4 research outputs found

    Pathological changes of bone tissue and kidneys when implanted bone cement in experiment

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    Objective: to study the dynamics of morphological changes in the kidney and bone tissue after implantation of bone cement into the femoral bone experimentally. Material and methods. 90 male rats Wistar were divided into 3 groups. In group 1 (control) was carried out only cortical perforation of the diaphysis. The animals in group 2 is similar to the defect created cortical diaphysis of intraosseous bone cement was injected at a dose of 0.1 ml. Animals of group 3 were intact. Results. Methylmethacrylate monomer causes toxic damage bone and vascular endothelial maximally expressed at day 1-7, which promotes thrombus formation slows bone regeneration processes thigh tissue prolong the inflammatory response, thus providing the basis for a general toxic effect of methyl methacrylate and thrombotic complications. Toxic kidney damage with the introduction of bone cement, the most pronounced in the 1 st - 7 th day day of the experiment, caused primarily by necrosis and apoptosis of endothelial cells of the glomeruli with the development of thrombosis of capillaries, epithelial cells of the proximal tubule, and the subsequent observation period - increase of the severity of interstitial inflammation.ЦСль исслСдования: ΠΈΠ·ΡƒΡ‡ΠΈΡ‚ΡŒ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡƒ морфологичСских ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π² костной Ρ‚ΠΊΠ°Π½ΠΈ ΠΈ ΠΏΠΎΡ‡ΠΊΠ°Ρ… послС ΠΈΠΌΠΏΠ»Π°Π½Ρ‚Π°Ρ†ΠΈΠΈ костного Ρ†Π΅ΠΌΠ΅Π½Ρ‚Π° Π² Π±Π΅Π΄Ρ€Π΅Π½Π½ΡƒΡŽ ΠΊΠΎΡΡ‚ΡŒ Π² экспСримСнтС. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π» ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹ исслСдования. 90 крыс-самцов Π»ΠΈΠ½ΠΈΠΈ Вистар Π±Ρ‹Π»ΠΈ Ρ€Π°Π·Π΄Π΅Π»Π΅Π½Ρ‹ Π½Π° 3 Π³Ρ€ΡƒΠΏΠΏΡ‹. Π’ 1-ΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅ (ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒ) Π²Ρ‹ΠΏΠΎΠ»Π½ΡΠ»Π°ΡΡŒ пСрфорация Ρ‚ΠΎΠ»ΡŒΠΊΠΎ ΠΊΠΎΡ€Ρ‚ΠΈΠΊΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ слоя Π΄ΠΈΠ°Ρ„ΠΈΠ·Π°. Π–ΠΈΠ²ΠΎΡ‚Π½Ρ‹ΠΌ 2-ΠΉ Π³Ρ€ΡƒΠΏΠΏΡ‹ Π² Π°Π½Π°Π»ΠΎΠ³ΠΈΡ‡Π½ΠΎ созданный Π΄Π΅Ρ„Π΅ΠΊΡ‚ ΠΊΠΎΡ€Ρ‚ΠΈΠΊΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ слоя Π΄ΠΈΠ°Ρ„ΠΈΠ·Π° внутрикостно вводился костный Ρ†Π΅ΠΌΠ΅Π½Ρ‚ Π² Π΄ΠΎΠ·Π΅ 0,1 ΠΌΠ». Π–ΠΈΠ²ΠΎΡ‚Π½Ρ‹Π΅ 3-ΠΉ Π³Ρ€ΡƒΠΏΠΏΡ‹ Π±Ρ‹Π»ΠΈ ΠΈΠ½Ρ‚Π°ΠΊΡ‚Π½Ρ‹ΠΌΠΈ. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ΠœΠΎΠ½ΠΎΠΌΠ΅Ρ€ ΠΌΠ΅Ρ‚ΠΈΠ»ΠΌΠ΅Ρ‚Π°ΠΊΡ€ΠΈΠ»Π°Ρ‚Π° Π²Ρ‹Π·Ρ‹Π²Π°Π΅Ρ‚ токсичСскоС ΠΏΠΎΠ²Ρ€Π΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ костной Ρ‚ΠΊΠ°Π½ΠΈ ΠΈ эндотСлия сосудов, максимально Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½Π½Ρ‹Π΅ Π½Π° 1-7 сутки, Ρ‡Ρ‚ΠΎ способствуСт Ρ‚Ρ€ΠΎΠΌΠ±ΠΎΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΡŽ, замСдляСт процСссы Ρ€Π΅Π³Π΅Π½Π΅Ρ€Π°Ρ†ΠΈΠΈ костной Ρ‚ΠΊΠ°Π½ΠΈ Π±Π΅Π΄Ρ€Π°, ΠΏΡ€ΠΎΠ»ΠΎΠ½Π³ΠΈΡ€ΡƒΠ΅Ρ‚ Π²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΡƒΡŽ Ρ€Π΅Π°ΠΊΡ†ΠΈΡŽ, Ρ‚Π΅ΠΌ самым создавая основу для ΠΎΠ±Ρ‰Π΅Π³ΠΎ токсичСского дСйствия ΠΌΠ΅Ρ‚ΠΈΠ»ΠΌΠ΅Ρ‚Π°ΠΊΡ€ΠΈΠ»Π°Ρ‚Π° ΠΈ тромботичСских ослоТнСний. ВоксичСскоС ΠΏΠΎΠ²Ρ€Π΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ ΠΏΠΎΡ‡Π΅ΠΊ ΠΏΡ€ΠΈ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ костного Ρ†Π΅ΠΌΠ΅Π½Ρ‚Π°, максимально Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½Π½ΠΎΠ΅ Π½Π° 1-Π΅ - 7 сутки сутки экспСримСнта, обусловлСно, ΠΏΡ€Π΅ΠΆΠ΄Π΅ всСго, Π½Π΅ΠΊΡ€ΠΎΠ·ΠΎΠΌ ΠΈ Π°ΠΏΠΎΠΏΡ‚ΠΎΠ·ΠΎΠΌ эндотСлиоцитов ΠΊΠ»ΡƒΠ±ΠΎΡ‡ΠΊΠΎΠ² с Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ΠΌ Ρ‚Ρ€ΠΎΠΌΠ±ΠΎΠ·Π° капилляров, эпитСлиоцитов ΠΏΡ€ΠΎΠΊΡΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹Ρ… ΠΊΠ°Π½Π°Π»ΡŒΡ†Π΅Π², Π° Π² ΠΏΠΎΡΠ»Π΅Π΄ΡƒΡŽΡ‰ΠΈΠΉ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ наблюдСния - нарастаниСм выраТСнности ΠΈΠ½Ρ‚Π΅Ρ€ΡΡ‚ΠΈΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ воспалСния

    Electrostatic Spray Modification in Gas Turbine Combustion

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    The feasibility of using electrostatic fields as a practical means of altering existing gas-turbine-injector spray characteristics has been investigated. Results indicate that with electrical potentials typical of spark plug voltages, a significant modification of spray characteristics in terms of average droplet size reduction and increased spray cone angles can be produced. This suggests a means of expanding the utility of present combustors either by broadening the operating range for optimum performance with the design or by permitting more attractive combustion of nondesign fuels. A simple retrofit during engine overhaul would allow present combustors to operate with or without electrostatic spray modification.The authors gratefully acknowledge the support of this work by its sponsor, the Naval Air Systems Command
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