Evaluation of response reduction factor and ductility factorfor RC braced frame

Response reduction factor is the factor by which the actual base shear force should be reduced, to obtain the design lateral force during design basic earthquake (DBE) shaking. The response reduction factor (R) is basically depends on Over strength (Rs), Ductility (Rµ), Redundancy (RR). So there is a need to come up with realistic R factors for different structural systems used in various countries. In the present study efforts are made to evaluate the response reduction factor and ductility of RC braced frame using nonlinear static pushover analysis. The types of the frame considered in this study are RC frame with X bracing at centre bay, RC frame with X bracing at alternate bays, shear wall at canter and alternate bays. The result of this study shows that R factor and lateral strength of RC frames are considerably affected by the types and arrangement of the bracing system

Evaluation of response reduction factor and ductility factorfor RC braced frame

Response reduction factor is the factor by which the actual base shear force should be reduced, to obtain the design lateral force during design basic earthquake (DBE) shaking. The response reduction factor (R) is basically depends on Over strength (Rs), Ductility (Rµ), Redundancy (RR). So there is a need to come up with realistic R factors for different structural systems used in various countries. In the present study efforts are made to evaluate the response reduction factor and ductility of RC braced frame using nonlinear static pushover analysis. The types of the frame considered in this study are RC frame with X bracing at centre bay, RC frame with X bracing at alternate bays, shear wall at canter and alternate bays. The result of this study shows that R factor and lateral strength of RC frames are considerably affected by the types and arrangement of the bracing system

IMMEDIATE RELEASE SOLID DISPERSION TABLET OF AZILSARTAN: FORMULATION STRATEGY TO ENHANCE ORAL BIOAVAILABILITY

Objective: Objective of the present study was to develop an immediate release solid dispersion tablet to enhance oral bioavailability of Azilsartan. Methods: Solid dispersion of azilsartan was developed using Soluplus® as a novel solubility enhancer by the solvent evaporation technique. 32factorial design was used in a fully randomized order to study effect of amount of azilsartan and Soluplus on solubility (µg/ml) and % drug dissolved in 30 min. Prepared solid dispersion was evaluated for different micromeritic properties, saturation solubility, and wettability. Then solid dispersion of all the batches compressed into an immediate-release tablet using sodium starch glycolate as a super disintegrant. Developed tablet formulations were evaluated for various post-compression parameters and satisfactory formulation among these were further studied for Fourier-transform infrared spectroscopy (FTIR), Differential Scanning Colorimeter (DSC), X-Ray Diffraction (XRD), in vivo absorption and stability study. Results: Results of micromeritic properties of solid dispersion showed that good flowability, compressibility, wettability, and saturation solubility. Post compression parameters of immediate-release tablets were found to be in acceptable limits. Batch ASD2 containing 40 mg Diacerein and 80 mg of Soluplus showed maximum drug release i.e. 99.82 % within 30 min. Compatibility study using FTIR, DSC, and XRD showed that drug is compatible with Soluplus. In vivo absorption study showed that, 2.67 fold increase in Area Under Curve (AUC) as compared to plain Azilsartan. Relative bioavailability was found to be 267.11 %. Results of stability study indicate that developed formulations were stable at accelerated temperature and humidity conditions. Conclusion: Study concluded that solid dispersion using Soluplus as a solubility enhancer is a suitable formulation strategy to enhance solubility, dissolution, and bioavailability of poorly water-soluble drug-like Azilsartan

DEVELOPMENT OF SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF DIACEREIN FOR ENHANCED DISSOLUTION RATE

Objective: The objective of the present study was to develop solid self-microemulsifying drug delivery system (S-SMEDDS) of diacerein (DCN) for enhancement of dissolution rate. Methods: Three batches of liquid SMEDDS were prepared using oleic acid, Tween 80, and polyethylene glycol 200 as oil, surfactant, and cosurfactant, respectively. Microemulsion region was recognized by constructing a pseudoternary phase diagram containing a different proportion of oil, surfactant, and cosurfactant. Prepared liquid SMEDDS was evaluated for thermodynamic stability study, dispersibility tests, globule size, zeta potential, and viscosity. Liquid SMEDDS was then converted to S-SMEDDS by adsorption technique using Neusilin US2 as a solid carrier. Prepared S-SMEDDS was evaluated for different micromeritic properties, drug content, reconstitution properties, in vitro dissolution study, Fourier transform infrared, and scanning electron microscopy. Results: The results showed that all batches of liquid SMEDDS were found to be thermodynamically stable. Reconstitution properties of S-SMEDDS showed spontaneous microemulsification with globule size 0.271 μm and −16.18 mV zeta potential. From the results of in vitro dissolution study, it was found that the release of DCN was significantly increased as compared with plain DCN. Conclusion: The study concluded that dissolution rate of poorly water-soluble drug like DCN can be increased by developing S-SMEDDS formulation

Conformal GaP layers on Si wire arrays for solar energy applications

We report conformal, epitaxial growth of GaP layers on arrays of Si microwires. Silicon wires grown using chlorosilane chemical vapor deposition were coated with GaP grown by metal-organic chemical vapor deposition. The crystalline quality of conformal, epitaxial GaP/Si wire arrays was assessed by transmission electron microscopy and x-ray diffraction. Hall measurements and photoluminescence show p- and n-type doping with high electron mobility and bright optical emission. GaP pn homojunction diodes on planar reference samples show photovoltaic response with an open circuit voltage of 660 mV

Discovery of Ranking Fraud for Mobile Apps

Ranking fraud within the mobile App market refers to deceitful or deceptive activities that have a purpose of bumping up the Apps within the quality list. Indeed, it becomes a lot of and a lot of frequent for App developers to use shady means that, like inflating their Apps’ sales or posting phony App ratings, to commit ranking fraud. Whereas the importance of preventing ranking fraud has been well known, there's restricted understanding and analysis during this space. to the current finish, during this paper, we offer a holistic read of ranking fraud and propose a ranking fraud detection system for mobile Apps. Specifically, we have a tendency to initial propose to accurately find the ranking fraud by mining the active periods, specifically leading sessions, of mobile Apps. Such leading sessions are often leveraged for sleuthing the native anomaly rather than international anomaly of App rankings. what is more, we have a tendency to investigate 3 kinds of evidences, i.e., ranking primarily based evidences, rating based evidences and review based evidences, by modeling Apps’ ranking, rating and review behaviors through applied math hypotheses tests

On the Sparsest Representation of Electrocardiograms

In recent years, telecardiology has been growing in significance, due to the shortage of local caregivers in various parts of the world. As the cardiac data volume grows, compact representation becomes imperative in view of bandwidth, storage, power and other constraints. In this backdrop, we present empirical studies on electrocardiogram (ECG) signal representation using a wide variety of wavelet bases. Specifically, we arrange the transform coefficients in decreasing order of magnitude, and count the number of coefficients accounting for 99% of the signal energy (a sparser representation requires less number). We observe that 'Symlet' and 'Daubechies' families generally offer more compact representation compared to Meyer wavelet as well as biorthogonal and reverse biorthogonal families. In particular, the sparsest representation is provided by the 'sym4' (closely followed by the 'db4') wavelet basis for a broad class of ECG signals. Interestingly, this behavior is observed quite consistently across all fifteen (twelve standard and three Frank) leads. Our study assumes significance in the context of basis selection for various ECG signal processing applications, including compression, denoising and compressive sensin

On the Sparsest Representation of Electrocardiograms

In recent years, telecardiology has been growing in significance, due to the shortage of local caregivers in various parts of the world. As the cardiac data volume grows, compact representation becomes imperative in view of bandwidth, storage, power and other constraints. In this backdrop, we present empirical studies on electrocardiogram (ECG) signal representation using a wide variety of wavelet bases. Specifically, we arrange the transform coefficients in decreasing order of magnitude, and count the number of coefficients accounting for 99% of the signal energy (a sparser representation requires less number). We observe that 'Symlet' and 'Daubechies' families generally offer more compact representation compared to Meyer wavelet as well as biorthogonal and reverse biorthogonal families. In particular, the sparsest representation is provided by the 'sym4' (closely followed by the 'db4') wavelet basis for a broad class of ECG signals. Interestingly, this behavior is observed quite consistently across all fifteen (twelve standard and three Frank) leads. Our study assumes significance in the context of basis selection for various ECG signal processing applications, including compression, denoising and compressive sensin