The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours

It is thought that the time interval between the antecedent pregnancy and diagnosis of gestational trophoblastic tumours (GTTs) may influence the outcome of these patients. In this study, we investigate the significance of this time interval. Multivariate analysis was used to investigate if the time interval was of prognostic significance from our cohort of 241 high-risk patients with GTT. Subsequent cutpoint analysis was used to determine an optimal cutpoint for the interval covariate. The outcome of these patients was plotted according to the Kaplan–Meier method. The time interval was of prognostic significance on multivariate analysis. A period of greater than 2.8 years after pregnancy was found to be of most significance. The 5-year overall survival was 62.0% (95% CI: 47–76%) for greater than 2.8 years vs 94% (95% CI: 91–97%) for less than 2.8 years (P<0.001). Multivariate analysis showed the presence of liver metastasis and the number of metastasis was also of prognostic importance. The interval between antecedent pregnancy and diagnosis in high-risk GTT is of prognostic significance. This gives some insight into the pathogenesis of the disease

Acoustic Cavitation Assisted Preparation of Poly(Acrylic Acid)-Halloysite nanoclay Hydrogel for Removal of Auramine O Dye from Effluent

Background: Dye molecules are non-biodegradable which leads to pollution of water. There it’s important to treat these dye molecules prior to their discharge into water. There are various methods to treat the polluted water, but which has certain drawbacks with respect to their efficacy. The aim of this paper to introduce ultrasonically synthesized polymer hydrogel for removal of dye molecules from effluent. Methods: Polyacrylic acid based synthesis of hydrogel was carried out with the aid of acoustic cavitation. Encapsulation and uniform dispersion of cross linker (Halloysite nanoclay) has been efficiently carried due to ultrasonic irradiation produced by acoustic cavitation. Also Auramine O dye was considered for dye adsorption study. Results: The dye absorptivity of the synthesized hydrogel was analysed for removal of Auramine O dye. The adsorption study was carried out under various pH values for 5.5 hours. It was perceived that highest % removal of dye occurred at pH 11 with contact time of 5 hours. Conclusion: Prepared hydrogel was examined for its swelling capacity using deionized water. From swelling behavior data it has been observed that synthesized hydrogel has good swelling capacity and follows non-Fickian diffusion. From pH study it was observed that percentage removal of dye was increasing linearly with respect to pH up to 12.The optimum values for pH and contact time for highest dye removal (78.93%) are thus found out to be 11 and 5 hours respectively. The adsorption isotherm model study showed that Langmuir adsorption isotherm model well fitted with the experimental data. </jats:sec