The 2-10 keV XRB dipole and its cosmological implications

The hard X-ray (>2 keV) emission of the local and distant Universe as observed with the HEAO1-A2 experiment is reconsidered in the context of large scale cosmic structure. Using all-sky X-ray samples of AGN and galaxy clusters we remove the dominant local X-ray flux from within a redshift of ~ 0.02. We evaluate the dipolar and higher order harmonic structure in 4 X-ray colours. The estimated dipole anisotropy of the unresolved flux appears to be consistent with a combination of the Compton-Getting effect due to the Local Group motion (dipole amplitude Delta = 0.0042) and remaining large scale structure (0.0023 <~ Delta <~ 0.0085), in good agreement with the expectations of Cold Dark Matter models. The observed anisotropy does however also suggest a non-negligible Galactic contribution which is more complex than current, simple models of >2 keV Galactic X-ray emission. Comparison of the soft and hard colour maps with a harmonic analysis of the 1.5 keV ROSAT all-sky data qualitatively suggests that at least a third of the faint, unresolved ~ 18 deg scale structure in the HEAO1-A2 data may be Galactic in origin. However, the effect on measured flux dipoles is small (<~3%). We derive an expression for dipole anisotropy and acceleration and demonstrate how the dipole anisotropy of the distant X-ray frame can constrain the amplitude of bulk motions of the universe. From observed bulk motions over a local ~ 50 Mpc/h radius volume we determine 0.14 <~ Omega^0.6/b_x(0) <~ 0.59.Comment: 39 pages, Revised version accepted ApJ Main Journal, 3 new Figures + additional tex

Rubisco activation by wheat Rubisco activase isoform 2β is insensitive to inhibition by ADP

Rubisco activase (Rca) is a catalytic chaperone that remodels the active site, promotes the release of inhibitors and restores catalytic competence to Rubisco. Rca activity and its consequent effect on Rubisco activation and photosynthesis are modulated by changes to the chloroplast environment induced by fluctuations in light levels that reach the leaf, including redox status and adenosine diphosphate (ADP)/adenosine triphosphate (ATP) ratio. The Triticum aestivum (wheat) genome encodes for three Rca protein isoforms: 1β (42.7 kDa), 2β (42.2 kDa) and 2α (46.0 kDa). The regulatory properties of these isoforms were characterised by measuring rates of Rubisco activation and ATP hydrolysis by purified recombinant Rca proteins in the presence of physiological ADP/ATP ratios. ATP hydrolysis by all three isoforms was sensitive to inhibition by increasing amounts of ADP in the assay. In contrast, Rubisco activation activity of Rca 2β was insensitive to ADP inhibition, while Rca 1β and 2α were inhibited. Two double and one quadruple site-directed mutants were designed to elucidate if differences in the amino acid sequences between Rca 1β and 2β could explain the differences in ADP sensitivity. Changing two amino acids in Rca 2β to the corresponding residues in 1β (T358K & Q362E) resulted in significant inhibition of Rubisco activation in presence of ADP. The results show that the wheat Rca isoforms differ in their regulatory properties and that amino acid changes in the C domain influence ADP sensitivity. Advances in the understanding of Rubisco regulation will aid efforts to improve the efficiency of photosynthetic CO2 assimilation

Low power BL Lacertae objects and the blazar sequence: Clues on the particle acceleration process

The spectral properties of blazars seem to follow a phenomenological sequence according to the source luminosity. By inferring the source physical parameters through (necessarily) modeling the blazar spectra, we have previously proposed that the sequence arises because the particles responsible for most of the emission suffer increasing radiative losses as the luminosity increases. Here we extend those results by considering the widest possible range of blazar spectral properties. We find a new important ingredient for shaping the spectra of the lowest power objects, namely the role of a finite timescale for the injection of relativistic particles. Only high energy particles radiatively cool in such timescale leading to a break in the particle distribution: particles with this break energy are those emitting most of the power, and this gives raise to a link between blazar spectra and total energy density inside the source, which controls the cooling timescale. The emerging picture requires two phases for the particle acceleration: a first pre-heating phase in which particles reach a characteristic energy as the result of balancing heating and radiative cooling, and a more rapid acceleration phase which further accelerate these particles to form a power law distribution. While in agreement with standard shock theory, this scenario also agrees with the idea that the luminosity of blazars is produced through internal shocks, which naturally lead to shocks lasting for a finite time.Comment: 10 pages, 5 figures, accepted for publication in A&

The X-ray absorber of PKS2126-158

BeppoSAX observed the z=3.27 quasar PKS2126-158 on 1999 May 24-28 when its 2-10keV and 0.1-2.5keV fluxes were 1.1E-11 and 4.4E-12 cgs respectively, a factor of 2 higher than in all previous ROSAT and ASCA observations and 40% higher than in two more recent Chandra and XMM-Newton observations. The shortest detected rest frame variability timescale is of a few months, comparable to the causal timescale associated to an emission region of ~10 Schwarzschild radii around a few 1E10 solar masses black hole. The source is detected with a signal to noise ratio S/N>=3 up to ~50 keV, 215 keV rest frame. The BeppoSAX observations confirm the presence of low energy absorption along the line of sight, independent on the continuum model adopted, at high confidence level. Despite the limited spectral resolution of the BeppoSAX LECS and MECS it is possible to put constraints on different absorption and continuum models, but not to unambiguously determine the redshift of the absorber. If the absorber is not significantly ionized the BeppoSAX data do prefer an absorber at z<=2.7. Strong and complex metal line systems along the line of sight to PKS2126-158 have been found at z=0.6631 and at 2.64<z<2.82. They could well be associated to the X-ray absorption. Conversely, an ionized (``warm'') absorber at the quasar redshift provides a good fit only if the iron abundance is smaller than ~0.3 solar, while that of the other elements is fixed to the solar value.Comment: A&A in pres

Bayes and health care research.

Bayes’ rule shows how one might rationally change one’s beliefs in the light of evidence. It is the foundation of a statistical method called Bayesianism. In health care research, Bayesianism has its advocates but the dominant statistical method is frequentism. There are at least two important philosophical differences between these methods. First, Bayesianism takes a subjectivist view of probability (i.e. that probability scores are statements of subjective belief, not objective fact) whilst frequentism takes an objectivist view. Second, Bayesianism is explicitly inductive (i.e. it shows how we may induce views about the world based on partial data from it) whereas frequentism is at least compatible with non-inductive views of scientific method, particularly the critical realism of Popper. Popper and others detail significant problems with induction. Frequentism’s apparent ability to avoid these, plus its ability to give a seemingly more scientific and objective take on probability, lies behind its philosophical appeal to health care researchers. However, there are also significant problems with frequentism, particularly its inability to assign probability scores to single events. Popper thus proposed an alternative objectivist view of probability, called propensity theory, which he allies to a theory of corroboration; but this too has significant problems, in particular, it may not successfully avoid induction. If this is so then Bayesianism might be philosophically the strongest of the statistical approaches. The article sets out a number of its philosophical and methodological attractions. Finally, it outlines a way in which critical realism and Bayesianism might work together. </p

Lessons from the development process of the Afghanistan integrated package of essential health services

In 2017, in the middle of the armed conflict with the Taliban, the Ministry of Public Health decided that the Afghan health system needed a well-defined priority package of health services taking into account the increasing burden of non-communicable diseases and injuries and benefiting from the latest evidence published by DCP3. This leads to a 2-year process involving data analysis, modelling and national consultations, which produce this Integrated Package of Essential health Services (IPEHS). The IPEHS was finalised just before the takeover by the Taliban and could not be implemented. The Afghanistan experience has highlighted the need to address not only the content of a more comprehensive benefit package, but also its implementation and financing. The IPEHS could be used as a basis to help professionals and the new authorities to define their priorities

Discoverer - Making commercial satellite operations in very low earth orbit a reality

DISCOVERER is a €5.7M European Commission funded Horizon 2020 project developing technologies to enable commercially-viable sustained-operation of satellites in very low Earth orbits. Why operate closer to the Earth? For communications applications latency is significantly reduced and link budgets improved, and for remote sensing improved link budgets allow higher resolution or smaller instruments, all providing cost benefits. In addition, all applications benefit from increased launch mass to lower altitudes, whilst end-of-life removal is ensured due to the increased atmospheric drag. However, this drag must also be minimised and compensated for. One of the key technologies being developed by DISCOVERER are materials that encourage specular reflection of the residual atmosphere at these altitudes. Combined with appropriate geometric designs these can significantly reduce drag, provide usable lift for aerodynamic attitude and orbit control, and improve the collection efficiency of aerodynamic intakes for atmosphere breathing electric propulsion systems, all of which are being developed as part of DISCOVERER. The paper provides highlights from the developments to date, and the potential for a new class of aerodynamic commercial satellites operating at altitudes below the International Space Station

Concepts and Applications of Aerodynamic Attitude and Orbital Control for Spacecraft in Very Low Earth Orbit

Spacecraft operations below 450km, namely Very Low Earth Orbit (VLEO), can offer significant advantages over traditional low Earth orbits, for example enhanced ground resolution for Earth observation, improved communications latency and link budget, or improved signal-to-noise ratio. Recently, these lower orbits have begun to be exploited as a result of technology development, particularly component miniaturisation and cost-reduction, and concerns over the increasing debris population in commercially exploited orbits. However, the high cost of orbital launch and challenges associated with atmospheric drag, causing orbital decay and eventually re-entry are still a key barrier to their wider use for large commercial and civil spacecraft. Efforts to address the impact of aerodynamic drag are being sought through the development of novel drag-compensation propulsion systems and identification of materials which can reduce aerodynamic drag by specularly reflecting the incident gas. However, the presence of aerodynamic forces can also be utilised to augment or improve spacecraft operations at these very low altitudes by providing the capability to perform coarse pointing control and trim or internal momentum management for example. This paper presents concepts for the advantageous use of spacecraft aerodynamics developed as part of DISCOVERER, a Horizon 2020 funded project with the aim to revolutionise Earth observation satellite operations in VLEO. The combination of novel spacecraft geometries and use of aerodynamic control methods are explored, demonstrating the potential for a new generation of Earth observation satellites operating at lower altitudes