyde exhibited lesser activity than standard gentamicin antibiotic against E.coli. In this view, the above work its basic concluded that the novel hybrid benzimidazolyl chalcone with a promising target and it can show effective antimicrobial agent

Wireless Power Transmission using Resonance Induction Technique

ABSTRACT: The major objective of this project is to build up a device for wireless power transfer (WPT). Wireless power transfer can make an extraordinary change in the field of the electrical engineering which eliminates the use of conventional copper cables and current carrying wires. WPT is based on strong coupling between electromagnetic resonant objects to transfer energy wirelessly between them. The tuned magnetic fields generated by the primary coil can be arranged to interact vigorously with matched secondary windings in distant equipment but far more weakly with any surrounding objects or materials such as radio signals or biological tissues. But for very long distances, microwave transmission is used for the effective transfer of power. KEYWORDS: wireless power transfer (WPT) ,magnetic fields , microwave transmission and electromagnetic resonant

A study on the association of diabetes and semen quality in and around Chennai, Tamil Nadu, India

Background: Globally prevalence of diabetes is gradually increasing in individual at reproductive stage. Uncontrolled blood sugar affects biological systems including reproductive. Thus, this study was aimed to analyze the association of diabetes and male infertility in and around Chennai. Methods: Fifty-four male participants who visited the fertility clinic was grouped in two based on the sugar value. An anthropometric measurement, clinical, blood, seminal parameters and life style behaviors was analyzed. All study variables was analyzed to examine the association of diabetes and semen quality. Results: Study results shows that people with diabetes had abnormal semen parameters as compared to non- diabetic study participants. Pearson’s correlation between the semen parameters and blood sugar value of the study participants showed semen parameters: volume (r=-0.28, p<0.05), count (r=-0.22, p<0.05), and motility (r=-0.23, p<0.05), has a significantly week negative correlation with blood sugar level.  Scatter plots also showed semen parameters:  volume (r2=-0.079), count (r2=-0.048), and motility (r2=-0.053), had a significantly week negative linear correlation with blood sugar level. Conclusions: From the study it was concluded that the uncontrolled blood sugar levels affect the reproductive health of the study participants.

The hidden burden of influenza: A review of the extra-pulmonary complications of influenza infection

Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest that influenza infection is frequently associated with a number of clinical syndromes that involve organ systems outside the respiratory tract. A comprehensive MEDLINE literature review of articles pertaining to extra-pulmonary complications of influenza infection, using organ-specific search terms, yielded 218 articles including case reports, epidemiologic investigations, and autopsy studies that were reviewed to determine the clinical involvement of other organs. The most frequently described clinical entities were viral myocarditis and viral encephalitis. Recognition of these extra-pulmonary complications is critical to determining the true burden of influenza infection and initiating organ-specific supportive care

CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies

Ubiquitination of the epidermal growth factor receptor (EGFR) by cbl and its cognate adaptor cbl-interacting protein of 85 kDa (CIN85) is known to play an essential role in directing this receptor to the lysosome for degradation. The mechanisms by which this ubiquitin modification is regulated are not fully defined, nor is it clear where this process occurs. In this study we show that EGFR activation leads to a pronounced src-mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR ubiquitination. Of importance, phospho-CIN85 interacts with the Rab5-positive endosome, where it mediates the sequestration of the ubiquitinated receptor into multivesicular bodies (MVBs) for subsequent degradation. These findings provide novel insights into how src- kinase–based regulation of a cbl adaptor regulates the fate of the EGFR

Antibacterial efficacy of Acacia nilotica, Aegle marmelos herbal extracts against Enterococcus faecalis: an invitro study

Background: Our objective was to evaluate the antibacterial efficacy of Acacia nilotica, Aegle marmelos herbal extracts against Enterococcus faecalis- an invitro study. Methods: The extraction of Acacia nilotica bark powder and Aegle marmelos leaf powder was done with following three solvents (Ethanol, methanol and acetone) keeping vancomycin as a positive control. Then the study groups were assigned as follows: group I: Acacia nilotica, group II: Aegle marmelos, group III: Combination of Acacia nilotica and Aegle marmelos, group IV: vancomycin. Preparation of the E. feacalis inoculum with the help of Mueller Hinton Broth. Antimicrobial efficacy was evaluated by agar well diffusion assay to determine the zone of inhibition and Minimum inhibitory concentration was evaluated. Results: Statistical analysis was performed by using one-way analysis of variance and compared by the Mann-Whitney test using the Statistical Package for the Social Sciences (SPSS) software, version 20.0. No zone of inhibition was identified for Aegle marmelos. Highest inhibitory zone against E. faecalis was seen for vancomycin (mean of 28.6 mm) followed by Acacia nilotica. Conclusions: Among the test groups, vancomycin exhibited highest antimicrobial efficiency. Compared with the herbal extracts which was statistically significant. The use of herbal alternatives might prove to be advantageous considering the several undesirable characteristics of vancomycin

Scattered Security System for Mobile Networks through Assorted Contraption

Malware is malevolent programming which irritates the system PC operation, hacking the touchy data and gets to the private frameworks. It is only a project which is particularly intended to harm the PC it might be an infection or worm. Along these lines, keeping in mind the end goal to defeat this issue a two-layer system model is exhibited for reenacting infection spread through both Bluetooth and SMS. The two strategies are examined for controlling the versatile infection engendering. i.e., preimmunization and versatile appropriation strategies drawing on the philosophy of self-sufficiency situated processing (AOC). Yet, this strategy does not consider the mixture infections that disperse by means of both BT and SMS channels. In this way, to expand the productivity of controlling the engendering of cell telephone infections, we present a creative methodology called a Hybrid infection identification model. The cross breed malware can be disseminated by both end to-end informing administrations through individual social correspondences and short-extend remote correspondence administrations. In this system, another differential comparison based technique is proposed to analyze the blended practices of   Delocalized virus and swell based spread for the cross breed malware in summed up informal communities including of individual and spatial social relations. A test result demonstrates that the proposed framework is computationally viable to recognize the crossover malware. Studies on the engendering of malware in versatile systems have uncovered that the spread of malware can be very inhomogeneous. Stage differing qualities, contact list use by the malware, grouping in the system structure, and so on can likewise prompt contrasting spreading rates. In this paper, a general formal structure is proposed for utilizing such heterogeneity to infer ideal fixing approaches that achieve the base total cost because of the spread of malware and the extra charge of fixing. Utilizing Pontryagin's Maximum Principle for a stratified scourge model, it is logically demonstrated that in the mean-field deterministic administration, ideal patch spreads are straightforward single-edge arrangements. Through numerical recreations, the conduct of ideal fixing approaches is examined in test topologies and their points of interest are illustrated