Particle Acceleration by Fast Modes in Solar Flares

We address the problem of particle acceleration in solar flares by fast modes which may be excited during the reconnection and undergo cascade and are subjected to damping. We extend the calculations beyond quasilinear approximation and compare the acceleration and scattering by transit time damping and gyroresonance interactions. We find that the acceleration is dominated by the so called transit time damping mechanism. We estimate the total energy transferred into particles, and show that our approach provides sufficiently accurate results We compare this rate with energy loss rate. Scattering by fast modes appears to be sufficient to prevent the protons from escaping the system during the acceleration. Confinement of electrons, on the other hand, requires the existence of plasma waves. Electrons can be accelerated to GeV energies through the process described here for solar flare conditions.Comment: 7 pages, 4 figures, accepted to Ap

Heating and Acceleration of Intracluster Medium Electrons by Turbulence

In this paper we investigate the feasibility of bremsstrahlung radiation from `nonthermal' electrons as a source of hard X-rays from the intracluster medium of clusters of galaxies. With an exact treatment of the Coulomb collisions in a Fokker-Planck analysis of the electron distribution we find that the severe difficulties with lifetimes of `nonthermal' particles found earlier by Petrosian (2001) using a cold target model remain problematic. We then address possible acceleration of background electrons into a nonthermal tail. We assume a simplified but generic acceleration rate and determine the expected evolution of an initially Maxwellian distribution of electrons. We find that strong nonthermal components arise only for rapid rate of acceleration which also heats up the entire plasma. These results confirm the conclusion that if the observed `nonthermal' excesses are due to some process accelerating the background thermal electrons this process must be short lived.Comment: 28 pages, 7 figures. Astrophysical Journal, in pres

Risk of new-onset Long Covid following reinfection with SARS-CoV-2: community-based cohort study

Background: Little is known about the risk of Long Covid following reinfection with SARS-CoV-2. We estimated the likelihood of new-onset, self-reported Long Covid after a second SARS-CoV-2 infection, and compared to a first infection. // Methods: We included UK COVID-19 Infection Survey participants who tested positive for SARS-CoV-2 between 1 November 2021 and 8 October 2022. The primary outcome was self-reported Long Covid 12 to 20 weeks after each infection. Separate analyses were performed for those <16 years and ≥16 years. We estimated adjusted odds ratios (aORs) for new-onset Long Covid using logistic regression, comparing second to first infections, controlling for socio-demographic characteristics and calendar date of infection, plus vaccination status in those ≥16 years. // Results: Overall, Long Covid was reported by those ≥16 years after 4.0% and 2.4% of first and second infections, respectively; the corresponding estimates among those <16 years were 1.0% and 0.6%. The aOR for Long Covid after second compared to first infections was 0.72 (95% confidence interval: 0.63–0.81) for those ≥16 years and 0.93 (0.57–1.53) for those <16 years. // Conclusions: The risk of new-onset Long Covid after a second SARS-CoV-2 infection is lower than that after a first infection for those ≥16 years, though there is no evidence of a difference in risk for those <16 years. However, there remains some risk of new-onset Long Covid after a second infection, with around 1 in 40 of those ≥16 years and 1 in 165 of those <16 years reporting Long Covid after a second infection

Risk of Long Covid in people infected with SARS-CoV-2 after two doses of a COVID-19 vaccine: community-based, matched cohort study

We investigated Long Covid incidence by vaccination status in a random sample of UK adults from April 2020 to November 2021. Persistent symptoms were reported by 9.5% of 3,090 breakthrough SARS-CoV-2 infections and 14.6% of unvaccinated controls (adjusted odds ratio 0.59, 95% CI: 0.50-0.69), emphasising the need for public health initiatives to increase population-level vaccine uptake

Employment outcomes of people with Long Covid symptoms: community-based cohort study

Background Evidence on the long-term employment consequences of SARS-CoV-2 infection is lacking. We used data from a large, community-based sample in the UK to estimate associations between Long Covid and employment outcomes. Methods This was an observational, longitudinal study using a pre–post design. We included survey participants from 3 February 2021 to 30 September 2022 when they were aged 16–64 years and not in education. Using conditional logit modelling, we explored the time-varying relationship between Long Covid status ≥12 weeks after a first test-confirmed SARS-CoV-2 infection (reference: pre-infection) and labour market inactivity (neither working nor looking for work) or workplace absence lasting ≥4 weeks. Results Of 206 299 participants (mean age 45 years, 54% female, 92% white), 15% were ever labour market inactive and 10% were ever long-term absent during follow-up. Compared with pre-infection, inactivity was higher in participants reporting Long Covid 30 to <40 weeks [adjusted odds ratio (aOR): 1.45; 95% CI: 1.17–1.81] or 40 to <52 weeks (aOR: 1.34; 95% CI: 1.05–1.72) post-infection. Combining with official statistics on Long Covid prevalence, and assuming a correct statistical model, our estimates translate to 27 000 (95% CI: 6000–47 000) working-age adults in the UK being inactive because of Long Covid in July 2022. Conclusions Long Covid is likely to have contributed to reduced participation in the UK labour market, though it is unlikely to be the sole driver. Further research is required to quantify the contribution of other factors, such as indirect health effects of the pandemic

Hospital treatment -is it affordable? A structured cost analysis of vaginal deliveries and planned caesarean sections

<p>Abstract</p> <p>Introduction</p> <p>The analysis of cost effectiveness in hospitals is as difficult as treating the patients properly. We are yet not able to answer the simple question of what costs are caused by a certain diagnosis and its treatment during an average hospital stay.</p> <p>Methods</p> <p>To answer some issues of the global problem of cost effectiveness during hospitalisation, we analysed the costs and the cost structure of a normal obstetrical hospital stay during an uncomplicated vaginal delivery and a planned caesarean section. Cost data was collected and summarized from the patients file, the hospital's computer system gathering all cost centres, known material expenses and expenses of non obstetrical medical services.</p> <p>Results</p> <p>For vaginal deliveries/planned caesareans we can calculate with a surplus of about 83 €/1432 €. About 45% of the summarized costs are calculated on a reliable database.</p> <p>Discussion</p> <p>The introduction of the DRG based clearing system in Germany has aggravated the discussion on cost effectiveness. Our meticulous work-up of expenses excluded personal precautionary costs and personnel costs of documentation because no tools are described to depict such costs. If we would add these costs to the known expenses of our study, we strongly suspect that hospital treatment of vaginal deliveries or planned caesarean sections is not cost effective.</p

An external validation of the QCOVID3 risk prediction algorithm for risk of hospitalisation and death from COVID-19: An observational, prospective cohort study of 1.66m vaccinated adults in Wales, UK

Introduction At the start of the COVID-19 pandemic there was an urgent need to identify individuals at highest risk of severe outcomes, such as hospitalisation and death following infection. The QCOVID risk prediction algorithms emerged as key tools in facilitating this which were further developed during the second wave of the COVID-19 pandemic to identify groups of people at highest risk of severe COVID-19 related outcomes following one or two doses of vaccine. Objectives To externally validate the QCOVID3 algorithm based on primary and secondary care records for Wales, UK. Methods We conducted an observational, prospective cohort based on electronic health care records for 1.66m vaccinated adults living in Wales on 8th December 2020, with follow-up until 15th June 2021. Follow-up started from day 14 post vaccination to allow the full effect of the vaccine. Results The scores produced by the QCOVID3 risk algorithm showed high levels of discrimination for both COVID-19 related deaths and hospital admissions and good calibration (Harrell C statistic: ≥ 0.828). Conclusion This validation of the updated QCOVID3 risk algorithms in the adult vaccinated Welsh population has shown that the algorithms are valid for use in the Welsh population, and applicable on a population independent of the original study, which has not been previously reported. This study provides further evidence that the QCOVID algorithms can help inform public health risk management on the ongoing surveillance and intervention to manage COVID-19 related risks

Total Galaxy Magnitudes and Effective Radii from Petrosian Magnitudes and Radii

Petrosian magnitudes were designed to help with the difficult task of determining a galaxy's total light. Although these magnitudes (taken here as the flux within 2R_P, with the inverted Petrosian index 1/eta(R_P)=0.2) can represent most of an object's flux, they do of course miss the light outside of the Petrosian aperture (2R_P). The size of this flux deficit varies monotonically with the shape of a galaxy's light-profile, i.e., its concentration. In the case of a de Vaucouleurs R^{1/4} profile, the deficit is 0.20 mag; for an R^{1/8} profile this figure rises to 0.50 mag. Here we provide a simple method for recovering total (Sersic) magnitudes from Petrosian magnitudes using only the galaxy concentration (R_90/R_50 or R_80/R_20) within the Petrosian aperture. The corrections hold to the extent that Sersic's model provides a good description of a galaxy's luminosity profile. We show how the concentration can also be used to convert Petrosian radii into effective half-light radii, enabling a robust measure of the mean effective surface brightness. Our technique is applied to the SDSS DR2 Petrosian parameters, yielding good agreement with the total magnitudes, effective radii, and mean effective surface brightnesses obtained from the NYU--VAGC Sersic R^{1/n} fits by Blanton et al. (2005). Although the corrective procedure described here is specifically applicable to the SDSS DR2 and DR3, it is generally applicable to all imaging data where any Petrosian index and concentration can be constructed.Comment: AJ, in press after minor additions to the text (7 pages of text, plus 6 of figures and tables

Nonthermal radiation mechanisms

In this paper we review the possible radiation mechanisms for the observed non-thermal emission in clusters of galaxies, with a primary focus on the radio and hard X-ray emission. We show that the difficulty with the non-thermal, non-relativistic Bremsstrahlung model for the hard X-ray emission, first pointed out by Petrosian (2001) using a cold target approximation, is somewhat alleviated when one treats the problem more exactly by including the fact that the background plasma particle energies are on average a factor of 10 below the energy of the non-thermal particles. This increases the lifetime of the non-thermal particles, and as a result decreases the extreme energy requirement, but at most by a factor of three. We then review the synchrotron and so-called inverse Compton emission by relativistic electrons, which when compared with observations can constrain the value of the magnetic field and energy of relativistic electrons. This model requires a low value of the magnetic field which is far from the equipartition value. We briefly review the possibilities of gamma-ray emission and prospects for GLAST observations. We also present a toy model of the non-thermal electron spectra that are produced by the acceleration mechanisms discussed in an accompanying paper.Comment: 17 pages, 6 figures, accepted for publication in Space Science Reviews, special issue "Clusters of galaxies: beyond the thermal view", Editor J.S. Kaastra, Chapter 10; work done by an international team at the International Space Science Institute (ISSI), Bern, organised by J.S. Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke