The fibrinolytic response in injured animal tissues normally low in fibrinolytic activity

Rabbit skin, normally of low fibrinolytic activity, and guinea-pig skin, of medium activity, after crush injury or after the intradermal or subcutaneous injection of aluminum hydroxide, show a remarkable increase in fibrinolytic activity. The activity is caused by a plasminogen activator and is related to blood vessels. Occasionally, intense fibrinolytic activity was also observed in some specimens collected from various other organs normally low in activity. Thus two specimens of rabbit aorta, one specimen of rabbit trachea and one specimen of rabbit stomach showed increased activity related to pathological processes. One specimen of guinea-pig rectum showed intense fibrinolytic activity along the serosa

Localization of fibrinolytic activity and inhibition of plasmin in the spinal cord of rat, guinea pig, and rabbit

Fibrinolytic activity (caused by a plasminogen activator) in the spinal cord was highest in the rat, lowest in the rabbit, and intermediate in the guinea pig. In all species the activity was highest in relation to the pia mater. The central spinal canal was active in the rat and the rabbit, but mostly inactive in the guinea pig. Foci of activity were more numerous in the gray matter than in the white matter corresponding to the greater vascularity of the former. In all species ability to inhibit plasmin was related mainly to the gray matter, with an additional area related to the dura mater. The high fibrinolytic activity of the spinal leptomeninges may play a role in the pathogenesis of hemorrhagic processes related to the spinal cord. Chemicals/CAS: antiplasmin, 9049-68-7; Plasmin, EC 3.4.21.7; Plasminogen Activators, EC 3.4.21.