The role of morphine in regulation of cancer cell growth

Morphine is considered the “gold standard” for relieving pain and is currently one of the most effective drugs available clinically for the management of severe pain associated with cancer. In addition to its use in the treatment of pain, morphine appears to be important in the regulation of neoplastic tissue. Although morphine acts directly on the central nervous system to relieve pain, its activities on peripheral tissues are responsible for many of the secondary complications. Therefore, understanding the impact, other than pain control, of morphine on cancer treatment is extremely important. The effect of morphine on tumor growth is still contradictory, as both growth-promoting and growth-inhibiting effects have been observed. Accumulating evidence suggests that morphine can affect proliferation and migration of tumor cells as well as angiogenesis. Various signaling pathways have been suggested to be involved in these extra-analgesic effects of morphine. Suppression of immune system by morphine is an additional complication. This review provides an update on the influence of morphine on the growth and migration potential of tumor cells

Method of giving bactericidal properties of cotton fibers with a new reactive derivative of polyhexamethylene guanidine

W artykule przedstawiono wyniki prac laboratoryjnych, mających na celu nadanie włóknom bawełnianym barwionym i niebarwionym właściwości bakteriobójczych. W tym celu wprowadzano do wyrobu włókienniczego nowo-opracowane preparaty bakteriobójcze pochodne reaktywne poliheksametylenoguanidyny (PHMG) na bazie 1,3,5-triazyny, zdolne do kowalencyjnego związania się z włóknem bawełnianym w temperaturze 25° w przypadku preparatu dichlorocyjanuro – PHMG (DC-PHMG) lub w temperaturze 60°C w przypadku preparatu monochlorocyjanuro – PHMG (MC-PHMG). Zmodyfikowana tkanina została poddana serii badań kolorystycznych i oceny skuteczności działania czynnika antybakteryjnego.The article presents the results of laboratory work aimed at giving cotton fibers stained and unpainted bactericidal properties. To this end, new 1,3-triazine 1,3-triazine-bactericidal reactive polyphenylene (PHMG) bactericidal preparations (PHMG), capable of covalently bonding to cotton fiber at 25° for the dichlorocyanurate-PHMG (DC-PHMG) or at 60° C for monochlorocyanuric-PHMG (MC-PHMG). The modified fabric has been subjected to a series of coloring tests and evaluate the effectiveness of the antimicrobial agent