Long Lamai community ICT4D E‐commerce system modelling: an agent oriented role‐based approach

This paper presents the post‐mortem report upon completion of the Long Lamai e‐commerce development project. Some weaknesses with regards to the current software modelling approach are identified and an alternative role‐based approach is proposed. We argue that the existing software modelling technique is not suitable for modelling, making it difficult to establish a good contract between stakeholders causing delays in the project delivery. The role‐based approach is able to explicitly highlight the responsibilities among stakeholders, while also forming the contract agreement among them leading towards sustainable ICT4D

Crystal structure of antigen TpF1 from Treponema pallidum.

Several bacterial genomes code for pro- teins belonging to the Dps family, which includes dodecam- ers, made up of 12 identical subunits, each of them with a four-helix bundle folding similar to that of ferritins. The crystal structure of several members of the family have been determined: Dps from Escherichia coli (1DPS, 1F30, 1F33, 1JRE, 1JTS, 1L8H, 1L8I),1 Listeria Innocua Dps (1QGH, 2BJY, 2BK6, 2BKC),2,3 HP-NAP from Helicobac- ter pylori (1JI4),4 Dlp1 and Dlp2 from Bacillus anthracis (1JI5, 1JIG),5 archaeal Dps-homolog from Halobacterium salinarum (1MOJ, 1TJO),6 Dps protein from Bacillus brevis (1N1Q),7 Agrobacterium tumefaciens Dps (1O9R),8 Dps-like peroxide resistance protein from Streptococcus suis (1UMN),9 Dps from Mycobacterium smegmatis (1VEI, 1VEQ, 1UVH).10 Despite their structural similarity and the fact that most of these proteins are capable of incorporating iron in vitro, their biological function appear to differ among family members. The E. coli and the B. subtilis proteins protect DNA from oxidative damage (Dps, DNA protecting protein under starved conditions),11\u201313 whereas the L. innocua protein (Flp) is a true dodecameric ferritin func- tioning in iron storage.2 The FtpA protein from H. ducreyi is a structural protein of fine tangled pili.14 At variance from these Dps proteins, the H. pylori homolog HP-NAP appears to display different activities. It induces migration and activation of human neutrophils and monocytes,15 adhesion of neutrophils to endothelial cells,16 and it causes mast cell degranulation.17 HP-NAP binds to neutrophil glycosphingolipids and to mucin, a component of the stomach mucus layer.18,19 A major property of HP-NAP is that of being highly immunogenic in humans.20,21 This property is shared by a Dps-like protein, named TpF1, produced by Treponema pallidum,22\u201325 and therefore, we decided to undertake the determination of the crystal structure of this protein, which is presented in this report

Social and Mental Alienation in Italy between the Economic Miracle and the Years of Lead

This chapter discusses the multiple meanings of the notion of alienation, providing some essential coordinates for the understanding of such a slippery concept. This chapter proceeds by contextualizing what we call the “years of alienation” and explaining why we believe this is a particularly telling label for Italy’s sociopolitical and cultural situation between the so-called Economic Boom and the Years of Lead (1958–1980). In order to do so, we explore, on the one hand, the ideological debate on alienation understood in its sociopolitical connotations, which found in literature and cinema a privileged site of elaboration; and on the other hand, Franco Basaglia’s subversion of the field of psychiatric health care. In particular, we pay attention to the clinical and the political meanings that mental alienation took on in this context, and the influence this revolution in psychiatry had on literature, cinema, and popular music