Do successful tuberculosis vaccines need to be immunoregulatory rather than merely Th1-boosting?

Tuberculosis vaccine candidates are entering clinical studies in areas where BCG fails. This is a high-risk strategy. We suggest that geographical variation in the efficacy of BCG is related to the presence in developing countries of a cross-reactive background Th2-like response, probably attributable to exposure of mother and infant to helminths and environmental mycobacteria. Such Th2-like activity can stop Mycobacterium tuberculosis from being pushed into a latent state by the Th1 response, impair bactericidal functions and cause toxicity of TNF-alpha and pulmonary fibrosis. A successful vaccine, rather than driving a Th1 response, might need to suppress this pre-existing subversive Th2-like component. (c) 2005 Elsevier Ltd. All rights reserved

The 3-Dimensional Distribution of Dust in NGC 891

We produce three-dimensional Monte-Carlo radiative transfer models of the edge-on spiral galaxy NGC 891, a fast-rotating galaxy thought to be an analogue to the Milky Way. The models contain realistic spiral arms and a fractal distribution of clumpy dust. We fit our models to Hubble Space Telescope images corresponding to the B and I bands, using shapelet analysis and a genetic algorithm to generate 30 statistically best-fitting models. These models have a strong preference for spirality and clumpiness, with average face-on attenuation decreasing from 0.24(0.16) to 0.03(0.03) mag in the B(I) band between 0.5 and 2 radial scale-lengths. Most of the attenuation comes from small high-density clumps with low (<10%) filling factors. The fraction of dust in clumps is broadly consistent with results from fitting NGC 891's spectral energy distribution. Because of scattering effects and the intermixed nature of the dust and starlight, attenuation is smaller and less wavelength-dependent than the integrated dust column-density. Our clumpy models typically have higher attenuation at low inclinations than previous radiative transfer models using smooth distributions of stars and dust, but similar attenuation at inclinations above 70 degrees. At all inclinations most clumpy models have less attenuation than expected from previous estimates based on minimizing scatter in the Tully-Fisher relation. Mass-to-light ratios are higher and the intrinsic scatter in the Tully-Fisher relation is larger than previously expected for galaxies similar to NGC 891. The attenuation curve changes as a function of inclination, with R_(B,B-I)=A_(B)/E(B-I) increasing by ~0.75 from face-on to near-edge-on orientations.Comment: 26 pages, 18 figures, accepted for publication in Ap