4,922 research outputs found
HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer
Homeobox (HOX) genes are conserved transcription factors which determine the anterior-posterior body axis patterning. HOXD8 is a member of HOX genes deregulated in several tumors such as lung carcinoma, neuroblastoma, glioma and colorectal cancer (CRC) in a context-dependent manner. In CRC, HOXD8 is downregulated in cancer tissues and metastatic foci as compared to normal tissues. Whether HOXD8 acts as a tumor suppressor of malignant progression and metastasis is still unclear. Also, the underlying mechanism of its function including the downstream targets is totally unknown. Here, we clarified the lower expression of HOXD8 in clinical colorectal cancer vs. normal colon tissues. Also, we showed that stable expression of HOXD8 in colorectal cancer cells significantly reduced the cell proliferation, anchorage-independent growth and invasion. Further, using The Cancer Genome Atlas (TCGA), we identified the genes associated with HOXD8 in order to demonstrate its function as a suppressor or a promoter of colorectal carcinoma. Among inversely related genes, apoptotic inhibitors like STK38 kinase and MYC were shown to be negatively associated with HOXD8. We demonstrated the ability of HOXD8 to upregulate executioner caspases 6 & 7 and cleaved PARP, thus inducing the apoptotic events in colorectal cancer cells
Elastocaloric response of PbTiO3 predicted from a first-principles effective Hamiltonian
A first-principles based effective Hamiltonian is used within a molecular
dynamics simulation to study the elastocaloric effect in PbTiO3. It is found
that the transition temperature is a linear function of uniaxial tensile
stress. Negative temperature change is calculated, when the uniaxial tensile
stress is switched off, as a function of initial temperature
Delta-T(T_initial). It is predicted that the formation of domain structures
under uniaxial tensile stress degrades the effectiveness of the elastocaloric
effect.Comment: 6 pages, 7 figures, published in JPS
Exciton Mott transition in Si Revealed by Terahertz Spectroscopy
Exciton Mott transition in Si is investigated by using terahertz time-domain
spectroscopy. The excitonic correlation as manifested by the 1s-2p resonance is
observed above the Mott density. The scattering rate of charge carriers is
prominently enhanced at the proximity of Mott density, which is attributed to
the non-vanishing exciton correlation in the metallic electron-hole plasma.
Concomitantly, the signature of plasmon-exciton coupling is observed in the
loss function spectra.Comment: 5 pages, 3 figure
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