Leading-edge receptivity to a vortical freestream disturbance: A numerical analysis

The receptivity to freestream vorticity of the boundary layer over a flat plate with an elliptic leading edge is investigated numerically. The flow is simulated by solving the incompressible Navier-Stokes system in general curvilinear coordinates with the vorticity and stream function as dependent variables. A finite-difference scheme which is second-order accurate in both space and time is used. As a first step, the steady basic-state solution is computed. Then a small amplitude vortical disturbance is introduced at the upstream boundary and the governing equations are solved time-accurately to evaluate the spatial and temporal growth of the perturbations leading to instability waves (Tollmien-Schlichting waves) inside the boundary layer. Preliminary results for a symmetric, 2-D disturbance reveal the presence of Tollmien-Schlichting waves aft of the flat-plate/ellipse juncture

Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection.

Consistent with Dr. Paul Terasaki's "humoral theory of rejection" numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies to non-HLA antigens in AMR and allograft injury. Despite the remarkable efforts by leaders in the field who pioneered single antigen bead technology for detection of donor specific antibodies, a considerable amount of work is still needed to better define the antibody attributes that are associated with AMR pathology. This review highlights what is currently known about the clinical context of pre and posttransplant antibodies, antibody characteristics that influence AMR, and the paths after donor specific antibody production (no rejection, subclinical rejection, and clinical dysfunction with AMR)

Measuring Damages to Marine Natural Resources from Pollution Incidents under CERCLA: Applications of an Integrated Ocean Systems/Economic Model

Several pieces of federal environmental regulation establish strict liability for damages from spills of oil and hazardous substances. This paper discusses the Natural Resource Damage Assessment Model for Coastal and Marine Environments (NRDAMICME), which is to be used for assessing damages from spills of oil or hazardous substances in coastal and marine environments under CERCLA and the Clean Water Act, as amended. The approach employs an integrated ocean systems/economic model to simulate the physical fates and biological effects of a spill and to measure the resulting economic damages. To illustrate application of the model, selected results are presented for hypothetical spills of a number of substances in a variety of environments. The results show that the damage function depends on the physical and chemical properties of the substance spilled, the season, and the environment in which the spill occurs.Environmental Economics and Policy, Research Methods/ Statistical Methods, Resource /Energy Economics and Policy, Risk and Uncertainty,

Use of the sitting position for pineal tumour surgery in a five-year-old child

The sitting position provides almost ideal access to several areas within the cranium. The high risk of air embolism has led to decreased use of the sitting position. However, improved identification of patients at risk of paradoxical embolism may allow a more calculated, safer use thereof. Despite an improved understanding of the risks, many neurosurgical centres seldom use this position, and the occasional use of a complex patient position can then create additional challenges. This case report of a child requiring pineal surgery in the sitting position includes a review of the use of this position in children, and highlights the current emphasis on assessing the risk of paradoxical embolism before proceeding to the use of such a position.South Afr J Anaesth Analg, 2011;17(6):388-39

Probability distributions of smeared quantum stress tensors

We obtain in closed form the probability distribution for individual measurements of the stress-energy tensor of two-dimensional conformal field theory in the vacuum state, smeared in time against a Gaussian test function. The result is a shifted Gamma distribution with the shift given by the previously known optimal quantum inequality bound. For small values of the central charge it is overwhelmingly likely that individual measurements of the sampled energy density in the vacuum give negative results. For the case of a single massless scalar field, the probability of finding a negative value is 84%. We also report on computations for four-dimensional massless scalar fields showing that the probability distribution of the smeared square field is also a shifted Gamma distribution, but that the distribution of the energy density is not.Comment: 9 pages, 1 figure. Minor edits implemente

An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA.

Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells. While F(ab')2 portions of DSA cause cellular activation and proliferation, Fc regions activate the classical complement cascade, resulting in complement deposition and leukocyte recruitment, both hallmark features of AMR. We characterized the ability of an anti-C1s monoclonal antibody, TNT003, to inhibit HLA antibody (HLA-Ab)-induced complement activation. Complement deposition induced by HLA-Ab was evaluated using novel cell- and bead-based assays. Human aortic endothelial cells (HAEC) were cultured with HLA-Ab and human complement; production of activated complement proteins was measured by flow cytometry. Additionally, C3d deposition was measured on single antigen beads (SAB) mixed with HLA-Ab and human complement. TNT003 inhibited HLA-Ab mediated complement deposition on HAEC in a concentration-dependent manner; C3a, C4a and C5a anaphylatoxin production was also diminished by TNT003. Finally, TNT003 blocked C3d deposition induced by Class I (HLAI-Ab)- and Class II (HLAII-Ab)-specific antibodies on SAB. These data suggest TNT003 may be useful for modulating the effects of DSA, as TNT003 inhibits complement deposition and split product formation generated by HLA-I/II-Ab in vitro

On the Relation between Rigging Inner Product and Master Constraint Direct Integral Decomposition

Canonical quantisation of constrained systems with first class constraints via Dirac's operator constraint method proceeds by the thory of Rigged Hilbert spaces, sometimes also called Refined Algebraic Quantisation (RAQ). This method can work when the constraints form a Lie algebra. When the constraints only close with nontrivial structure functions, the Rigging map can no longer be defined. To overcome this obstacle, the Master Constraint Method has been proposed which replaces the individual constraints by a weighted sum of absolute squares of the constraints. Now the direct integral decomposition methods (DID), which are closely related to Rigged Hilbert spaces, become available and have been successfully tested in various situations. It is relatively straightforward to relate the Rigging Inner Product to the path integral that one obtains via reduced phase space methods. However, for the Master Constraint this is not at all obvious. In this paper we find sufficient conditions under which such a relation can be established. Key to our analysis is the possibility to pass to equivalent, Abelian constraints, at least locally in phase space. Then the Master Constraint DID for those Abelian constraints can be directly related to the Rigging Map and therefore has a path integral formulation.Comment: 25 page

Magnetic transport in a straight parabolic channel

We study a charged two-dimensional particle confined to a straight parabolic-potential channel and exposed to a homogeneous magnetic field under influence of a potential perturbation $W$. If $W$ is bounded and periodic along the channel, a perturbative argument yields the absolute continuity of the bottom of the spectrum. We show it can have any finite number of open gaps provided the confining potential is sufficiently strong. However, if $W$ depends on the periodic variable only, we prove by Thomas argument that the whole spectrum is absolutely continuous, irrespectively of the size of the perturbation. On the other hand, if $W$ is small and satisfies a weak localization condition in the the longitudinal direction, we prove by Mourre method that a part of the absolutely continuous spectrum persists