4,214 research outputs found
Networked by design: can policy constraints support the development of capabilities for collaborative innovation?
While there has been some recent interest in the behavioural effects of policies in support of innovation networks, this research field is still relatively new. In particular, an important but under-researched question for policy design is “what kind of networks” should be supported, if the objective of the policy is not just to fund successful innovation projects, but also to stimulate behavioural changes in the participants, such as increasing their ability to engage in collaborative innovation. By studying the case of the innovation policy programmes implemented by the regional government of Tuscany, in Italy, between 2002 and 2008, we assess whether the imposition of constraints on the design of innovation networks has enhanced the participants’ collaborative innovation capabilities, and we draw some general implications for policy
THE INHIBITORY EFFECT OF PROPOLIS AND CAFFEIC ACID PHENETHYLESTER ON CYCLOOXYGENASE ACTIVITY IN J774 MACROPHAGES.
The effect of an ethanolic extract of propolis, with and without CAPE, and some of its components on cyclooxygenase (COX-1 and COX-2) activity in J774 macrophages has been investigated. COX-1 and COX-2 activity, measaured as prostaglandin E-2 (PGE(2)) production, were concentration-dependently inhibited by propolis (C x 10(-3)-3 x 10(2) mugml(-1)) with an IC50 of 2.7 mugml(-1) and 4.8 x 10(-2) mugml(-1), respectively. Among the compounds tested pinocembrin and caffeic, ferulic, cinnamic and chlorogenic acids did not affect the activity of COX isoforms. Conversely, CAPE (2.8 x 10(-4)-28 mugml(-1); 10(-9)-10(-4) M) and galangin (2.7 x 10(-4)-27 mugml(-1); 10(-9)-10(-4) M) were effective, the last being about ten-twenty times less potent. In fact the IC50 of CAPE for COX-1 and COX-2 were 4.4 x 10(-1) mugml(-1) (1.5 x 10(-6) M) and 2 x 10(-3) mugml(-1) (6.3 x 10(-9) M), respectively. The IC50 of galangin were 3.7 mugml(-1) (15 x 10(-6) M) and 3 x 10(-2) mugml(-1) (120 x 10(-1) M), for COX-1 and COX-2 respectively. To better investigate the role of CAPE, we tested the action of the ethanolic extract of propolis deprived of CAPE, which resulted about ten times less potent than the extract with CAPE in the inhibition of both COX-1 and COX-2, with an IC50 of 30 mugml(-1) and 5.3 x 10(-1) mugml(-1), respectively. Moreover the comparison of the inhibition curves showed a significant difference (p < 0.001). These results suggest that both CAPE and galangin contribute to the overall activity of propolis, CAPE being more effective
Networked by design: can policy requirements influence organisations' networking behaviour?
An important, but under-researched, question in relation to policies funding networks of innovators is: what kind of innovation networks should be supported, if the policy objective is not just to sponsor successful innovation projects, but also to encourage the participants to form networks with desirable characteristics? Focusing on a set of policy programmes implemented by the regional government of Tuscany, in Italy, between 2002 and 2008, aimed at funding networks of collaborating organisations, we investigate whether the imposition of requirements on the composition of the networks that would be eligible for funding – in particular, the demand that networks should comply with minimum size and heterogeneity thresholds – influenced the participants' networking behaviour in the context of successive policy interventions. Our results show that these requirements immediately affected the size and composition of the project networks that applied for funding, although not always in the intended direction. However, these effects did not extend to the successive periods, when those requirements were no longer in force. This suggests that the imposition of policy requirements, per se, is unlikely to induce persistent changes in organizations' networking behaviour. Other approaches such as implementing outreach actions in order to encourage new organisations to participate in existing innovation networks and to form new ones, and additional measures designed to foster learning opportunities for the participants, might be more effective tools to influence the networking behaviour of participating organisations
A tale of persistent network additionality, with evidence from a regional policy
Adopting a counterfactual approach to the evaluation of a regional R&D; collaboration policy, carried out in Tuscany (Italy), we investigate different types of persistent network additionality, namely persistence effect, breadth effect, composition effect, and depth effect
The emergence of intermediary organizations: a network-based approach to the design of innovation policies
Book synopsis: Though its roots in the natural sciences go back to the early 20th century, complexity theory as a scientific framework has developed most rapidly since the 1970s. Increasingly, complexity theory has been integrated into the social sciences, and this groundbreaking Handbook on Complexity and Public Policy has brought together top thinkers in complexity and policy from around the world.
With contributions from Europe, North America, Brazil and China this comprehensive Handbook splits the topic into three cohesive parts: Theory and Tools, Methods and Modeling, and Application
Promoting successful innovation networks: a methodological contribution to regional policy evaluation and design. The case of Tuscany's innovation policies 2000-2006
Innovation intermediaries and performance-based incentives: a case study of regional innovation poles
A growing number of innovation policies rely on publicly funded innovation intermediaries to provide knowledge-intensive services to firms, particularly small and medium-sized ones. The performance of innovation intermediaries is often assessed using indicators that need to be closely aligned with policy objectives to be effective. However, this alignment is difficult to achieve and is often overlooked in practice. We analyse the relationship between performance indicators and the behaviour of intermediaries by examining a case study of innovation intermediaries funded with public resources in Tuscany (Italy). The intermediaries implemented actions that allowed them to achieve their performance targets rapidly. However, due to a misalignment between indicators and policy objectives, these actions were not entirely consistent with the latter. After reviewing the literature on this key issue, we build on our findings to suggest how to design performance indicators that can induce intermediaries to more effectively support the achievement of policy objectives
An eco-knowledge tool to support eco-design implementation inside design departments
In last years, an increasing attention on environmental matters is registered. Companies face environmental matters to increase the environmental performances of their products, forced by numerous legislations, normative and protocols and induced to the growing attention of consumers toward environmentally friendly products. However, observing the industrial context, it emerges there are several barriers for implementation of eco-design strategies inside design departments. The paper presents a tool which aims at both providing a basic guide on environmental sustainability issues and favouring the knowledge sharing among the different actors of the product design process. The core of the tool is a repository in which company materials, organized and collected in different forms, are collected. The repository contains several parts: training, guidelines, knowledge and milestone, accordingly to the type, structure and form of materials stored. The eco-design tool functions, structure, and workflow are presented and then preliminary test cases are described
THE ROLE OF THE PHENETHYLE ESTER OF CAFFEIC ACID ( CAPE) IN THE INHIBITION OF RAT LUNG CYCLOOXYGENASE ACTIVITY BY PROPOLIS.
n this study we investigated the effect of an ethanolic extract of propolis, with and without CAPE, and some of its components on cyclooxygenase (COX) activity. Propolis (0.00003-0.03%) significantly and concentration-dependently inhibited COX activity from lung homogenate of saline- or LPS-treated rats. Same results were obtained with CAPE (0.1-100 ÎĽM). COX activity from lung homogenate of saline- or LPS-treated rats was also inhibited by galangin (0.1-100 ÎĽM), although the inhibition induced by the lowest concentration was not significant. Caffeic, ferulic, cinnamic and chlorogenic acids and pinocembrin, (0.1-100 ÎĽM) did not affect COX activity. The inhibition curves showed that CAPE and propolis were equipotent inhibitors, whereas galangin was significantly (P<0.001) less potent than propolis and CAPE. In order to better investigate the role of CAPE, we tested the action of an ethanolic extract of propolis (0.00003-0.03%) without CAPE. This extract significantly and concentration-dependently inhibited COX activity from lung homogenate of saline- or LPS-treated rats, however, it resulted to be approximately 10 times less potent than the extract containing CAPE. The analysis of the inhibition curves of the extract with and without CAPE showed a significant (P<0.001) difference. These results suggest that both CAPE and galangin contribute to the overall activity of propolis, CAPE being more effective
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